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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington D.C. 20549

FORM 11-K

(Mark One)


			ý			ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2024


			¨			TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

Commission file number 001-37702

RETIREMENT AND SAVINGS PLAN FOR

AMGEN MANUFACTURING LIMITED LLC

State Road 31, Kilometer 24.6, Juncos, Puerto Rico 00777

(Full title and address of the plan)

AMGEN INC.

(Name of issuer of the securities held)



One Amgen Center Drive,						91320-1799
Thousand Oaks, California						(Zip Code)
(Address of principal executive offices)

Retirement and Savings Plan for

Amgen Manufacturing Limited LLC

Audited Financial Statements

and Supplemental Schedule

Year Ended December 31, 2024

Contents



Report of Independent Registered Public Accounting Firm			1

Audited Financial Statements:

Statements of Net Assets Available for Benefits at December 31, 2024 and 2023			2
Statement of Changes in Net Assets Available for Benefits for the year ended December 31, 2024			3
Notes to Financial Statements			4

Supplemental Schedule:

Schedule of Assets (Held at End of Year)			10

Index to Exhibit			18
Signatures			19

Report of Independent Registered Public Accounting Firm

To the Plan Participants and the Plan Administrator of the Retirement and Savings Plan for Amgen Manufacturing Limited LLC

Opinion on the Financial Statements

We have audited the accompanying statements of net assets available for benefits of the Retirement and Savings Plan for Amgen Manufacturing Limited LLC (the Plan) as of December 31, 2024 and 2023, and the related statement of changes in net assets available for benefits for the year ended December 31, 2024, and the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the net assets available for benefits of the Plan at December 31, 2024 and 2023, and the changes in its net assets available for benefits for the year ended December 31, 2024, in conformity with U.S. generally accepted accounting principles.

Basis for Opinion

These financial statements are the responsibility of the Plan’s management. Our responsibility is to express an opinion on the Plan’s financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Plan in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Plan is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Plan’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

Supplemental Schedule Required by ERISA

The accompanying supplemental schedule of assets (held at end of year) as of December 31, 2024, (referred to as the “supplemental schedule”), has been subjected to audit procedures performed in conjunction with the audit of the Plan’s financial statements. The information in the supplemental schedule is the responsibility of the Plan’s management. Our audit procedures included determining whether the information reconciles to the financial statements or the underlying accounting and other records, as applicable, and performing procedures to test the completeness and accuracy of the information presented in the supplemental schedule. In forming our opinion on the information, we evaluated whether such information, including its form and content, is presented in conformity with the Department of Labor’s Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income Security Act of 1974. In our opinion, the information is fairly stated, in all material respects, in relation to the financial statements as a whole.

/s/ ERNST & YOUNG LLP

We have served as the Plan’s auditor since 1992.

Los Angeles, California

June 12, 2025

Retirement and Savings Plan for Amgen Manufacturing Limited LLC

Statements of Net Assets Available for Benefits


	December 31,
	2024		2023
Assets
Investments at fair value	$	762,010,202	$	702,634,440
Notes receivable from participants	18,107,898		16,846,516
Other – principally due from broker	302,276		713,083
Total assets	780,420,376		720,194,039
Liabilities
Other – principally due to broker	332,225		634,863
Total liabilities	332,225		634,863
Net assets available for benefits	$	780,088,151	$	719,559,176

See accompanying notes.

Retirement and Savings Plan for Amgen Manufacturing Limited LLC

Statement of Changes in Net Assets Available for Benefits


	Year Ended December 31,
	2024
Additions to (deductions from) net assets:
Employer contributions	$	21,287,553
Participant contributions	19,232,551
Rollover contributions	288,090
Interest and dividend income	5,416,829
Net realized/unrealized gains	46,915,641
Interest income on notes receivable from participants	1,174,893
Benefits paid	(33,154,339)
Investment and administrative fees	(632,243)
Net increase	60,528,975
Net assets available for benefits at beginning of year	719,559,176
Net assets available for benefits at end of year	$	780,088,151

See accompanying notes.

Retirement and Savings Plan for Amgen Manufacturing Limited LLC

Notes to Financial Statements

December 31, 2024

1. Description of the Plan

The following is a description of the Retirement and Savings Plan for Amgen Manufacturing Limited LLC (the Plan). Effective May 1, 2024, the Plan (formerly known as the Retirement and Savings Plan for Amgen Manufacturing, Limited) was amended solely to reflect that, as a result of an internal organizational restructuring that had no substantive impact on participants or Plan assets, the Plan sponsor is now Amgen Manufacturing Limited LLC (the successor entity to Amgen Manufacturing, Limited). The description below provides only general information, and accordingly, participants should refer to the Plan document for a more complete description of the Plan’s provisions.

General

The Plan was established effective May 1, 1992, and was amended and restated effective January 1, 2017, and subsequently amended, with the most recent amendment adopted on June 7, 2024. The Plan is a defined contribution plan covering substantially all Puerto Rico resident employees of Amgen Manufacturing Limited LLC (the Company), a wholly owned subsidiary of Amgen Inc. (Amgen). The Plan is intended to qualify under Section 1081.01 of the Puerto Rico Internal Revenue Code of 2011, as amended (the PR Code) (see Note 4, Income Tax Status) and section 407(d)(3)(A) of the Employee Retirement Income Security Act of 1974 (ERISA).

Contributions

Subject to certain limitations (as defined in the Plan), participants may elect to contribute up to 30% of their eligible compensation in pre-tax contributions and after-tax contributions or a combination of these types of contributions (together, Individual Contributions). A participant’s pre-tax contributions are subject to the PR Code and Plan limitations and could not exceed $15,000 in 2024. Participants may elect to contribute after-tax contributions beginning January 1 of the year following the year the participant was hired. Participant after-tax contributions are subject to the PR Code and Plan limitations and could not exceed $1,500 in 2024. Unless an employee has voluntarily enrolled in the Plan or has declined to participate in the Plan within the first 30 days of employment, all newly eligible participants are automatically enrolled in the Plan, and contributions equal to 5% of their eligible compensation are withheld and contributed to the Plan as pre-tax contributions; such contributions are automatically increased by 1% per year until their contributions reach 10% of their eligible compensation. Participants may elect to adjust, cease or resume their Individual Contributions at any time.

Participants who are at least age 50 by the close of the Plan year may also elect to make certain additional pre-tax Individual Contributions, referred to as catch-up contributions, that are subject to the PR Code and Plan limitations and could not exceed $1,500 in 2024. Participants may also contribute pre-tax and after-tax amounts representing distributions from certain other retirement plans qualified in Puerto Rico, referred to as rollover contributions (as defined in the Plan).

Each pay period, the Company makes a non-elective contribution for all eligible participants, whether or not they have elected to make Individual Contributions to the Plan, equal to 4% of each participant’s eligible compensation up to a maximum of $13,800 in 2024 (Core Contributions). In addition, the Company makes a contribution equal to amounts contributed by the participant as pre-tax contributions, including catch-up contributions, of up to 5% of eligible compensation (Matching Contributions). Matching Contributions could not exceed $15,000 in 2024 (or $16,500 for catch-up eligible participants).

Participants select the investments in which their Individual Contributions, including their Core Contributions and Matching Contributions (collectively, Company Contributions), are to be invested, electing among various alternatives, including Amgen common stock (Amgen stock). Participants may direct a maximum of 20% of contributions to be invested in Amgen stock. In addition, participants may transfer amounts among the investment options at any time, subject to certain limitations. Notwithstanding the foregoing, if 20% or more of the value of a participant’s Plan account is invested in Amgen stock, the Plan document provides that no transfers from other investment options can be made to invest in Amgen stock.

The accounts of participants who have not made an investment election are allocated to investments under a qualified default investment alternative, which is intended to be compliant with ERISA regulations. At any time, participants may elect to alter the investments in their accounts made under a qualified default investment alternative.

Vesting

Participants are immediately vested with respect to their Individual Contributions and Matching Contributions and earnings and losses (hereafter referred to as earnings) thereon. Participants hired prior to January 1, 2020, are also immediately vested

Retirement and Savings Plan for Amgen Manufacturing Limited LLC

Notes to Financial Statements (continued)

with respect to their Core Contributions and earnings thereon. Participants hired on or after January 1, 2020, vest in full with respect to their Core Contributions and earnings thereon after three years of service, as defined by the terms of the Plan, or upon reaching age 65 while employed by the Company, if earlier. If a participant ceases to be an employee before fully vesting in their account, the non-vested Core Contributions and earnings thereon of the participant’s account will be treated as a forfeiture, as defined by the terms of the Plan, on the earlier of (a) the date the participant incurs a five-year break in service, as defined by the terms of the Plan or, (b) the date the participant receives a distribution of the entire vested portion of their account.

Participant Accounts

Each participant’s account is credited with: (a) the participant’s Individual Contributions; (b) an allocation of Company Contributions; and (c) earnings. The benefit to which a participant is entitled is the benefit that can be provided from the participant’s account.

Plan Investments

Plan participants can invest in seven different asset classes as well as Amgen stock or can actively manage their account under a self-directed brokerage arrangement in which a wider array of investment options are available. The value of an investment in an asset class is determined by its underlying investment vehicles, which may include one or more of the following: mutual funds, collective trust funds and portfolios, which are separately managed exclusively for the benefit of Plan participants and their beneficiaries (separately managed portfolios). The separately managed portfolios are composed primarily of investments in publicly traded common and preferred stocks. The asset classes are designed to provide participants with choices among a variety of investment objectives.

Payments of Benefits

Subject to Plan limitations, upon termination of employment, including termination due to disability (as defined in the Plan) or retirement, a participant may elect to receive a full or partial distribution of his or her account balance in: (a) a single payment in cash; (b) a single distribution in full shares of Amgen stock (with any fractional shares paid in cash); (c) a single distribution paid in a combination of cash and full shares of Amgen stock; or (d) a rollover distribution to an eligible retirement plan.

Participants may also elect to maintain their account balance in the Plan subsequent to termination of employment, provided that their account balance is greater than $1,000.

If a participant dies before receiving the value of his or her account balance, the participant’s beneficiary may elect to receive the distribution of remaining funds from among the alternatives described above, subject to certain Plan limitations.

No withdrawals may be made from the Plan while a participant continues to be employed by the Company except in certain circumstances including, but not limited to, financial hardship, disability and attainment of age 59 1/2.

Notes Receivable from Participants

Subject to certain restrictions, a participant can have up to two loans outstanding at any one time from his or her Plan account with a combined maximum loan amount that may not exceed the lesser of: (a) 50% of the participant’s account balance or (b) $50,000 less certain adjustments, as applicable (as defined in the Plan). A participant’s loan is secured by his or her Plan account balance. Loans bear interest at fixed rates which, until changed by the Company, are based on the prime rate plus one percentage point as published in The Wall Street Journal, determined as of the last day of the calendar quarter preceding origination or such other rate as may be required by law. Loans are generally payable in installments over periods ranging from one to five years, unless the loan is used to acquire a principal residence for which the term of the loan may be up to 20 years. Principal and interest payments are allocated to the participant’s account.

Plan Termination

Although it has not expressed any intent to do so, the Company has the right under the Plan to terminate the Plan subject to the provisions of ERISA. Upon termination, participants would become fully vested in Core Contributions and receive distributions of their account balances.

Retirement and Savings Plan for Amgen Manufacturing Limited LLC

Notes to Financial Statements (continued)

Trustee and Custodians

Banco Popular de Puerto Rico is the Plan’s trustee. Bank of America, N.A. is the Plan’s custodian with respect to the self-directed brokerage arrangement and the Amgen common stock fund. Northern Trust Company, NA (Northern) is the Plan’s custodian with respect to the asset classes.

2. Summary of Significant Accounting Policies

Basis of Accounting

The accompanying financial statements are prepared on the accrual basis of accounting. Benefits to participants are recorded when paid.

Fair Value Measurement

The investments of the Plan are reported at fair value. Fair value is generally defined as the price that would be received to sell an asset or paid to transfer a liability (the exit price) in an orderly transaction between market participants at the measurement date (see Note 3, Fair Value Measurements).

Investment Income and Losses

Dividend income is recognized on the ex-dividend date, and interest income is recorded on an accrual basis. Unrealized gains and losses on investments are measured by the change in the difference between the fair value and cost of the securities held at the beginning of the year (or date purchased if acquired during the Plan year) and the end of the year. Realized gains and losses from security transactions are recorded based on the weighted-average cost of securities sold.

Notes Receivable from Participants

Notes receivable from participants are carried at their unpaid balance plus accrued but unpaid interest, as applicable.

Due from/to Brokers

Purchases and sales of investments are recorded on a trade-date basis. Amounts due from and due to brokers arise from unsettled sale and purchase transactions, respectively.

Use of Estimates

The preparation of financial statements in conformity with U.S. generally accepted accounting principles (GAAP) requires management to make estimates and assumptions that affect the amounts reported in the financial statements, accompanying notes and supplemental schedule. Actual results could differ from those estimates.

Risks and Uncertainties

The Plan provides for investment options representing varied combinations of equities (including Amgen stock), fixed income, and other investments. Investments, in general, particularly in securities, are exposed to various risks, such as interest rate, inflation, market and credit risks, among others. Market risk includes global events which could impact the value of investments, including securities, such as a pandemic or international conflict. Due to the level of risk associated with certain investments, including securities, it is at least reasonably possible that changes in the values of the Plan’s investments, including securities, will occur in the near term and that such changes could materially affect participant account balances and the amounts reported in the Plan’s financial statements.

3. Fair Value Measurements

The Plan uses various valuation approaches in determining the fair value of investments within a hierarchy that maximizes the use of observable inputs and minimizes the use of unobservable inputs by requiring that observable inputs be used when available. Observable inputs are inputs that market participants would use in pricing the investment based on market data obtained from independent sources. Unobservable inputs are inputs that reflect assumptions about the inputs that market participants would use in pricing the investment and are developed based on the best information available in the circumstances.

Retirement and Savings Plan for Amgen Manufacturing Limited LLC

Notes to Financial Statements (continued)

The fair value hierarchy is divided into three levels based on the source of inputs as follows:

Level 1 – Valuations based on unadjusted quoted prices in active markets for identical investments that the Plan has the ability to access

Level 2 – Valuations for which all significant inputs are observable, either directly or indirectly, other than Level 1 inputs

Level 3 – Valuations based on inputs that are unobservable and significant to the overall fair value measurement

The availability of observable inputs can vary among the various types of investments. To the extent that the valuation is based on models or inputs that are less observable or unobservable in the market, the determination of fair value requires more judgment. In certain cases, the inputs used for measuring fair value may fall into different levels of the fair value hierarchy. In such cases, for financial statement disclosure purposes, the level in the fair value hierarchy within which the fair value measurement is categorized is based on the lowest level of input used that is significant to the overall fair value measurement.

The following fair value hierarchy tables present information about each major class/category of the Plan’s investments measured at fair value:


	Fair value measurements at December 31, 2024, using
	Quoted prices in active markets for identical assets (Level 1)		Significant other observable inputs (Level 2)		Significant unobservable inputs (Level 3)		Total
Amgen stock	$	100,973,506	$	—	$	—	$	100,973,506
Cash and cash equivalents	43,702		—		—		43,702
Collective trust funds	—		577,297,941		—		577,297,941
Common and preferred stock	47,870,415		—		—		47,870,415
Mutual funds	16,198,902		—		—		16,198,902
Self-directed brokerage accounts	19,625,736		—		—		19,625,736
Total investments at fair value	$	184,712,261	$	577,297,941	$	—	$	762,010,202


	Fair value measurements at December 31, 2023, using
	Quoted prices in active markets for identical assets (Level 1)		Significant other observable inputs (Level 2)		Significant unobservable inputs (Level 3)		Total
Amgen stock	$	113,016,422	$	—	$	—	$	113,016,422
Cash and cash equivalents	30,340		—		—		30,340
Collective trust funds	—		492,330,408		—		492,330,408
Common and preferred stocks	73,030,315		—		—		73,030,315
Mutual funds	10,787,733		—		—		10,787,733
Self-directed brokerage accounts	13,439,222		—		—		13,439,222
Total investments at fair value	$	210,304,032	$	492,330,408	$	—	$	702,634,440

The fair values of substantially all common stocks (including Amgen stock), preferred stocks, mutual funds and underlying investments of self-directed brokerage accounts are valued using quoted market prices in active markets with no valuation adjustment.

Retirement and Savings Plan for Amgen Manufacturing Limited LLC

Notes to Financial Statements (continued)

Collective trust funds represent interests in pooled investment vehicles designed typically for collective investment of employee benefit trusts. The fair values of these investments are determined by reference to the net asset value per unit provided by the fund managers as the basis for current transactions.

4. Income Tax Status

The Plan received an opinion letter from the Puerto Rico Treasury Department (PRTD) dated February 26, 2018, with an effective date of January 1, 2017, stating that the Plan meets the requirements of Section 1081.01 of the PR Code and the regulations thereunder, and, therefore the related trust forming part of the Plan is exempt from taxation. Subsequently, seven amendments were made to the Plan, and the Plan received letters from the PRTD stating the PRTD has no objection to the first five of these amendments. The Company has submitted the sixth and seventh amendments to the PRTD requesting an opinion that the Plan remains in compliance with the PR Code and regulations thereunder. Once qualified, the Plan is required to operate in conformity with the PR Code to maintain its qualification.

For taxable year 2024, the Company believes the Plan satisfied, and operated in compliance with, the applicable requirements of the PR Code and therefore believes that the Plan, as amended, is qualified and the related trust is tax exempt. The Company has indicated that it currently intends to continue to take the necessary steps, if any, to maintain the Plan’s compliance with the applicable requirements of the PR Code.

5. Party-in-Interest Transactions

Parties-in-interest are certain entities defined under Department of Labor regulations, including Amgen, and other parties that provide services to the Plan, such as the trustees, custodians and investment managers. The Plan pays the custodians certain administrative and investment management fees, and the Company pays certain administrative fees on behalf of the Plan. The Plan invests in collective trust funds managed by Northern, certain of the Plan’s investment managers and other third parties and may invest in securities of entities that are parties-in-interest. The Plan also invests in shares of common stock of Amgen and receives dividends on those shares. Notes receivable from participants are also considered party-in-interest transactions.

Retirement and Savings Plan for Amgen Manufacturing Limited LLC

Notes to Financial Statements (continued)

6. Reconciliation of Financial Statements to the Form 5500

The reconciliation of net assets available for benefits per the financial statements to the Form 5500 consisted of the following:


	December 31,
	2024		2023
Net assets available for benefits per the financial statements	$	780,088,151	$	719,559,176

Amounts allocated to withdrawing participants	(9,000)		(27,778)
Deemed loans	(887,701)		(850,054)
Net assets per the Form 5500	$	779,191,450	$	718,681,344

The following is a reconciliation of expenses per the financial statements to the Form 5500:


	Year Ended December 31, 2024
Benefits paid	$	(33,154,339)
Investment and administrative fees	(632,243)
Total expenses per the financial statements	(33,786,582)
Amounts allocated to withdrawing participants at December 31, 2023	27,778
Amounts allocated to withdrawing participants at December 31, 2024	(9,000)
Deemed loans at December 31, 2023	850,054
Deemed loans at December 31, 2024	(887,701)
Total expenses per the Form 5500	$	(33,805,451)

Supplemental Schedule

Retirement and Savings Plan for Amgen Manufacturing Limited LLC

EIN: 98-0210484 Plan: #001

As of December 31, 2024

Schedule H, line 4i – Schedule of Assets (Held at End of Year)

Identity of Issue

Description of Investment

Current Value

Amgen stock*

Employer Securities 387,406 shares

100,973,506

Capital Preservation Asset Class:

Wells Fargo Stable Value Fund W*

Collective Trust Fund 1,402,332 units

90,775,341

NT Collective Short Term Investment Fund*

Collective Trust Fund 4,784,875 units

4,784,875

Total Capital Preservation Asset Class

95,560,216

Fixed Income Active Asset Class:

MetLife Core Plus Collective Fund*

Collective Trust Fund 780,607 units

7,868,517

Wellington Core Bond Plus Portfolio Collective Investment Trust II*

Collective Trust Fund 704,441 units

7,826,344

Northern Trust Global Investments Collective Daily Aggregate Bond Index Fund - Non Lending*

Collective Trust Fund 21,744 units

3,266,157

Schroder Global Strategic Bond Trust Class W*

Collective Trust Fund 221,861 units

2,442,691

NT Collective Short Term Investment Fund*

Collective Trust Fund 4 units

Total Fixed Income Active Asset Class

21,403,713

Fixed Income Index Asset Class:

Northern Trust Global Investments Collective Daily Aggregate Bond Index Fund - Non Lending*

Collective Trust Fund 940,926 units

141,336,449

NT Collective Short Term Investment Fund*

Collective Trust Fund 14 units

Total Fixed Income Index Asset Class

141,336,463

U.S. Equity Active Asset Class:

Northern Trust Collective Russell 1000 Value Index Fund - Non Lending*

Collective Trust Fund 16,013 units

10,215,354

NT Collective Russell 3000 Index Fund / Non Lending*

Collective Trust Fund 49,090 units

4,557,669

Amazon Inc.

Common and Preferred Stock 6,795 shares

1,490,755

Nvidia Corporation

Common and Preferred Stock 10159 shares

1,364,252

Microsoft Corporation

Common and Preferred Stock 3,135 shares

1,321,403

NT Collective Short Term Investment Fund*

Collective Trust Fund 971,898 units

971,898

Facebook Inc. Class A

Common and Preferred Stock 1,480 shares

866,555

ServiceNow, Inc.

Common and Preferred Stock 683 shares

724,062

Apple Inc.

Common and Preferred Stock 2,812 shares

704,181

Visa Inc. Class A

Common and Preferred Stock 2,214 shares

699,713

SS&C Technologies Holdings Inc.

Common and Preferred Stock 7,055 shares

534,628

Netflix, Inc.

Common and Preferred Stock 540 shares

481,313

Entegris Inc.

Common and Preferred Stock 4,522 shares

447,949

CVS Health Corporation

Common and Preferred Stock 9,920 shares

445,309

UnitedHealth Group Incorporated

Common and Preferred Stock 874 shares

442,122

Baxter International Inc.

Common and Preferred Stock 15,095 shares

440,170

Atlassian Corporation Class A

Common and Preferred Stock 1,771 shares

431,026

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of Issue

Description of Investment

Current Value

S&P Global Inc.

Common and Preferred Stock 837 shares

416,851

Shopify Inc. Class A

Common and Preferred Stock 3,904 shares

415,112

Intuit Inc.

Common and Preferred Stock 645 shares

405,383

Aon plc

Common and Preferred Stock 1,120 shares

402,259

Citigroup Inc.

Common and Preferred Stock 5,546 shares

390,383

Waste Management, Inc.

Common and Preferred Stock 1,932 shares

389,858

Gartner Inc.

Common and Preferred Stock 786 shares

380,793

Thermo Fisher Scientific Inc.

Common and Preferred Stock 729 shares

379,248

Canadian Pacific Kansas City Limited

Common and Preferred Stock 5,114 shares

370,100

Danaher Corporation

Common and Preferred Stock 1,592 shares

365,444

Novo Nordisk A/S

Common and Preferred Stock 4,195 shares

360,854

STERIS plc

Common and Preferred Stock 1,754 shares

360,552

Halozyme Therapeutics Inc.

Common and Preferred Stock 7,447 shares

356,041

Yum! Brands, Inc.

Common and Preferred Stock 2,651 shares

355,658

Dow Inc.

Common and Preferred Stock 8,744 shares

350,897

Clean Harbors Inc.

Common and Preferred Stock 1,513 shares

348,202

Wells Fargo & Company*

Common and Preferred Stock 4,922 shares

345,721

Datadog, Inc. Class A

Common and Preferred Stock 2,334 shares

333,505

Humana Inc.

Common and Preferred Stock 1,308 shares

331,853

Synopsys Inc.

Common and Preferred Stock 675 shares

327,618

Global Payments Inc.

Common and Preferred Stock 2,882 shares

322,957

Capital One Financial Corporation

Common and Preferred Stock 1,809 shares

322,581

Fresenius Medical Care

Common and Preferred Stock 14,095 shares

319,111

RB Global Inc.

Common and Preferred Stock 3,501 shares

315,825

Amphenol Corporation Class A

Common and Preferred Stock 4,544 shares

315,581

Ecolab Inc.

Common and Preferred Stock 1,344 shares

314,926

Workday, Inc.

Common and Preferred Stock 1,216 shares

313,764

Waste Connections Inc.

Common and Preferred Stock 1,808 shares

310,217

Dollar General Corporation

Common and Preferred Stock 4,032 shares

305,706

Merit Medical Systems Inc.

Common and Preferred Stock 3,155 shares

305,152

MSCI Inc.

Common and Preferred Stock 508 shares

304,805

Magna International Inc.

Common and Preferred Stock 7,264 shares

303,563

DexCom, Inc.

Common and Preferred Stock 3,840 shares

298,637

Spotify Technology S.A.

Common and Preferred Stock 665 shares

297,508

Euronet Worldwide Inc.

Common and Preferred Stock 2,864 shares

294,534

Sea Limited

Common and Preferred Stock 2,651 shares

281,271

Churchill Downs Inc.

Common and Preferred Stock 2,062 shares

275,359

Samsara Inc. Class A

Common and Preferred Stock 6,253 shares

273,194

Lear Corporation

Common and Preferred Stock 2,845 shares

269,422

Trimble Inc.

Common and Preferred Stock 3,809 shares

269,144

CarGurus Inc. Class A

Common and Preferred Stock 7,354 shares

268,715

Cognizant Technology Solutions Corporation Class A

Common and Preferred Stock 3,480 shares

267,612

Block, Inc.

Common and Preferred Stock 3,145 shares

267,294

Ametek Inc.

Common and Preferred Stock 1,453 shares

261,918

MetLife Inc.*

Common and Preferred Stock 3,189 shares

261,115

Equitable Holdings Inc.

Common and Preferred Stock 5,526 shares

260,661

Bank of America Corporation*

Common and Preferred Stock 5,916 shares

260,008

Charter Communications Inc.

Common and Preferred Stock 752 shares

257,763

Cloudflare, Inc.

Common and Preferred Stock 2,385 shares

256,817

American Express Company

Common and Preferred Stock 853 shares

253,162

Autodesk, Inc.

Common and Preferred Stock 854 shares

252,417

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of Issue

Description of Investment

Current Value

Alphabet Inc.

Common and Preferred Stock 1,314 shares

250,238

Bio-Techne Corporation

Common and Preferred Stock 3,401 shares

244,974

Intercontinental Exchange, Inc.

Common and Preferred Stock 1,623 shares

241,843

BWX Technologies Inc.

Common and Preferred Stock 2,167 shares

241,382

Bristol Myers Squibb

Common and Preferred Stock 4,248 shares

240,267

HealthEquity Inc.

Common and Preferred Stock 2,496 shares

239,491

Alight Inc. Class A

Common and Preferred Stock 33,459 shares

231,536

Amdocs Limited

Common and Preferred Stock 2,652 shares

225,791

Skyworks Solutions Inc

Common and Preferred Stock 2,524 shares

223,828

Brown & Brown Inc.

Common and Preferred Stock 2,191 shares

223,526

ASML Holding N.V.

Common and Preferred Stock 319 shares

221,093

Voya Financial Inc.

Common and Preferred Stock 3,208 shares

220,807

Okta Inc.

Common and Preferred Stock 2,790 shares

219,852

Medtronic PLC

Common and Preferred Stock 2,734 shares

218,392

Pfizer Inc.

Common and Preferred Stock 8,218 shares

218,024

Tyson Foods Inc.

Common and Preferred Stock 3,766 shares

216,319

Delta Air Lines, Inc.

Common and Preferred Stock 3,568 shares

215,864

Nu Holdings Limited

Common and Preferred Stock 20,612 shares

213,540

Ingredion Inc.

Common and Preferred Stock 1,528 shares

210,192

Shell plc

Common and Preferred Stock 3,331 shares

208,687

DoorDash, Inc. Class A

Common and Preferred Stock 1,230 shares

206,333

Salesforce.com Inc.

Common and Preferred Stock 613 shares

204,944

LKQ Corporation

Common and Preferred Stock 5,393 shares

198,193

Huntington Bancshares Inc.

Common and Preferred Stock 12,066 shares

196,314

Starbucks Corporation

Common and Preferred Stock 2,148 shares

196,005

Applovin Corporation Class A

Common and Preferred Stock 599 shares

193,974

IDEX Corporation

Common and Preferred Stock 918 shares

192,128

Charles River Laboratories International Inc.

Common and Preferred Stock 1,020 shares

188,292

Generac Holdings Inc.

Common and Preferred Stock 1,172 shares

181,719

Sensata Technologies BV Holding

Common and Preferred Stock 6,557 shares

179,662

Newell Brands Inc.

Common and Preferred Stock 17,875 shares

178,035

Viper Energy Inc.

Common and Preferred Stock 3,625 shares

177,879

Waystar Holding Corporation

Common and Preferred Stock 4,805 shares

176,344

TE Connectivity plc

Common and Preferred Stock 1,206 shares

172,422

PVH Corporation

Common and Preferred Stock 1,629 shares

172,267

Dynatrace Inc.

Common and Preferred Stock 3,168 shares

172,181

Uber Technologies, Inc.

Common and Preferred Stock 2,818 shares

169,982

Doximity Inc.

Common and Preferred Stock 3,172 shares

169,353

NOV Inc.

Common and Preferred Stock 11,274 shares

164,600

UGI Corporation

Common and Preferred Stock 5,819 shares

164,270

Henry Schein Inc.

Common and Preferred Stock 2,340 shares

161,928

Veracyte Inc.

Common and Preferred Stock 4,027 shares

159,469

Coherent Corporation

Common and Preferred Stock 1,681 shares

159,241

Heico Corporation Class A

Common and Preferred Stock 687 shares

158,726

The Cooper Companies, Inc.

Common and Preferred Stock 1,723 shares

158,395

Chewy Inc. Class A

Common and Preferred Stock 4,701 shares

157,436

Remitly Global Inc.

Common and Preferred Stock 6,933 shares

156,478

First American Financial Corporation

Common and Preferred Stock 2,497 shares

155,913

MACOM Technology Solutions Holdings Inc.

Common and Preferred Stock 1,193 shares

154,983

Roblox Corporation Class A

Common and Preferred Stock 2,605 shares

150,725

Huron Consulting Group Inc.

Common and Preferred Stock 1,156 shares

143,645

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of Issue

Description of Investment

Current Value

GlobalFoundries Inc.

Common and Preferred Stock 3,331 shares

142,933

AerCap Holdings N.V.

Common and Preferred Stock 1,488 shares

142,402

Blackbaud, Inc.

Common and Preferred Stock 1,921 shares

142,000

Dolby Laboratories Inc.

Common and Preferred Stock 1,811 shares

141,439

Cabot Corporation

Common and Preferred Stock 1,526 shares

139,339

Axon Enterprise, Inc.

Common and Preferred Stock 234 shares

139,071

Tandem Diabetes Care Inc.

Common and Preferred Stock 3,825 shares

137,777

Woodward Inc.

Common and Preferred Stock 796 shares

132,470

Snowflake Inc. Class A

Common and Preferred Stock 857 shares

132,329

ACV Auctions Inc. Class A

Common and Preferred Stock 6,060 shares

130,896

UBS Group AG

Common and Preferred Stock 4,273 shares

129,557

Prosperity Bancshares Inc.

Common and Preferred Stock 1,717 shares

129,376

QuidelOrtho Corporation

Common and Preferred Stock 2,877 shares

128,170

Ultragenyx Pharmaceutical Inc.

Common and Preferred Stock 3,033 shares

127,598

Curtiss Wright Corporation

Common and Preferred Stock 355 shares

125,979

nCino, Inc.

Common and Preferred Stock 3,701 shares

124,280

Toro Company

Common and Preferred Stock 1,514 shares

121,271

Dycom Industries Inc.

Common and Preferred Stock 696 shares

121,146

Belden Inc.

Common and Preferred Stock 1,072 shares

120,718

National Retail Properties Inc.

Common and Preferred Stock 2,937 shares

119,976

ACI Worldwide Inc.

Common and Preferred Stock 2,299 shares

119,341

Copart Inc.

Common and Preferred Stock 2,069 shares

118,740

Mid-American Apartment Communities Inc.

Common and Preferred Stock 759 shares

117,319

Itron Inc.

Common and Preferred Stock 1,071 shares

116,289

FMC Corporation

Common and Preferred Stock 2,288 shares

111,220

Kirby Corporation

Common and Preferred Stock 1,051 shares

111,196

Summit Materials Inc.

Common and Preferred Stock 2,181 shares

110,359

Madrigal Pharmaceuticals, Inc.

Common and Preferred Stock 349 shares

107,691

Advanced Energy Industries Inc.

Common and Preferred Stock 926 shares

107,073

Teleflex Inc.

Common and Preferred Stock 587 shares

104,474

WEX Inc.

Common and Preferred Stock 591 shares

103,614

Permian Resources Corporation

Common and Preferred Stock 7,205 shares

103,608

Alamos Gold Inc. Class A

Common and Preferred Stock 5,570 shares

102,711

IAC Inc.

Common and Preferred Stock 2,366 shares

102,069

Chart Industrials Inc.

Common and Preferred Stock 532 shares

101,527

FTI Consulting Inc.

Common and Preferred Stock 531 shares

101,490

BankUnited Inc.

Common and Preferred Stock 2,657 shares

101,418

John Bean Technologies Corporation

Common and Preferred Stock 789 shares

100,282

Iridium Communications Inc.

Common and Preferred Stock 3,455 shares

100,264

Graco Inc.

Common and Preferred Stock 1,184 shares

99,799

Carlisle Companies Inc.

Common and Preferred Stock 269 shares

99,218

Azekpany Inc.

Common and Preferred Stock 2,080 shares

98,738

TKO Group Holdings Inc.

Common and Preferred Stock 694 shares

98,624

Middleby Corporation

Common and Preferred Stock 720 shares

97,524

Rentokil Initial plc

Common and Preferred Stock 3,739 shares

94,671

Hexcel Corporation

Common and Preferred Stock 1,489 shares

93,360

Certara Inc.

Common and Preferred Stock 8,682 shares

92,463

Cimpress plc

Common and Preferred Stock 1,288 shares

92,375

Chemed Corporation

Common and Preferred Stock 172 shares

91,126

National Bank Holdings Corporation Class A

Common and Preferred Stock 2,098 shares

90,340

Encompass Health Corporation

Common and Preferred Stock 964 shares

89,025

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of Issue

Description of Investment

Current Value

Oceaneering International Inc.

Common and Preferred Stock 3,381 shares

88,176

AptarGroup Inc.

Common and Preferred Stock 555 shares

87,191

Supernus Pharmaceuticals Inc.

Common and Preferred Stock 2,411 shares

87,182

Ciena Corporation

Common and Preferred Stock 1,027 shares

87,100

JP Morgan Chase & Company

Common and Preferred Stock 363 shares

87,015

Sotera Health Company

Common and Preferred Stock 6,295 shares

86,116

Range Resources Corporation

Common and Preferred Stock 2,374 shares

85,417

Keysight Technologies Inc.

Common and Preferred Stock 531 shares

85,295

Pool Corporation

Common and Preferred Stock 247 shares

84,212

ASGN Inc.

Common and Preferred Stock 1,003 shares

83,590

On Semiconductor Corporation

Common and Preferred Stock 1,321 shares

83,289

Barnes Group Inc.

Common and Preferred Stock 1,721 shares

81,334

Hannon Armstrong Sustainable Infrastructure Capital Inc.

Common and Preferred Stock 3,019 shares

81,000

Prestige Consumer Healthcare Inc.

Common and Preferred Stock 1,036 shares

80,901

Knowles Corporation

Common and Preferred Stock 4,038 shares

80,477

Federal Signal Corporation

Common and Preferred Stock 857 shares

79,178

Box Inc. Class A

Common and Preferred Stock 2,503 shares

79,095

Omnicell Inc.

Common and Preferred Stock 1,775 shares

79,023

Tenable Holdings Inc.

Common and Preferred Stock 1,998 shares

78,681

KBR, Inc.

Common and Preferred Stock 1,353 shares

78,379

WisdomTree Investments Inc.

Common and Preferred Stock 7,451 shares

78,236

Applied Industrial Technologies Inc.

Common and Preferred Stock 306 shares

73,278

Wolverine World Wide Inc.

Common and Preferred Stock 3,293 shares

73,105

Markel Corporation Holding Company

Common and Preferred Stock 42 shares

72,502

Albany International Corporation Class A

Common and Preferred Stock 901 shares

72,053

Sprout Social, Inc. Class A

Common and Preferred Stock 2,344 shares

71,984

GFL Environmental Inc.

Common and Preferred Stock 1,545 shares

68,814

Haemonetics Corporation

Common and Preferred Stock 868 shares

67,773

Globus Medical, Inc. Class A

Common and Preferred Stock 816 shares

67,491

Sally Beauty Holdings Inc.

Common and Preferred Stock 6,405 shares

66,932

KB Home

Common and Preferred Stock 987 shares

64,866

Core & Main, Inc. Class A

Common and Preferred Stock 1,258 shares

64,045

Teledyne Technologies Inc.

Common and Preferred Stock 136 shares

63,122

SpringWorks Therapeutics Inc.

Common and Preferred Stock 1,747 shares

63,112

Sportradar Group

Common and Preferred Stock 3,490 shares

60,517

Acadia Healthcare Company Inc.

Common and Preferred Stock 1,499 shares

59,435

Elastic N.V.

Common and Preferred Stock 594 shares

58,854

8X8 Inc.

Common and Preferred Stock 21,091 shares

56,313

Jacobs Solutions Inc.

Common and Preferred Stock 421 shares

56,254

ZipRecruiter Inc. Class A

Common and Preferred Stock 7,539 shares

54,582

Axogen Inc.

Common and Preferred Stock 3,306 shares

54,483

Legend Biotech Corporation

Common and Preferred Stock 1,663 shares

54,114

Agios Pharmaceuticals Inc.

Common and Preferred Stock 1,631 shares

53,595

SLR Investment Corporation

Common and Preferred Stock 3,305 shares

53,409

J & J Snack Foods Corporation

Common and Preferred Stock 344 shares

53,365

Knight-Swift Transportation Holdings Inc. Class A

Common and Preferred Stock 1,004 shares

53,252

Carter Inc.

Common and Preferred Stock 933 shares

50,559

Consensus Cloud Solutions Inc.

Common and Preferred Stock 2,069 shares

49,366

N-Able Technologies International Inc.

Common and Preferred Stock 5,255 shares

49,082

United Community Bank Blairsville Georgia

Common and Preferred Stock 1,514 shares

48,917

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of Issue

Description of Investment

Current Value

Matthews International Corporation Class A

Common and Preferred Stock 1,745 shares

48,302

Trinet Group Inc.

Common and Preferred Stock 530 shares

48,108

CONMED Corporation

Common and Preferred Stock 695 shares

47,566

Skechers USA Inc. Class A

Common and Preferred Stock 705 shares

47,404

Nasdaq Inc.

Common and Preferred Stock 612 shares

47,314

Arvinas Inc.

Common and Preferred Stock 2,454 shares

47,043

Tronox Holdings PLC

Common and Preferred Stock 4,666 shares

46,987

Eagle Materials Inc.

Common and Preferred Stock 190 shares

46,884

Banner Corporation

Common and Preferred Stock 681 shares

45,470

Crescent Energy Company Class A

Common and Preferred Stock 3,103 shares

45,335

BRP Group Inc. Class A

Common and Preferred Stock 1,167 shares

45,233

WillScot Mobile Mini Holdings Corporation

Common and Preferred Stock 1,339 shares

44,790

Align Technology Inc.

Common and Preferred Stock 213 shares

44,413

STAG Industrial Inc.

Common and Preferred Stock 1,283 shares

43,391

Heartland Express Inc.

Common and Preferred Stock 3,863 shares

43,343

Axalta Coating Systems Limited

Common and Preferred Stock 1,249 shares

42,741

Cohen & Steers Inc.

Common and Preferred Stock 455 shares

42,015

TreeHouse Foods Inc.

Common and Preferred Stock 1,186 shares

41,664

Matson Inc.

Common and Preferred Stock 308 shares

41,531

Wabtec Corporation

Common and Preferred Stock 216 shares

40,951

Exact Sciences Corporation

Common and Preferred Stock 712 shares

40,007

JBG SMITH Properties

Common and Preferred Stock 2,514 shares

38,640

Pacific Premier Bancorp Inc.

Common and Preferred Stock 1,540 shares

38,377

GXO Logistics Inc.

Common and Preferred Stock 879 shares

38,237

Littelfuse Inc.

Common and Preferred Stock 161 shares

37,940

Silgan Holdings Inc.

Common and Preferred Stock 726 shares

37,788

Northern Oil & Gas Inc.

Common and Preferred Stock 1,016 shares

37,755

Fox Factory Holding Corporation

Common and Preferred Stock 1,246 shares

37,716

Flowserve Corporation

Common and Preferred Stock 632 shares

36,353

First Interstate BancSystem

Common and Preferred Stock 1,095 shares

35,555

Northwestern Corporation

Common and Preferred Stock 609 shares

32,557

ALLETE Inc.

Common and Preferred Stock 499 shares

32,335

Monro Inc.

Common and Preferred Stock 1,299 shares

32,215

WSFS Financial Corporation

Common and Preferred Stock 601 shares

31,931

Healthpeak OP, LLC

Common and Preferred Stock 1,531 shares

31,033

Mercury Systems Inc.

Common and Preferred Stock 730 shares

30,660

Texas Capital Bancshares Inc.

Common and Preferred Stock 392 shares

30,654

Americold Realty Trust, Inc.

Common and Preferred Stock 1,402 shares

30,003

Amentum Holdings, Inc.

Common and Preferred Stock 1,389 shares

29,211

NCR Corporation

Common and Preferred Stock 1,971 shares

27,279

Boston Properties Inc.

Common and Preferred Stock 365 shares

27,141

Dyne Therapeutics, Inc.

Common and Preferred Stock 1,128 shares

26,576

Patterson-UTI Energy Inc.

Common and Preferred Stock 3,203 shares

26,457

1-800-FLOWERS.COM Inc. Class A

Common and Preferred Stock 3,075 shares

25,123

IPG Photonics Corporation

Common and Preferred Stock 340 shares

24,725

J2 Global Inc.

Common and Preferred Stock 443 shares

24,073

Sonos Inc.

Common and Preferred Stock 1,594 shares

23,974

Nevro Corporation

Common and Preferred Stock 6,419 shares

23,879

StandardAero, Inc.

Common and Preferred Stock 958 shares

23,720

Rogers Corporation

Common and Preferred Stock 228 shares

23,167

Berkshire Hills Bancorp Inc.

Common and Preferred Stock 807 shares

22,943

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of Issue

Description of Investment

Current Value

Transmedics Group Inc.

Common and Preferred Stock 338 shares

21,074

Mednax Inc.

Common and Preferred Stock 1,508 shares

19,785

Nuvalent, Inc. Class A

Common and Preferred Stock 250 shares

19,570

Columbus McKinnon Corporation

Common and Preferred Stock 443 shares

16,497

Insight Enterprises, Inc.

Common and Preferred Stock 108 shares

16,427

Designer Brands Inc. Class A

Common and Preferred Stock 2,990 shares

15,967

Herbalife Nutrition Limited

Common and Preferred Stock 2,136 shares

14,290

eHealth Inc.

Common and Preferred Stock 1,190 shares

11,186

Nu Skin Enterprises Inc. Class A

Common and Preferred Stock 1,211 shares

8,344

Safehold Inc.

Common and Preferred Stock 435 shares

8,039

Total U.S. Equity Active Asset Class

63,615,336

U.S. Equity Index Asset Class:

NT Collective Russell 3000 Index Fund / Non Lending*

Collective Trust Fund 1,899,107 units

176,320,690

NT Collective Short Term Investment Fund*

Collective Trust Fund 25 units

Total U.S. Equity Index Asset Class

176,320,715

International Equity Active Asset Class:

Mawer International Equity Collective Investment Trust Class B*

Collective Trust Fund 1,575,932 units

27,927,716

Polaris Capital Management Collective Investment Trust International Value Collective Fund*

Collective Trust Fund 2,211,444 units

26,838,086

Reliance Trust Institutional Retirement Trust GQG Partners International Equity Fund Series 11 Class C*

Collective Trust Fund 1,278,791 units

20,371,142

Dodge & Cox International Stock Fund

Mutual Fund 324,627 shares

16,198,902

Wilmington Trust Collective Investment Trust / Jennison International Equity Opportunities CIT Class J*

Collective Trust Fund 1,573,351 units

15,746,099

NT Collective MSCI All Country World Index (ACWI) ex/US Index Fund / Non Lending*

Collective Trust Fund 47,044 units

10,619,923

NT Collective Short Term Investment Fund*

Collective Trust Fund 3,996 units

3,996

Total International Equity Active Asset Class

117,705,864

International Equity Index Asset Class:

NT Collective MSCI All Country World Index (ACWI) ex/US Index Fund / Non Lending*

Collective Trust Fund 123,364 units

25,422,921

Total International Equity Index Asset Class

25,422,921

Participant Self-Directed Accounts

Various Investments

19,625,736

Notes Receivable from Participants*

Interest Rate 4.25% - 9.50%

17,220,197

Other

ML Vanguard Federal Money Market Forfeiture / Settlement*

Cash and Cash Equivalents

34,702

BIF Money Fund*

Cash and Cash Equivalents

9,000

NT Collective Short Term Investment Fund*

Collective Trust Fund 2,031 units

2,031

Total Other

45,733

Schedule H, line 4i – Schedule of Assets (Held at End of Year) (continued)

Identity of Issue

Description of Investment

Current Value

Grand Total

779,230,400

* Indicates party-in-interest

RETIREMENT AND SAVINGS PLAN FOR

AMGEN MANUFACTURING LIMITED LLC

INDEX TO EXHIBIT


Consent of Independent Registered Public Accounting Firm						Exhibit 23.1

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the trustees (or other persons who administer the employee benefit plan) have duly caused this annual report to be signed on its behalf by the undersigned hereunto duly authorized.

Retirement and Savings Plan for

Amgen Manufacturing Limited LLC

(Name of Plan)

Date:

June 12, 2025

By:

/s/ PETER H. GRIFFITH

Peter H. Griffith

Executive Vice President and Chief Financial Officer

Amgen Manufacturing Limited LLC