Mail Stop 03-06 May 11, 2005 Marvin A Sackner, M.D. Chief Executive Officer Non-Invasive Monitoring Systems, Inc. 1666 Kennedy Causeway Avenue Suite 400 North Bay Village, FL 33141 Re: Non-Invasive Monitoring Systems, Inc. Form 10-KSB for the fiscal year ended July 31, 2004 Filed October 29, 2004 File No. 0-13176 Dear Mr. Sackner: We have completed our review of your Form 10-KSB and related filings and do not, at this time, have any further comments. Sincerely, Martin F. James Senior Assistant Chief Accountant