EX-FILING FEES

Exhibit 107

Calculation of Filing Fee Tables

(1)

424(b)(2)

(Form Type)

Eli Lilly and Company

(Exact Name of Registrant as Specified in its

Charter)

Table 1: Newly Registered and Carry Forward Securities

Security
Type

Security
Class

Title

Fee
Calculation
or Carry
Forward
Rule

Amount

Registered

Proposed
Maximum
Offering
Price Per
Unit

Maximum

Aggregate

Offering

Price

Fee

Rate

Amount of
Registration

Fee

Carry
Forward
Form
Type

Carry
Forward
File
Number

Carry
Forward
Initial
effective
date

Filing Fee
Previously
Paid In
Connection
with
Unsold
Securities
to be
Carried
Forward

Newly Registered Securities

Fees to Be

Paid

Debt

4.550%

notes due 2028

Rule 457(r)

$1,000,000,000

99.936%

$999,360,000

0.00015310

$153,002.02

Debt

4.750%

notes due 2030

Rule 457(r)

$1,250,000,000

99.943%

$1,249,287,500

0.00015310

$191,265.92

Debt

4.900%

notes due 2032

Rule 457(r)

$1,000,000,000

99.853%

$998,530,000

0.00015310

$152,874.94

Debt

5.100%

notes due 2035

Rule 457(r)

$1,250,000,000

99.977%

$1,249,712,500

0.00015310

$191,330.98

Debt

5.500%

notes due 2055

Rule 457(r)

$1,250,000,000

99.781%

$1,247,262,500

0.00015310

$190,955.89

Debt

5.600%

notes due 2065

Rule 457(r)

$750,000,000

99.762%

$748,215,000

0.00015310

$114,551.72

Fees

Previously

Paid

N/A

Carry Forward Securities

Carry

Forward Securities

N/A

Total Offering Amounts

$6,492,367,500.00

$993,981.46

Total Fees Previously Paid

N/A

Total Fee Offsets

N/A

Net Fee Due

$993,981.46

(1)

These “Calculation of Filing Fee Tables” shall be deemed to update the “Calculation of Filing Fee Tables” in Eli Lilly and Company’s Registration Statement on Form

S-3

(File

No. 333-262943),

which was filed on February 24, 2022, in accordance with Rules 456(b) and 457(r) under the Securities Act of 1933, as amended. The prospectus supplement to which this exhibit is attached is a final prospectus for the related offering.