| Security Type | Security Class Title | Fee Calculation Rule | Amount Registered (2) | Proposed Maximum Offering Price Per Unit | Maximum Aggregate Offering Price | Fee Rate | Amount of Registration Fee | |||||||||
| Newly Registered Securities | ||||||||||||||||
| Paid  | $ | $ | $ | |||||||||||||
| $ | $ | $ | ||||||||||||||
| $ | $ | $ | ||||||||||||||
| $ | $ | $ | ||||||||||||||
| N/A | N/A | N/A | N/A | (3) | ||||||||||||
| Total | $ 3,700,290,000.00 | $ | $ | |||||||||||||
| (1) | The prospectus supplement to which this Exhibit is attached is a  | 
| (2) | The amount registered, maximum aggregate offering price and registration fee have been calculated by converting the amount registered from Euros to U.S. Dollars based upon the Euro to U.S. Dollar exchange rate as of 9 a.m. (London time) on May 14, 2025 on the Bloomberg page “BFIX” of €1.00/$1.12130.  | 
| (3) | Pfizer Inc. will fully and unconditionally guarantee the notes issued by Pfizer Netherlands International Finance B.V. Pursuant to Rule 457(n) under the Securities Act of 1933, as amended, no separate filing fee is required for the guarantees.  |