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Corporate Presentation

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Developing the next generation of targeted therapies

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Higher potency payloads with cancer-specific targeting

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Upcoming data milestones

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Radiopharmaceutical therapy poised to revolutionize oncology treatment Perspective’s pipeline and platform has the potential to significantly expand the breadth of tumors addressed by RPT

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Perspective’s Innovative Platform

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Perspective’s radiopharmaceutical platform optimized for a broader therapeutic window

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Perspective’s proprietary chelator has been optimized for lead-based RPTs

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Proposed mechanism of action for 212Pb

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Rationale for synergy with immune checkpoint inhibitors

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Supply Chain and Manufacturing Infrastructure

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On-demand order fulfillment at regional sites to deliver finished products

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Neuroendocrine Tumors: VMT-⍺-NET

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Trial design: [212Pb]VMT-⍺-NET Phase 1/2a for PRRT naïve neuroendocrine tumors

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Compelling anti-tumor activity

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Durable disease control across all doses

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Signal of sustained anti-tumor activity

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Best-in-class safety profile1

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Select adverse events of special interest

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Mild and generally transient blood creatinine increase

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[212Pb]VMT-α-NET was well-tolerated and demonstrated compelling anti-tumor activity

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Melanoma Program: VMT01/02

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Trial design: [212Pb]VMT01 Phase 1/2a for metastatic melanoma

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Treatment emergent adverse events (all grades, occurring in ≥ 2 patients)

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PSV359 is active against FAP-α expression on tumor and on stroma

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Trial design: [212Pb]PSV359 Phase 1/2a trial

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General Corporate Information

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Abbreviations

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APPENDIX

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NETs trials

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Potential for differentiated profile based on molecular design

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Durable disease control across all doses

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Refractory metastatic melanoma trials

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Daily production at regional sites ensures supply of ready-to-administer product

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Perspective’s pre-targeting platform