 
        Margaret M. Madden  Pfizer Inc.  66 Hudson Boulevard East  New York, NY 10001      YOUR VOTE IS IMPORTANT - PLEASE VOTE YOUR SHARES TODAY      Dear Fellow Pfizer Shareholder:    On April 24, 2025, Pfizer will hold its Annual Meeting of Shareholders. We value your input as a holder of  Pfizer common stock and encourage you to review our proxy materials and cast your vote today. You can  view our proxy materials at https://investors.pfizer.com/proxy.    For the reasons set forth in the 2025 Proxy Statement, the Board of Directors recommends that you vote:     “FOR” each Director nominee.    “FOR” the ratification of the selection of KPMG LLP as Pfizer’s independent registered public  accounting firm for 2025.   ‘’FOR” the 2025 advisory approval of executive compensation.   “AGAINST” the two shareholder proposals.     The 2025 Annual Meeting will be held virtually. Please view our 2025 Proxy Statement for details on how  you can participate.    I encourage you to vote in advance of the Annual Meeting by using one of the methods described in the  proxy materials. For your convenience, a duplicate proxy/voting instruction card and return envelope are  enclosed, along with telephone and Internet voting instructions. Please note, if multiple proxies/voting  instruction cards are received from you, the one with the latest date will be counted.     Your vote is important. Ensure your shares are voted by acting today.     Sincerely,          Margaret M. Madden  Senior Vice President and Corporate Secretary, Chief Governance Counsel