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S-3 424B5 EX-FILING FEES 333-278066 0000310158 Merck & Co., Inc. N/A N/A 0000310158 2025-09-04 2025-09-04 0000310158 1 2025-09-04 2025-09-04 0000310158 2 2025-09-04 2025-09-04 0000310158 3 2025-09-04 2025-09-04 0000310158 4 2025-09-04 2025-09-04 0000310158 5 2025-09-04 2025-09-04 0000310158 6 2025-09-04 2025-09-04 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables

S-3

Merck & Co., Inc.

Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Carry Forward Form Type

Carry Forward File Number

Carry Forward Initial Effective Date

Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward

Newly Registered Securities
Fees to be Paid 1 Debt Floating Rate Notes due 2027 457(r) 500,000,000 $ 500,000,000.00 0.0001531 $ 76,550.00
Fees to be Paid 2 Debt 3.850% Notes due 2027 457(r) 750,000,000 $ 749,287,500.00 0.0001531 $ 114,715.92
Fees to be Paid 3 Debt 4.150% Notes due 2030 457(r) 750,000,000 $ 748,747,500.00 0.0001531 $ 114,633.24
Fees to be Paid 4 Debt 4.550% Notes due 2032 457(r) 1,000,000,000 $ 999,810,000.00 0.0001531 $ 153,070.91
Fees to be Paid 5 Debt 4.950% Notes due 2035 457(r) 1,750,000,000 $ 1,749,842,500.00 0.0001531 $ 267,900.89
Fees to be Paid 6 Debt 5.700% Notes due 2055 457(r) 1,250,000,000 $ 1,246,237,500.00 0.0001531 $ 190,798.96
Fees Previously Paid
Carry Forward Securities
Carry Forward Securities

Total Offering Amounts:

$ 5,993,925,000.00

$ 917,669.92

Total Fees Previously Paid:

$ 0.00

Total Fee Offsets:

$ 0.00

Net Fee Due:

$ 917,669.92

Offering Note

1

This registration fee table shall be deemed to update the "Calculation of Filing Fee Tables" in the registrant's Registration Statement on Form S-3ASR (Registration No. 333-278066), originally filed with the Securities and Exchange Commission (the "Commission") on March 19, 2024 and subsequently amended by Post-Effective Amendment No. 1 filed with the Commission on May 14, 2024, in accordance with Rules 456(b) and 457(r) under the Securities Act of 1933, as amended.

2

See note 1.

3

See note 1.

4

See note 1.

5

See note 1.

6

See note 1.
Table 2: Fee Offset Claims and Sources ☑Not Applicable
Registrant or Filer Name Form or Filing Type File Number Initial Filing Date Filing Date Fee Offset Claimed Security Type Associated with Fee Offset Claimed Security Title Associated with Fee Offset Claimed Unsold Securities Associated with Fee Offset Claimed Unsold Aggregate Offering Amount Associated with Fee Offset Claimed Fee Paid with Fee Offset Source
Rules 457(b) and 0-11(a)(2)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Rule 457(p)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Table 3: Combined Prospectuses ☑Not Applicable

Security Type

Security Class Title

Amount of Securities Previously Registered

Maximum Aggregate Offering Price of Securities Previously Registered

Form Type

File Number

Initial Effective Date

N/A N/A N/A N/A N/A N/A N/A N/A
Narrative Disclosure
The maximum aggregate offering price of the securities to which the prospectus relates is $5,993,925,000.00. The prospectus is a final prospectus for the related offering.