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Exhibit 21.1

Subsidiaries of the Registrant

Listed below are majority-owned subsidiaries of Cardinal Health, Inc. as of June 30, 2024. Subsidiaries excluded from the list below would not, considered in the aggregate as a single subsidiary, constitute a “significant subsidiary” of Cardinal Health, Inc. as that term is defined in Rule 1-02(w) of SEC Regulation S-X.

Subsidiary Name						State/Jurisdiction of Incorporation
A+ Secure Packaging, LLC						Tennessee
Aero-Med, LLC						Connecticut
Allegiance Corporation						Delaware
Cardinal Health 2, LLC						Nevada
Cardinal Health 3, LLC						Delaware
Cardinal Health 5, LLC						Delaware
Cardinal Health 6, Inc.						Nevada
Cardinal Health 7, LLC						Delaware
Cardinal Health 23, LLC						Nevada
Cardinal Health 23 Funding, LLC						Nevada
Cardinal Health 100, LLC						Indiana
Cardinal Health 104 LP						Ohio
Cardinal Health 105, LLC						Ohio
Cardinal Health 107, LLC						Ohio
Cardinal Health 108, LLC						Delaware
Cardinal Health 110, LLC						Delaware
Cardinal Health 112, LLC						Delaware
Cardinal Health 113, LLC						Wisconsin
Cardinal Health 114, Inc.						Delaware
Cardinal Health 115, LLC						Ohio
Cardinal Health 116, LLC						Delaware
Cardinal Health 118, LLC						Delaware
Cardinal Health 119, LLC						Delaware
Cardinal Health 121, LLC						Delaware
Cardinal Health 122, LLC						Delaware
Cardinal Health 123, LLC						Delaware
Cardinal Health 124, LLC						Delaware
Cardinal Health 126, LLC						Delaware
Cardinal Health 127, Inc.						Kansas
Cardinal Health 132, LLC						Delaware
Cardinal Health 200, LLC						Delaware
Cardinal Health 201, LLC						Delaware
Cardinal Health 222 (Thailand) Ltd.						Thailand
Cardinal Health 247, Inc.						Colorado
Cardinal Health 249, LLC						Delaware
Cardinal Health 414, LLC						Delaware
Cardinal Health Australia 503 Pty. Ltd.						Australia
Cardinal Health Austria 504 GmbH						Austria
Cardinal Health Belgium 505 BVBA						Belgium
Cardinal Health Canada Inc.						Canada
Cardinal Health Canada Holdings Cooperative U.A.						Netherlands
Cardinal Health Chile Limitada						Chile
Cardinal Health Colombia S.A.S.						Colombia
Cardinal Health do Brasil Ltd.						Brazil
Cardinal Health D.R. 203 II Ltd.						Bermuda
Cardinal Health Denmark ApS						Denmark

Subsidiary Name						State/Jurisdiction of Incorporation
Cardinal Health Finland Oy						Finland
Cardinal Health Foundation						Ohio
Cardinal Health France 506 SAS						France
Cardinal Health Funding, LLC						Nevada
Cardinal Health Germany 507 GmbH						Germany
Cardinal Health Germany Manufacturing GmbH						Germany
Cardinal Health International India Private Limited						India
Cardinal Health International Philippines, Inc.						Philippines
Cardinal Health IPS, LLC						Delaware
Cardinal Health Ireland 419 Designated Activity Company						Ireland
Cardinal Health Ireland 508 Limited						Ireland
Cardinal Health Ireland Unlimited Company						Ireland
Cardinal Health Italy 509 Srl						Italy
Cardinal Health K.K.						Japan
Cardinal Health Korea Limited						Korea
Cardinal Health Malaysia 211 Sdn. Bhd.						Malaysia
Cardinal Health Malta 212 Limited						Malta
Cardinal Health Managed Care Services, LLC						Delaware
Cardinal Health Mexico 514 S. de R.L. de C.V.						Mexico
Cardinal Health Middle East FZ-LLC						United Arab Emirates
Cardinal Health Netherlands 502 B.V.						Netherlands
Cardinal Health Pharmaceutical Contracting, LLC						Delaware
Cardinal Health Pharmacy Services, LLC						Delaware
Cardinal Health P.R. 120, Inc.						Puerto Rico
Cardinal Health P.R. 218, Inc.						Puerto Rico
Cardinal Health P.R. 220, LLC						Puerto Rico
Cardinal Health Singapore 225 Pte. Ltd.						Singapore
Cardinal Health Spain 511 S.L.						Spain
Cardinal Health Sweden 512 A.B.						Sweden
Cardinal Health Switzerland 515 GmbH						Switzerland
Cardinal Health Systems, Inc.						Ohio
Cardinal Health Technologies, LLC						Nevada
Cardinal Health Technologies Switzerland GmbH						Switzerland
Cardinal Health U.K. 432 Limited						United Kingdom
Cardinal Health Medical Equipment Consulting (Shanghai) Co., Ltd.						China
Cirpro de Delicias S.A. de C.V.						Mexico
Convertors de Mexico S.A. de C.V.						Mexico
Cordis Corporation						Florida
Cordis (Shanghai) Medical Devices Co., Ltd.						China
Cornerstone Rheumatology, L.P.						Tennessee
Covidien Manufacturing Solutions, S.A.						Costa Rica
EPIC Insurance Company						Vermont
Especialidades Medicas Kenmex S.A. de C.V.						Mexico
GastroGPO, LLC						Delaware

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Subsidiary Name						State/Jurisdiction of Incorporation
Gastrologix, LLC						Delaware
Griffin Capital, LLC						Nevada
Innovative Therapies, LLC						Delaware
Instant Diagnostic Systems, Inc.						Alabama
Kendall-Gammatron Limited						Thailand
KPR Australia Pty. Ltd.						Australia
KPR U.S., LLC						Delaware
Leader Drugstores, Inc.						Delaware
Ludlow Technical Products Canada, Ltd.						Canada
Marin Apothecaries						California
Medicine Shoppe International, Inc.						Delaware
Mediquip Sdn. Bhd.						Malaysia
MosaicGPO, LLC						Delaware
mscripts, LLC						Delaware
One Cloverleaf, LLC						Delaware
Pinnacle Intellectual Property Services, Inc.						Nevada
Pinnacle Intellectual Property Services-International, Inc.						Nevada
Quiroproductos de Cuauhtemoc S. de R.L. de C.V.						Mexico
RainTree GPO, LLC						Delaware
Renal Purchasing Group, LLC						Tennessee
RGH Enterprises, LLC						Ohio
Rxealtime, Inc.						Nevada
Sonexus Health, LLC						Texas
Specialty Networks Urology Registry, LLC						Delaware
The Harvard Drug Group, L.L.C.						Michigan
Traverse GPO, LLC						Delaware
United Rheumatology, LLC						Delaware
UroGPO, LLC						Delaware
WaveMark, Inc.						Delaware