Please wait

Exhibit 21.1

Significant Subsidiaries of the Company

Listed below are the significant subsidiaries (as defined in Rule 1-02(w) of Regulation S-X) of UnitedHealth Group Incorporated as of December 31, 2025. This list does not include Company subsidiaries that did not meet the conditions required to be deemed a significant subsidiary as of December 31, 2025.

Name of Entity			State of Jurisdiction or Domicile			Doing Business As
Collaborative Care Holdings, LLC			Delaware
Optum, Inc.			Delaware
OptumHealth Holdings, LLC			Delaware
OptumRx Administrative Services, LLC			Texas			Alaska Business License #2143946
OptumRx Group Holdings, Inc.			Delaware
OptumRx Holdings I, LLC			Delaware
UHIC Holdings, Inc.			Delaware			OneNet PPO
United HealthCare Services, Inc.			Minnesota			AmeriChoice EverCare Health Professionals Review Healthmarc HealthPro Institute for Human Resources UHC Management Company UHC Management Company, Inc. United Health Care United HealthCare United HealthCare Corporation United HealthCare Management Company, Inc. United HealthCare Management Services United HealthCare Services of Minnesota United HealthCare Services of Minnesota, Inc. United Resource Networks United Resource Networks, Inc. UnitedHealthcare UnitedHealthcare Medicare Customer Service Center UnitedHealthcare MedicareStore
UnitedHealthcare Insurance Company			Connecticut			UnitedHealthcare Community Plan
UnitedHealthcare, Inc.			Delaware