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               Issuer: 
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               Thermo Fisher Scientific Inc. 
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               Securities: 
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               4.200% Senior Notes due 2031 
              4.473% Senior Notes due 2032 
              4.794% Senior Notes due 2035 
              4.894% Senior Notes due 2037 
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               Aggregate Principal Amount: 
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               2031 Notes: $500,000,000 
              2032 Notes: $750,000,000 
              2035 Notes: $750,000,000 
              2037 Notes: $500,000,000 
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               Stated Maturity Date: 
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               2031 Notes: March 1, 2031 
              2032 Notes: October 7, 2032 
              2035 Notes: October 7, 2035 
              2037 Notes: October 7, 2037 
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               Issue Price: 
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               2031 Notes: 99.874% of the principal amount 
              2032 Notes: 100.000% of the principal amount 
              2035 Notes: 100.000% of the principal amount 
              2037 Notes: 100.000% of the principal amount 
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               Coupon (Interest Rate): 
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               2031 Notes: 4.200% per annum 
              2032 Notes: 4.473% per annum 
              2035 Notes: 4.794% per annum 
              2037 Notes: 4.894% per annum 
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               Yield to Maturity: 
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               2031 Notes: 4.227% 
              2032 Notes: 4.473% 
              2035 Notes: 4.794% 
              2037 Notes: 4.894% 
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               Benchmark Treasury: 
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               2031 Notes: UST 3.625% due September 30, 2030 
              2032 Notes: UST 3.875% due September 30, 2032 
              2035 Notes: UST 4.250% due August 15, 2035 
              2037 Notes: UST 4.250% due August 15, 2035 
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               Benchmark Treasury Price and Yield: 
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               2031 Notes: 99-17 ¼ / 3.727% 
              2032 Notes: 99-22 ¾ / 3.923% 
              2035 Notes: 100-27 / 4.144% 
              2037 Notes: 100-27 / 4.144% 
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               Spread to Benchmark Treasury Yield: 
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               2031 Notes: 50 basis points 
              2032 Notes: 55 basis points 
              2035 Notes: 65 basis points 
              2037 Notes: 75 basis points 
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               Interest Payment Dates: 
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               2031 Notes: March 1 and September 1 of each year, beginning on March 1, 2026 
              2032 Notes: April 7 and October 7 of each year, beginning on April 7, 2026 
              2035 Notes: April 7 and October 7 of each year, beginning on April 7, 2026 
              2037 Notes: April 7 and October 7 of each year, beginning on April 7, 2026 
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               Make-Whole Call: 
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               2031 Notes: 10 basis points (prior to February 1, 2031) 
              2032 Notes: 10 basis points (prior to August 7, 2032) 
              2035 Notes: 10 basis points (prior to July 7, 2035) 
              2037 Notes: 15 basis points (prior to July 7, 2037) 
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               Par Call: 
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               2031 Notes: On or after February 1, 2031 
              2032 Notes: On or after August 7, 2032 
              2035 Notes: On or after July 7, 2035 
              2037 Notes: On or after July 7, 2037 
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               CUSIP / ISIN: 
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               2031 Notes: 883556DC3 / US883556DC34 
              2032 Notes: 883556DD1 / US883556DD17 
              2035 Notes: 883556DE9 / US883556DE99 
              2037 Notes: 883556DF6 / US883556DF64 
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               Trade Date: 
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               September 30, 2025 
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               Settlement Date: 
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               October 7, 2025 (T+5); under Rule 15c6-1 under the Securities Exchange Act of 1934,
                  trades in the secondary market generally are required to settle in one business day, unless the parties to that trade expressly agree otherwise. Accordingly, purchasers who wish to trade the notes before the first business day prior to
                  the Settlement Date will be required, by virtue of the fact that the notes initially will settle on a delayed basis, to specify an alternate settlement cycle at the time of any such trade to prevent a failed settlement and should consult
                  their own advisors with respect to these matters. 
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               Trustee: 
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               The Bank of New York Mellon Trust Company, N.A. 
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               Joint Book-Running Managers: 
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               J.P. Morgan Securities LLC 
              ING Financial Markets LLC 
              Mizuho Securities USA LLC 
              Scotia Capital (USA) Inc. 
              Barclays Capital Inc. 
              HSBC Securities (USA) Inc. 
              Morgan Stanley & Co. LLC 
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               Co-Managers: 
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               BNP Paribas Securities Corp. 
              BNY Mellon Capital Markets, LLC 
              BofA Securities, Inc. 
              Citigroup Global Markets Inc. 
              Deutsche Bank Securities Inc. 
              Drexel Hamilton, LLC 
              Goldman Sachs & Co. LLC 
              KeyBanc Capital Markets Inc. 
              Loop Capital Markets LLC 
              MUFG Securities Americas Inc. 
              Nordea Bank Abp 
              R. Seelaus & Co., LLC 
              RBC Capital Markets, LLC 
              SMBC Nikko Securities America, Inc. 
              U.S. Bancorp Investments, Inc. 
              UBS Securities LLC 
              Wells Fargo Securities, LLC 
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