| | | | | | | | | | | | | | | | | |
| Twelve months ended |
| December 31 |
| 2020 | | 2019 | | 2018 |
| GAAP net income | $ | 603.4 | | | $ | 2,404.3 | | | $ | 77.6 | |
| Before tax adjustments: | | | | | |
| Cost of sales: | | | | | |
| Share-based compensation | 12.4 | | | 14.2 | | | 16.0 | |
| Fair value adjustment in inventory acquired | 22.9 | | | — | | | — | |
| Restructuring related expenses | — | | | — | | | 5.8 | |
| Research and development expense: | | | | | |
| Share-based compensation | 68.6 | | | 61.7 | | | 57.4 | |
| Fair value adjustment in inventory acquired | 4.9 | | | — | | | — | |
| Upfront payments related to licenses and other strategic agreements | — | | | 103.4 | | | 26.7 | |
| Restructuring related expenses | — | | | — | | | 0.1 | |
| Selling, general and administrative expense: | | | | | |
| Share-based compensation | 179.7 | | | 161.1 | | | 129.6 | |
| Restructuring related expenses | — | | | — | | | 19.4 | |
| Litigation charges | 21.6 | | | 0.1 | | | 13.0 | |
| Gain on sale of asset | — | | | — | | | (3.5) | |
| Acquired in-process research and development | — | | | (4.1) | | | 1,183.0 | |
| Amortization of purchased intangible assets | 253.7 | | | 309.6 | | | 320.1 | |
| Change in fair value of contingent consideration | 61.2 | | | 11.6 | | | 116.5 | |
| Acquisition-related costs | 117.6 | | | — | | | — | |
| Restructuring expenses | 10.3 | | | 12.0 | | | 25.5 | |
| Impairment of intangible assets | 2,053.3 | | | — | | | — | |
| Gain on sale of asset | (14.8) | | | — | | | — | |
| Investment income (expense): | | | | | |
| (Gains) and losses related to strategic equity investments | (26.6) | | | (59.7) | | | (43.1) | |
| Other income and (expense): | | | | | |
| Gain related to modification of purchase option | — | | | (32.0) | | | — | |
| Restructuring related expenses | — | | | — | | | (0.1) | |
| Adjustments to income tax expense | (547.2) | | | (584.9) | | | (145.4) | |
| Non-GAAP net income | $ | 2,821.0 | | | $ | 2,397.3 | | | $ | 1,798.6 | |
| | | | | |
| GAAP earnings per common share - diluted | $ | 2.72 | | | $ | 10.70 | | | $ | 0.35 | |
| Non-GAAP earnings per common share - diluted | $ | 12.51 | | | $ | 10.53 | | | $ | 7.92 | |
| | | | | |
| Shares used in computing diluted earnings per common share (GAAP) | 222.0 | | | 224.8 | | | 224.5 | |
| Shares used in computing diluted earnings per common share (non-GAAP) | 225.5 | | | 227.6 | | | 227.1 | |