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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13D/A 0000899140-22-000088 0001577524 XXXXXXXX LIVE 15 Ordinary Shares, par value 50 pence per share 03/25/2025 false 0000897448 023111206 Amarin Corporation PLC/UK One Central Plaza, 5th Floor 36 Dame Street Dublin 2 L2 D02 EF64 Mark DiPaolo 203-302-2330 Sarissa Capital Management LP 660 Steamboat Road, 3rd Floor Greenwich CT 06830 0001577524 Sarissa Capital Management LP WC DE 0 33470000 0 33470000 33470000 N 8.08 PN 0001361754 Alexander J Denner AF X1 0 33470000 0 33470000 33470000 N 8.08 IN Ordinary Shares, par value 50 pence per share Amarin Corporation PLC/UK One Central Plaza, 5th Floor 36 Dame Street Dublin 2 L2 D02 EF64 This Amendment No. 15 to Schedule 13D ("Amendment No. 15") relates to American Depositary Shares ("ADS(s)"), each ADS presently representing one ordinary share, par value 50 pence per share (the "Ordinary Shares"), issued by Amarin Corporation plc, a company incorporated under the laws of England and Wales (the "Issuer"), and amends the initial statement on Schedule 13D filed with the Securities and Exchange Commission (the "SEC") on January 24, 2022 (the "Initial Schedule 13D"), as amended by Amendment No. 1 to Schedule 13D filed on June 3, 2022, Amendment No. 2 to Schedule 13D filed on June 16, 2022, Amendment No. 3 to Schedule 13D filed on October 11, 2022, Amendment No. 4 to Schedule 13D filed on January 11, 2023, Amendment No. 5 to Schedule 13D filed on January 19, 2023, Amendment No. 6 to Schedule 13D filed on February 8, 2023, Amendment No. 7 to Schedule 13D filed on February 10, 2023, Amendment No. 8 to Schedule 13D filed on February 14, 2023, Amendment No. 9 to Schedule 13D filed on February 15, 2023, Amendment No. 10 to Schedule 13D filed on February 21, 2023, Amendment No. 11 to Schedule 13D filed on February 27, 2023, Amendment No. 12 to Schedule 13D filed on February 28, 2023, Amendment No. 13 to Schedule 13D filed on September 5, 2023 and Amendment No. 14 to Schedule 13D filed on December 5, 2023 (the Initial Schedule 13D as so amended, the "Schedule 13D"). All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D. This Amendment No. 15 is being filed to amend Item 4 and Item 5(a) as follows: On March 25, 2025, Mr. Mark DiPaolo, a member of Issuer's board of directors (the "Board"), notified the Issuer that he does not intend to stand for reelection to the Board at the Issuer's 2025 Annual Meeting of Shareholders. The Reporting Persons may be deemed to beneficially own, in the aggregate, 33,470,000 Shares representing approximately 8.08% of the outstanding Shares. Percentages of the outstanding Shares are based upon the 414,186,296 Shares outstanding as of February 28, 2025, including 405,383,488 ADSs, and 8,802,808 Ordinary Shares, as set forth in the Form 10-K of the Issuer filed with the SEC on March 12, 2025. Sarissa Capital Management LP /s/ Mark DiPaolo Mark DiPaolo/General Counsel 03/25/2025 Alexander J Denner /s/ Alexander J Denner Alexander J Denner 03/25/2025