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  Filed by Bristol-Myers Squibb Company
  Pursuant to Rule 425 of the Securities Act of 1933
  and deemed filed pursuant to Rule 14a-6(b)
  of the Securities Exchange Act of 1934
  Form S-4 File No.: 333-229464
  Subject Company: Celgene Corporation
  SEC File No.: 001-34912
   
    
  Explanatory Note: The following press releases were issued by
      Bristol-Myers Squibb Company on March 29, 2019.
  
  Independent Proxy Advisory Firms ISS and Glass Lewis Recommend Bristol-Myers Squibb Shareholders 
  Vote “FOR” Proposed Merger with Celgene
  
  
  Bristol-Myers Squibb Urges Shareholders to Vote “FOR” the Merger-Related Proposals on the WHITE 
  Proxy Card Today
  
  
  NEW YORK– (BUSINESS WIRE)– Bristol-Myers
      Squibb Company (NYSE:BMY) today announced that independent proxy advisory firms Institutional Shareholder Services (“ISS”) and Glass Lewis & Co. (“Glass Lewis”), recommend that Bristol-Myers Squibb shareholders vote “FOR” the approval of the
      issuance of shares of Bristol-Myers Squibb common stock in connection with the Company’s pending merger with Celgene Corporation (NASDAQ:CELG).
  
  
  In their March 29, 2019 reports, ISS and Glass Lewis stated1:
  
  
  
    
        
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             “Overall, the deal’s strategic rationale is sound. The two companies have a complementary overlap in therapeutic focus, and the
                transaction diversifies BMY’s revenue stream… The transaction also significantly enhances BMY’s pipeline, raising the number of late-stage drugs from one to six. Moreover, the combination could result in meaningful synergies – the certainty
                of which seems bolstered by the facts that the two companies have headquarters in New Jersey as well as overlapping R&D centers.” (ISS) 
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             “Celgene has a pipeline of new compounds focused on cancer and blood diseases, building off its existing strengths and complementing
                BMY’s existing drugs, which are targeted at those same areas. The acquisition should therefore strengthen BMY’s pipeline considerably.” (ISS) 
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             “Both companies’ current products and their pipelines are focused on drugs that fight cancer and blood disorders. As such, the merger
                appears logical strategically, and likely to generate more synergies than one involving disparate pharmacological areas of focus. This clinical overlap should increase synergies available to the combined company in areas such as sales and
                marketing, manufacturing, and research and development, in terms of both costs and expertise.” (ISS) 
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             “Based on our research, review and analysis, we believe the proposed merger is strategically compelling and presents the opportunity for
                potentially significant returns to shareholders of the combined company, including existing Bristol-Myers holders.” (Glass Lewis) 
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             “In particular, the merger represents an attractive, risk-adjusted opportunity to enhance Bristol-Myers’ product portfolio by leveraging
                Celgene’s current “Big Five” late-stage, near-term product launches to significantly enhance Bristol-Myers’ pipeline, thereby placing the Company in a strong position to supplement and eventually replace the revenues currently generated by
                Bristol-Myers’ existing products.” (Glass Lewis) 
           | 
        
    
     
    
  
  
  
    
  1  Permission to use quotes was neither sought nor
  obtained.   
  
  Commenting on the reports, the Company issued the following statement:
  
  
  “We are pleased that ISS and Glass Lewis share our belief that a combination with Celgene is in the best interests of the
      Company and our shareholders, and supports our Board’s recommendation that shareholders vote ‘FOR’ proposals related to the merger at the upcoming Special Meeting. We believe this transaction is the best option to continue to deliver innovative
      medicines to our patients as a means to create long-term value for our fellow shareholders.
  
  
  “Celgene’s strategic fit, compelling value proposition, and strong pipeline make this the ideal combination. The combined
      company will be stronger today, and better positioned for sustainable long-term growth, with six expected near-term product launches, strong commercialization capabilities, and a deep and broad early-stage pipeline that will position the combined
      company for sustained leadership.
  
  
  “We are confident that combining Bristol-Myers Squibb and Celgene will create a leading focused specialty biopharma company
      that is well positioned to address the needs of patients across disease areas and generate meaningful financial benefits for all shareholders through 2025 and beyond. We look forward to continuing to work with Celgene to complete the transaction, and
      strongly urge all Bristol-Myers Squibb shareholders to follow the recommendations of ISS and Glass Lewis by voting ‘FOR’ the proposals relating to the proposed transaction with Celgene at the upcoming Special Meeting.”
  
  
  Bristol-Myers Squibb and Celgene expect the transaction to close in the third quarter of 2019, subject to approval by Bristol-Myers Squibb and
      Celgene shareholders and the satisfaction of customary closing conditions and regulatory approvals. The Bristol-Myers Squibb Special Meeting of Stockholders to vote on matters relating to the proposed merger is scheduled to take place on April 12,
      2019 at 10:00 a.m. Eastern Time. All shareholders of record of Bristol-Myers Squibb common stock as of the close of business on March 1, 2019 will be entitled to vote their shares either in person or by proxy at the stockholder meeting.
  
  
  If Bristol-Myers Squibb shareholders have any questions or require assistance in voting their shares of Bristol-Myers Squibb stock, they should
      call MacKenzie Partners, Inc., Bristol-Myers Squibb’s proxy solicitor for its Special Meeting, toll-free at (800) 322-2885 or at (212) 929-5500.
  
  
  About Bristol-Myers Squibb
   
  
  Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help
      patients prevail over serious diseases. For more information about Bristol-Myers Squibb, visit us at BMS.com or follow us on LinkedIn, Twitter, YouTube and Facebook.
  
  
  
  
      
        | 
             
          If you have any questions, require assistance with voting your proxy card, 
           or need additional copies of proxy material, please contact MacKenzie Partners. 
            
            
          
            
          1407 Broadway, 27th Floor 
          New York, NY 10018 
            
          proxy@mackenziepartners.com 
            
          (212) 929-5500 or Toll-Free (800) 322-2885 
            
         | 
      
  
  
  
  Important Information for Investors and Stockholders
  
  
  
    This communication does not constitute an offer to sell or the solicitation of an offer to buy any securities or a solicitation of any vote or
        approval. It does not constitute a prospectus or prospectus equivalent document. No offering of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the U.S. Securities Act of 1933, as amended.
     
    In connection with the proposed transaction between Bristol-Myers
          Squibb Company (“Bristol-Myers Squibb”) and Celgene Corporation (“Celgene”), on February 1, 2019, Bristol-Myers Squibb filed with the Securities and Exchange Commission (the “SEC”) a registration statement on Form S-4, as amended on February 1,
          2019 and February 20, 2019, containing a joint proxy statement of Bristol-Myers Squibb and Celgene that also constitutes a prospectus of Bristol-Myers Squibb. The registration statement was declared effective by the SEC on February 22, 2019, and
          Bristol-Myers Squibb and Celgene commenced mailing the definitive joint proxy statement/prospectus to stockholders of Bristol-Myers Squibb and Celgene on or about February 22, 2019. INVESTORS AND SECURITY HOLDERS OF BRISTOL-MYERS SQUIBB AND
          CELGENE ARE URGED TO READ THE DEFINITIVE JOINT PROXY STATEMENT/PROSPECTUS AND OTHER DOCUMENTS FILED OR THAT WILL BE FILED WITH THE SEC CAREFULLY AND IN THEIR ENTIRETY BECAUSE THEY CONTAIN OR WILL CONTAIN IMPORTANT INFORMATION. Investors and
          security holders will be able to obtain free copies of the registration statement and the definitive joint proxy statement/prospectus and other documents filed with the SEC by Bristol-Myers Squibb or Celgene through the website maintained by the
          SEC at http://www.sec.gov. Copies of the documents filed with the SEC
          by Bristol-Myers Squibb are available free of charge on Bristol-Myers Squibb’s internet website at http://www.bms.com under the tab, “Investors” and under the heading “Financial Reporting” and subheading “SEC Filings” or by contacting Bristol-Myers Squibb’s Investor Relations Department through https://www.bms.com/investors/investor-contacts.html. Copies of the documents
          filed with the SEC by Celgene are available free of charge on Celgene’s internet website at http://www.celgene.com under the tab “Investors” and under the heading “Financial Information” and subheading “SEC Filings” or by contacting Celgene’s Investor Relations Department at ir@celgene.com.
   
  
  Certain Information Regarding Participants
  
  
  Bristol-Myers Squibb, Celgene, and their respective directors and executive officers may be considered participants in the solicitation of proxies
      in connection with the proposed transaction.  Information about the directors and executive officers of Bristol-Myers Squibb is set forth in its Annual Report on Form 10-K for the year ended December 31, 2018, which was filed with the SEC on February
      25, 2019, its proxy statement for its 2018 annual meeting of stockholders, which was filed with the SEC on March 22, 2018, and its Current Report on Form 8-K, which was filed with the SEC on August 28, 2018. Information about the directors and
      executive officers of Celgene is set forth in its Annual Report on Form 10-K for the year ended December 31, 2018, which was filed with the SEC on February 26, 2019, as amended on March 1, 2019. Other information regarding the participants in the
      proxy solicitations and a description of their direct and indirect interests, by security holdings or otherwise, are contained in the definitive joint proxy statement/prospectus of Bristol-Myers Squibb and Celgene filed with the SEC and other
      relevant materials to be filed with the SEC regarding the proposed transaction when they become available. You may obtain these documents (when they become available) free of charge through the website maintained by the SEC at http://www.sec.gov and
      from Investor Relations at Bristol-Myers Squibb or Celgene as described above.
    
  Cautionary Statement Regarding Forward-Looking Statements
   
  This communication contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section
      21E of the Securities Exchange Act of 1934, as amended.  You can generally identify forward-looking statements by the use of forward-looking terminology such as “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “explore,”
      “evaluate,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “seek,” “should,” or “will,” or the negative thereof or other variations thereon or comparable terminology.  These forward-looking statements are only predictions and
      involve known and unknown risks and uncertainties, many of which are beyond Bristol-Myers Squibb’s and Celgene’s control.
   
  Statements in this communication regarding Bristol-Myers Squibb, Celgene and the combined company that are forward-looking, including projections
      as to the anticipated benefits of the proposed transaction, the impact of the proposed transaction on Bristol-Myers Squibb’s and Celgene’s business and future financial and operating results, the amount and timing of synergies from the proposed
      transaction, the terms and scope of the expected financing for the proposed transaction, the aggregate amount of indebtedness of the combined company following the closing of the proposed transaction, expectations regarding cash flow generation,
      accretion to cash earnings per share, capital structure, debt repayment, and credit ratings following the closing of the proposed transaction, Bristol-Myers Squibb’s ability and intent to conduct a share repurchase program and declare future dividend
      payments, the combined company’s pipeline, intellectual property protection and R&D spend, the timing and probability of a payment pursuant to the contingent value right consideration, and the closing date for the proposed transaction, are based
      on management’s estimates, assumptions and projections, and are subject to significant uncertainties and other factors, many of which are beyond Bristol-Myers Squibb’s and Celgene’s control. These factors include, among other things, effects of the
      continuing implementation of governmental laws and regulations related to Medicare, Medicaid, Medicaid managed care organizations and entities under the Public Health Service 340B program, pharmaceutical rebates and reimbursement, market factors,
      competitive product development and approvals, pricing controls and pressures (including changes in rules and practices of managed care groups and institutional and governmental purchasers), economic conditions such as interest rate and currency
      exchange rate fluctuations, judicial decisions, claims and concerns that may arise regarding the safety and efficacy of in-line products and product candidates, changes to wholesaler inventory levels, variability in data provided by third parties,
      changes in, and interpretation of, governmental regulations and legislation affecting domestic or foreign operations, including tax obligations, changes to business or tax planning strategies, difficulties and delays in product development,
      manufacturing or sales including any potential future recalls, patent positions and the ultimate outcome of any litigation matter. These factors also include the combined company’s ability to execute successfully its strategic plans, including its
      business development strategy, the expiration of patents or data protection on certain products, including assumptions about the combined company’s ability to retain patent exclusivity of certain products, the impact and result of governmental
      investigations, the combined company’s ability to obtain necessary regulatory approvals or obtaining these without delay, the risk that the combined company’s products prove to be commercially successful or that contractual milestones will be
      achieved. Similarly, there are uncertainties relating to a number of other important factors, including: results of clinical trials and preclinical studies, including subsequent analysis of existing data and new data received from ongoing and future
      studies; the content and timing of decisions made by the U.S. FDA and other regulatory authorities, investigational review boards at clinical trial sites and publication review bodies; the ability to enroll patients in planned clinical trials;
      unplanned cash requirements and expenditures; competitive factors; the ability to obtain, maintain and enforce patent and other intellectual property protection for any product candidates; the ability to maintain key collaborations; and general
      economic and market conditions. Additional information concerning these risks, uncertainties and assumptions can be found in Bristol-Myers Squibb’s and Celgene’s respective filings with the SEC, including the risk factors discussed in Bristol-Myers
      Squibb’s and Celgene’s most recent Annual Reports on Form 10-K, as updated by their Quarterly Reports on Form 10-Q and future filings with the SEC.
  
  It should also be noted that projected financial information for the combined businesses of Bristol-Myers Squibb and Celgene is based on
      management’s estimates, assumptions and projections and has not been prepared in conformance with the applicable accounting requirements of Regulation S-X relating to pro forma financial information, and the required pro forma adjustments have not
      been applied and are not reflected therein. None of this information should be considered in isolation from, or as a substitute for, the historical financial statements of Bristol-Myers Squibb or Celgene. Important risk factors could cause actual
      future results and other future events to differ materially from those currently estimated by management, including, but not limited to, the risks that: a condition to the closing of the proposed acquisition may not be satisfied; a regulatory
      approval that may be required for the proposed acquisition is delayed, is not obtained or is obtained subject to conditions that are not anticipated; Bristol-Myers Squibb is unable to achieve the synergies and value creation contemplated by the
      proposed acquisition; Bristol-Myers Squibb is unable to promptly and effectively integrate Celgene’s businesses; management’s time and attention is diverted on transaction related issues; disruption from the transaction makes it more difficult to
      maintain business, contractual and operational relationships; the credit ratings of the combined company decline following the proposed acquisition; legal proceedings are instituted against Bristol-Myers Squibb, Celgene or the combined company;
      Bristol-Myers Squibb, Celgene or the combined company is unable to retain key personnel; and the announcement or the consummation of the proposed acquisition has a negative effect on the market price of the capital stock of Bristol-Myers Squibb and
      Celgene or on Bristol-Myers Squibb’s and Celgene’s operating results.
  
  
  No assurances can be given that any of the events anticipated by the forward-looking statements will transpire or occur, or if any of them do
      occur, what impact they will have on the results of operations, financial condition or cash flows of Bristol-Myers Squibb or Celgene. Should any risks and uncertainties develop into actual events, these developments could have a material adverse
      effect on the proposed transaction and/or Bristol-Myers Squibb or Celgene, Bristol-Myers Squibb’s ability to successfully complete the proposed transaction and/or realize the expected benefits from the proposed transaction.
  
  
  You are cautioned not to rely on Bristol-Myers Squibb’s and Celgene’s forward-looking statements. These forward-looking statements are and will be
      based upon management’s then-current views and assumptions regarding future events and operating performance, and are applicable only as of the dates of such statements. You also should understand that it is not possible to predict or identify all
      such factors and that this list should not be considered a complete statement of all potential risks and uncertainties. Investors also should realize that if underlying assumptions prove inaccurate or if unknown risks or uncertainties materialize,
      actual results could vary materially from Bristol-Myers Squibb’s or Celgene’s projections. Except as otherwise required by law, neither Bristol-Myers Squibb nor Celgene is under any obligation, and each expressly disclaim any obligation, to update,
      alter, or otherwise revise any forward-looking statements included in this communication or elsewhere, whether written or oral, that may be made from time to time relating to any of the matters discussed in this communication, whether as a result of
      new information, future events or otherwise, as of any future date.
  
  
  Contacts
  
  
  Media:
  Carrie Fernandez
  609-252-5222
  carrie.fernandez@bms.com
  
  
  or
  
  
  Andy Brimmer / Dan Katcher
  Joele Frank, Wilkinson Brimmer Katcher
  212-355-4449
  
  
  Investors:
  Tim Power
  609-252-7509
  timothy.power@bms.com
  
  
  or
  
  
  Dan Burch
  MacKenzie Partners, Inc.
  212-929-5748
  dburch@mackenziepartners.com
  
  
    Bristol-Myers Squibb Issues Statement on Celgene’s Settlement
    with Alvogen on Revlimid® Patent Litigation
    
    
    NEW YORK–(BUSINESS WIRE)– Bristol-Myers
        Squibb Company (NYSE:BMY) today issued the following statement regarding Celgene’s (NASDAQ:CELG) settlement with Lotus Pharmaceutical Co., Ltd. and Alvogen Pine Brook, LLC (collectively, “Alvogen”) relating to patents for Revlimid:
    
    
    “We are pleased that Celgene has reached a settlement with Alvogen related to patents for Revlimid. This announcement is
        consistent with our assumptions during due diligence and provides further clarity and security around the patent estate for Revlimid. We are confident in the strength of our combination with Celgene and our ability to create a premier biopharma
        company with leading franchises and a deep and broad pipeline that will drive sustainable growth.
    
    
    We look forward to continuing to work with Celgene to complete the transaction, and strongly urge all Bristol-Myers Squibb
        shareholders to vote ‘FOR’ the proposals relating to the proposed transaction with Celgene at the upcoming Special Meeting.”
    
    
    Additionally, the Company noted that in a March 29, 2019 report published prior to the disclosure of the settlement, Institutional Shareholder
        Services, an independent proxy advisory firm, concluded1:
    
    
    “BMY’s perspective [about Revlimid] appears to be shared by a majority of the analyst community, and it has been strengthened
        since announcement of the deal by intervening events such as the PTAB’s recent IPR rulings in favor of Celgene.”
    
    
    Bristol-Myers Squibb and Celgene expect the transaction to close in the third quarter of 2019, subject to approval by Bristol-Myers Squibb and
        Celgene shareholders and the satisfaction of customary closing conditions and regulatory approvals. The Bristol-Myers Squibb Special Meeting of Stockholders to vote on matters relating to the proposed merger is scheduled to take place on April 12,
        2019 at 10:00 a.m. Eastern Time. All shareholders of record of Bristol-Myers Squibb common stock as of the close of business on March 1, 2019 will be entitled to vote their shares either in person or by proxy at the stockholder meeting.
    
    
    If Bristol-Myers Squibb shareholders have any questions or require assistance in voting their shares of Bristol-Myers Squibb stock, they should
        call MacKenzie Partners, Inc., Bristol-Myers Squibb’s proxy solicitor for its Special Meeting, toll-free at (800) 322-2885 or at (212) 929-5500.
    
    
    About Bristol-Myers Squibb
     
    
    Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help
        patients prevail over serious diseases. For more information about Bristol-Myers Squibb, visit us at BMS.com or follow us on LinkedIn, Twitter, YouTube and Facebook.
    
    
    
      
        
      1  Permission to use quotes was neither sought nor
      obtained. 
 
    
    
        
          | 
               
            If you have any questions, require assistance with voting your proxy card, 
             or need additional copies of proxy material, please contact MacKenzie Partners. 
              
              
            
              
            1407 Broadway, 27th Floor 
            New York, NY 10018 
              
            proxy@mackenziepartners.com 
              
            (212) 929-5500 or Toll-Free (800) 322-2885 
              
           | 
        
    
    
    
    Important Information for Investors and Stockholders
    
    
    
      This communication does not constitute an offer to sell or the solicitation of an offer to buy any securities or a solicitation of any vote or
          approval. It does not constitute a prospectus or prospectus equivalent document. No offering of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the U.S. Securities Act of 1933, as amended.
       
      In connection with the proposed transaction between Bristol-Myers
            Squibb Company (“Bristol-Myers Squibb”) and Celgene Corporation (“Celgene”), on February 1, 2019, Bristol-Myers Squibb filed with the Securities and Exchange Commission (the “SEC”) a registration statement on Form S-4, as amended on February 1,
            2019 and February 20, 2019, containing a joint proxy statement of Bristol-Myers Squibb and Celgene that also constitutes a prospectus of Bristol-Myers Squibb. The registration statement was declared effective by the SEC on February 22, 2019,
            and Bristol-Myers Squibb and Celgene commenced mailing the definitive joint proxy statement/prospectus to stockholders of Bristol-Myers Squibb and Celgene on or about February 22, 2019. INVESTORS AND SECURITY HOLDERS OF BRISTOL-MYERS SQUIBB AND
            CELGENE ARE URGED TO READ THE DEFINITIVE JOINT PROXY STATEMENT/PROSPECTUS AND OTHER DOCUMENTS FILED OR THAT WILL BE FILED WITH THE SEC CAREFULLY AND IN THEIR ENTIRETY BECAUSE THEY CONTAIN OR WILL CONTAIN IMPORTANT INFORMATION. Investors and
            security holders will be able to obtain free copies of the registration statement and the definitive joint proxy statement/prospectus and other documents filed with the SEC by Bristol-Myers Squibb or Celgene through the website maintained by
            the SEC at http://www.sec.gov. Copies of the documents filed with
            the SEC by Bristol-Myers Squibb are available free of charge on Bristol-Myers Squibb’s internet website at http://www.bms.com under the tab, “Investors” and under the heading “Financial Reporting” and subheading “SEC Filings” or by contacting Bristol-Myers Squibb’s Investor Relations Department
            through https://www.bms.com/investors/investor-contacts.html. Copies
            of the documents filed with the SEC by Celgene are available free of charge on Celgene’s internet website at http://www.celgene.com under the tab “Investors” and under the heading “Financial Information” and subheading “SEC Filings” or by contacting Celgene’s Investor Relations Department at ir@celgene.com.
     
    
    Certain Information Regarding Participants
    
    
    Bristol-Myers Squibb, Celgene, and their respective directors and executive officers may be considered participants in the solicitation of
        proxies in connection with the proposed transaction.  Information about the directors and executive officers of Bristol-Myers Squibb is set forth in its Annual Report on Form 10-K for the year ended December 31, 2018, which was filed with the SEC
        on February 25, 2019, its proxy statement for its 2018 annual meeting of stockholders, which was filed with the SEC on March 22, 2018, and its Current Report on Form 8-K, which was filed with the SEC on August 28, 2018.  Information about the
        directors and executive officers of Celgene is set forth in its Annual Report on Form 10-K for the year ended December 31, 2018, which was filed with the SEC on February 26, 2019, as amended on March 1, 2019. Other information regarding the
        participants in the proxy solicitations and a description of their direct and indirect interests, by security holdings or otherwise, are contained in the definitive joint proxy statement/prospectus of Bristol-Myers Squibb and Celgene filed with the
        SEC and other relevant materials to be filed with the SEC regarding the proposed transaction when they become available. You may obtain these documents (when they become available) free of charge through the website maintained by the SEC at
        http://www.sec.gov and from Investor Relations at Bristol-Myers Squibb or Celgene as described above.
      
    Cautionary Statement Regarding Forward-Looking Statements
     
    This communication contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section
        21E of the Securities Exchange Act of 1934, as amended.  You can generally identify forward-looking statements by the use of forward-looking terminology such as “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “explore,”
        “evaluate,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “seek,” “should,” or “will,” or the negative thereof or other variations thereon or comparable terminology.  These forward-looking statements are only predictions and
        involve known and unknown risks and uncertainties, many of which are beyond Bristol-Myers Squibb’s and Celgene’s control.
     
    Statements in this communication regarding Bristol-Myers Squibb, Celgene and the combined company that are forward-looking, including
        projections as to the anticipated benefits of the proposed transaction, the impact of the proposed transaction on Bristol-Myers Squibb’s and Celgene’s business and future financial and operating results, the amount and timing of synergies from the
        proposed transaction, the terms and scope of the expected financing for the proposed transaction, the aggregate amount of indebtedness of the combined company following the closing of the proposed transaction, expectations regarding cash flow
        generation, accretion to cash earnings per share, capital structure, debt repayment, and credit ratings following the closing of the proposed transaction, Bristol-Myers Squibb’s ability and intent to conduct a share repurchase program and declare
        future dividend payments, the combined company’s pipeline, intellectual property protection and R&D spend, the timing and probability of a payment pursuant to the contingent value right consideration, and the closing date for the proposed
        transaction, are based on management’s estimates, assumptions and projections, and are subject to significant uncertainties and other factors, many of which are beyond Bristol-Myers Squibb’s and Celgene’s control. These factors include, among other
        things, effects of the continuing implementation of governmental laws and regulations related to Medicare, Medicaid, Medicaid managed care organizations and entities under the Public Health Service 340B program, pharmaceutical rebates and
        reimbursement, market factors, competitive product development and approvals, pricing controls and pressures (including changes in rules and practices of managed care groups and institutional and governmental purchasers), economic conditions such
        as interest rate and currency exchange rate fluctuations, judicial decisions, claims and concerns that may arise regarding the safety and efficacy of in-line products and product candidates, changes to wholesaler inventory levels, variability in
        data provided by third parties, changes in, and interpretation of, governmental regulations and legislation affecting domestic or foreign operations, including tax obligations, changes to business or tax planning strategies, difficulties and delays
        in product development, manufacturing or sales including any potential future recalls, patent positions and the ultimate outcome of any litigation matter. These factors also include the combined company’s ability to execute successfully its
        strategic plans, including its business development strategy, the expiration of patents or data protection on certain products, including assumptions about the combined company’s ability to retain patent exclusivity of certain products, the impact
        and result of governmental investigations, the combined company’s ability to obtain necessary regulatory approvals or obtaining these without delay, the risk that the combined company’s products prove to be commercially successful or that
        contractual milestones will be achieved. Similarly, there are uncertainties relating to a number of other important factors, including: results of clinical trials and preclinical studies, including subsequent analysis of existing data and new data
        received from ongoing and future studies; the content and timing of decisions made by the U.S. FDA and other regulatory authorities, investigational review boards at clinical trial sites and publication review bodies; the ability to enroll patients
        in planned clinical trials; unplanned cash requirements and expenditures; competitive factors; the ability to obtain, maintain and enforce patent and other intellectual property protection for any product candidates; the ability to maintain key
        collaborations; and general economic and market conditions. Additional information concerning these risks, uncertainties and assumptions can be found in Bristol-Myers Squibb’s and Celgene’s respective filings with the SEC, including the risk
        factors discussed in Bristol-Myers Squibb’s and Celgene’s most recent Annual Reports on Form 10-K, as updated by their Quarterly Reports on Form 10-Q and future filings with the SEC.
    
    It should also be noted that projected financial information for the combined businesses of Bristol-Myers Squibb and Celgene is based on
        management’s estimates, assumptions and projections and has not been prepared in conformance with the applicable accounting requirements of Regulation S-X relating to pro forma financial information, and the required pro forma adjustments have not
        been applied and are not reflected therein. None of this information should be considered in isolation from, or as a substitute for, the historical financial statements of Bristol-Myers Squibb or Celgene. Important risk factors could cause actual
        future results and other future events to differ materially from those currently estimated by management, including, but not limited to, the risks that: a condition to the closing of the proposed acquisition may not be satisfied; a regulatory
        approval that may be required for the proposed acquisition is delayed, is not obtained or is obtained subject to conditions that are not anticipated; Bristol-Myers Squibb is unable to achieve the synergies and value creation contemplated by the
        proposed acquisition; Bristol-Myers Squibb is unable to promptly and effectively integrate Celgene’s businesses; management’s time and attention is diverted on transaction related issues; disruption from the transaction makes it more difficult to
        maintain business, contractual and operational relationships; the credit ratings of the combined company decline following the proposed acquisition; legal proceedings are instituted against Bristol-Myers Squibb, Celgene or the combined company;
        Bristol-Myers Squibb, Celgene or the combined company is unable to retain key personnel; and the announcement or the consummation of the proposed acquisition has a negative effect on the market price of the capital stock of Bristol-Myers Squibb and
        Celgene or on Bristol-Myers Squibb’s and Celgene’s operating results.
    
    
    No assurances can be given that any of the events anticipated by the forward-looking statements will transpire or occur, or if any of them do
        occur, what impact they will have on the results of operations, financial condition or cash flows of Bristol-Myers Squibb or Celgene. Should any risks and uncertainties develop into actual events, these developments could have a material adverse
        effect on the proposed transaction and/or Bristol-Myers Squibb or Celgene, Bristol-Myers Squibb’s ability to successfully complete the proposed transaction and/or realize the expected benefits from the proposed transaction.
    
    
    You are cautioned not to rely on Bristol-Myers Squibb’s and Celgene’s forward-looking statements. These forward-looking statements are and will
        be based upon management’s then-current views and assumptions regarding future events and operating performance, and are applicable only as of the dates of such statements. You also should understand that it is not possible to predict or identify
        all such factors and that this list should not be considered a complete statement of all potential risks and uncertainties. Investors also should realize that if underlying assumptions prove inaccurate or if unknown risks or uncertainties
        materialize, actual results could vary materially from Bristol-Myers Squibb’s or Celgene’s projections. Except as otherwise required by law, neither Bristol-Myers Squibb nor Celgene is under any obligation, and each expressly disclaim any
        obligation, to update, alter, or otherwise revise any forward-looking statements included in this communication or elsewhere, whether written or oral, that may be made from time to time relating to any of the matters discussed in this
        communication, whether as a result of new information, future events or otherwise, as of any future date.
    
    
    Contacts
    
    
    Media:
    Carrie Fernandez
    609-252-5222
    carrie.fernandez@bms.com
    
    
    or
    
    
    Andy Brimmer / Dan Katcher
    Joele Frank, Wilkinson Brimmer Katcher
    212-355-4449
    
    
    Investors:
    Tim Power
    609-252-7509
    timothy.power@bms.com
    
    
    or
    
    
    Dan Burch
    MacKenzie Partners, Inc.
    212-929-5748
    dburch@mackenziepartners.com