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Exhibit 31.1

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CERTIFICATIONS

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I, Richard L. Feinstein, certify that:

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1. I have reviewed this Amendment No. 1 to the Annual Report on Form 10-K of Enzon Pharmaceuticals, Inc.;

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2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.

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Date: April 28, 2025

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/s/ Richard L. Feinstein

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Richard L. Feinstein

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Chief Executive Officer, Chief Financial Officer, and Secretary

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(Principal Executive Officer and Principal Financial Officer)

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