<?xml version="1.0"?>
<notificationOfRemoval>

    <schemaVersion>X0203</schemaVersion>

    <exchange>
        <cik>0001354457</cik>
        <entityName>Nasdaq Stock Market LLC</entityName>
    </exchange>

    <issuer>
        <cik>0000882361</cik>
        <entityName>Aptose Biosciences Inc.</entityName>
        <fileNumber>001-32001</fileNumber>
        <address>
            <street1>5955 Airport Road, Suite 228</street1>
            <street2></street2>
            <city>Mississauga</city>
            <stateOrCountryCode>A6</stateOrCountryCode>
            <stateOrCountry>ONTARIO, CANADA</stateOrCountry>
            <zipCode>L4V 1R9</zipCode>
        </address>
        <telephoneNumber>4152184035</telephoneNumber>
    </issuer>

    <descriptionClassSecurity>Common Shares</descriptionClassSecurity>

    <ruleProvision>17 CFR 240.12d2-2(b)</ruleProvision>

    <signatureData>
        <signatureName>Aravind Menon</signatureName>
        <signatureTitle>Hearings Advisor</signatureTitle>
        <signatureDate>2025-07-21</signatureDate>
    </signatureData>
</notificationOfRemoval>