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Exhibit 21
SUBSIDIARIES OF APPLIED MATERIALS, INC.
As of October 26, 2025
            
LEGAL ENTITY NAMEPLACE OF INCORPORATION
Applied Materials (Holdings)(1)California
Applied Materials Asia-Pacific, LLC(2) (3)Delaware
Applied Materials Canada, Inc.Canada
Applied Materials Holdings S.à r.l.
(4)
Luxembourg
Applied Materials India Private LimitedIndia
Applied Materials Israel Ltd.(5)Israel
Applied Ventures, LLC(6) (7)Delaware
Semitool, Inc.Montana
Tango Systems LLCDelaware
Varian Semiconductor Equipment Associates, Inc.(8)Delaware
Veranome Biosystems LLCDelaware
(1) Applied Materials (Holdings) owns the following subsidiary:
      Applied Materials UK LimitedCalifornia
(2) Applied Materials Asia-Pacific, LLC owns the following subsidiaries:
Applied Materials (China) Holdings, Ltd.(a)P.R. China
Applied Materials China, Limited(b)Hong Kong
(3) Applied Materials Asia-Pacific, LLC and Applied Materials Netherlands B.V. each partially own the following subsidiary:
Applied Materials Taiwan, Ltd.Taiwan
(4) Applied Materials Holdings S.à r.l. owns the following subsidiaries:
      Applied Materials Luxembourg 2 S.à r.l.Luxembourg
      Applied Materials U.S. Holdings LLCDelaware
(5) Applied Materials Israel Ltd. owns the following subsidiary:
      ICT Integrated Circuit Testing GmbHGermany
(6) Applied Ventures, LLC owns the following subsidiaries:
Applied Ventures Investment Management GP I, LLC(c)Delaware
Applied Ventures Investment Management GP II, LLC(d)Delaware
(7) Applied Ventures, LLC owns 50% of the following subsidiary:
Applied Ventures ITIC Innovation Fund GP, LLC(e)Delaware
    
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LEGAL ENTITY NAMEPLACE OF INCORPORATION
(8) Varian Semiconductor Equipment Associates, Inc. owns the following subsidiaries:
Applied Materials Finland International OyFinland
Applied Materials Global Venture Partner Pte. Ltd.Singapore
Applied Materials South East Asia Pte. Ltd.(c)(d)(f)Singapore
Applied Materials Straits Holdings LLCDelaware
Baccini Pte. Ltd.Singapore
Perceptive Engineering Pte. Ltd.Singapore
Picosun USA LLCMichigan
Valaya Pte. Ltd.(g)(h)Singapore
(a) Applied Materials (China) Holdings, Ltd. owns the following subsidiary:
      Applied Materials (Xi'an), Ltd.P.R. China
(b) Applied Materials China, Limited owns the following subsidiaries:
       Applied Materials (China), Inc.P.R. China
       Applied Materials Display Equipment (Shanghai) Co., Ltd.P.R. China
       Lin-gang Special Area Applied Materials (Shanghai) Co., Ltd.P.R. China
(c) Applied Ventures Investment Management GP I, LLC and Applied Materials South East Asia Pte. Ltd., collectively own 60% of the following subsidiary:
Applied Ventures Innovation Fund I, L.P.Delaware
(d) Applied Ventures Investment Management GP II, LLC and Applied Materials South East Asia Pte. Ltd., collectively own 60% of the following subsidiary:
Applied Ventures Innovation Fund II, L.P.Delaware
(e) Applied Ventures ITIC Innovation Fund GP, LLC and Applied Materials, Inc. collectively own 31.5% of the following subsidiary:
Applied Ventures ITIC Innovation Fund, L.P.Delaware
(f) Applied Materials South East Asia Pte. Ltd. owns the following subsidiaries:
Applied Materials Costa Rica Sociedad De Responsibilidad LimitadaCosta Rica
Applied Materials Europe B.V.The Netherlands
Applied Materials Holdings B.V.The Netherlands
Applied Materials Hong Kong LimitedHong Kong
Applied Materials Korea Innovation and Technology, LLCKorea
Applied Materials Netherlands B.V.(3)(j)The Netherlands
Applied Materials Philippines LLCNevada
Applied Materials Singapore Technology Pte. Ltd.Singapore
MDLSoft LLC(k)Delaware
Perceptive Engineering Limited(l)United Kingdom
Sage Design Automation, Ltd.Israel




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LEGAL ENTITY NAMEPLACE OF INCORPORATION
(g) Valaya Pte. Ltd. owns the following subsidiaries:
Valaya Enterprise LLC(h)Delaware
Valaya Innovations LLCDelaware
(h) Valaya Pte. Ltd. and Valaya Enterprise LLC each partially own the following subsidiaries:
Valaya R&D Private India LimitedIndia
(i) Applied Materials GmbH & Co. KG owns the following subsidiary:
Applied Materials WEB Coating GmbHGermany
Applied Materials Holdings GmbH(p)Germany
Applied Materials Holding LLC(p)Delaware
(j) Applied Materials Netherlands B.V. owns the following subsidiaries:
Applied Materials Belgium N.V.Belgium
Applied Materials Deutschland Holding GmbH(m)Germany
Applied Materials France S.a.r.l.France
Applied Materials Finland Holdings OyFinland
Applied Materials GmbHGermany
Applied Materials Ireland LimitedIreland
Applied Materials Italia S.r.l.Italy
Applied Materials Japan, Inc.(n)Japan
Applied Materials Korea Ltd.Korea
Impedans LimitedIreland
Picosun Oy(o)Finland
Think Silicon Single Member P.C.Greece
(k) MDLSoft LLC owns the following subsidiary:
MDLab S.r.l. in liquidationItaly
(l) Perceptive Engineering Limited owns the following subsidiaries:
Perceptive Engineering LimitedIreland
(m) Applied Materials Deutschland Holding GmbH owns the following subsidiaries:
Applied Materials GmbH & Co. KG(i)Germany
Applied Materials Verwaltung GmbHGermany
Mecatronix GmbHGermany
(n) Applied Materials Japan, Inc. owns the following subsidiaries:
Picosun Japan Co., Ltd.Japan
Sigmameltec Ltd.Japan
(o) Picosun Oy owns the following subsidiaries:
Picosun (Suzhou) Nanotechnology Co., Ltd.P.R. China
Picosun Taiwan Co. Ltd.Taiwan
(p) Applied Materials Holding LLC and Applied Materials Holdings GmbH each partially own the following subsidiary:
EMJV Holding LLCDelaware
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