BioCryst Pharmaceuticals, Inc.
    4505 Emperor Blvd., Suite 200
    Durham, North Carolina 27703
    (919) 859-1302
     
    
    
    
    
    
    May 12, 2020
    
    
    
    
     
    
    
    
    VIA EDGAR
     
      
    Securities and Exchange Commission
      Division of Corporation Finance
      100 F Street, N.E.
      Washington, DC 20549
      Attn:  Courtney Lindsay and Celeste Murphy
     
    
    
        
          | 
 | Re: | BioCryst Pharmaceuticals, Inc. | 
    
    Registration Statement on Form S-3 (File No. 333-237820)
    Filed April 24, 2020
      
    
    Ladies and Gentlemen:
     
    
    Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, BioCryst Pharmaceuticals, Inc., a Delaware corporation (the
      “Company”), hereby respectfully requests that the effective time of the above referenced Registration Statement on Form S-3 filed by the Company (the “Registration Statement”) be accelerated to 4:00 p.m., Eastern Daylight Time, on May 14, 2020 or as
      soon thereafter as practicable.
    
    
     
    
    [Signature page follows]
    
    
    
    
        
          |  | Very truly yours, | 
        
          |  |  | 
        
          |  | BioCryst Pharmaceuticals, Inc. | 
        
          |  |  | 
        
          |  | /s/ Alane Barnes                                                      
 | 
        
          |  | Alane Barnes | 
        
          |  | Senior Vice President and Chief Legal Officer | 
    
    
       
    cc:          Robyn Zolman, Gibson, Dunn & Crutcher LLP