Exhibit 8.1
GROUP SUBSIDIARIES*
At December 31, 2025 | | Country | | Percentage of voting |
Wholly owned subsidiaries | | | | |
Alexion Pharmaceuticals, Inc. | | United States | | 100 |
Alexion Pharma International Operations Limited Company | | Ireland | | 100 |
AstraZeneca AB | | Sweden | | 100 |
AstraZeneca Biotech AB | | Sweden | | 100 |
AstraZeneca Finance and Holdings Inc. | | United States | | 100 |
AstraZeneca Finance LLC | | United States | | 100 |
AstraZeneca Intermediate Holdings Limited | | United Kingdom | | 100 |
AstraZeneca Pharmaceuticals LP | | United States | | 100 |
AstraZeneca Treasury Limited | | United Kingdom | | 100 |
AstraZeneca UK Limited | | United Kingdom | | 100 |
Zeneca Holdings Inc. | | United States | | 100 |
* Subsidiary companies which would be deemed to be a “significant subsidiary” in accordance with rule 1-02(w) of Regulation S-X as at December 31, 2025.