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Exhibit 107

Calculation of Filing Fee Tables

Form S-3

(Form Type)

Vertex Pharmaceuticals Incorporated

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

 

     

Security

Type

   

Security Class

Title(1)

   

Fee

Calculation

or Carry

Forward Rule  

    Amount
Registered  		    Proposed
Maximum
Offering Price  
Per Unit		    Maximum  
Aggregate
Offering Price  		   

Fee

Rate

    Amount of
Registration  
Fee
Newly Registered Securities
Fees to Be Paid    Equity    Common stock, $0.01 par value per share   

Rule 456(b)

and

Rule 457(r)(3) 

    (2)    (2)    (2)    (3)    (3)
     Equity    Preferred stock, $0.01 par value per share   

Rule 456(b)

and

Rule 457(r)(3) 

    (2)    (2)    (2)    (3)    (3)
     Debt    Debt securities   

Rule 456(b)

and

Rule 457(r)(3) 

    (2)    (2)    (2)    (3)    (3)
     Other    Warrants   

Rule 456(b)

and

Rule 457(r)(3) 

    (2)    (2)    (2)    (3)    (3)
     Other    Subscription rights   

Rule 456(b)

and

Rule 457(r)(3) 

    (2)    (2)    (2)    (3)    (3)
     Other    Purchase contracts   

Rule 456(b)

and

Rule 457(r)(3) 

    (2)    (2)    (2)    (3)    (3)
     Other   

Purchase

units

   

Rule 456(b)

and

Rule 457(r)(3) 

    (2)    (2)    (2)    (3)    (3)
Fees Previously Paid    N/A    N/A    N/A    N/A    N/A    N/A         N/A

 

(1)

Securities registered hereunder may be sold separately, together or as units with other securities registered hereunder.

(2)

Omitted pursuant to Form S-3 General Instruction II.E. We are registering an indeterminate number of shares of common stock or preferred stock and amount of debt securities as may be issued upon conversion, exchange or exercise, as applicable, of any preferred stock, debt securities, warrants or subscription rights or settlement of any purchase contracts or purchase units, including such shares of common stock or preferred stock as may be issued pursuant to anti-dilution adjustments determined at the time of offering.

(3)

In accordance with Rules 456(b) and 457(r) under the Securities Act, the registrant is deferring payment of the entire registration fee.