Free Writing Prospectus filed pursuant to Rule 433
Relating to the Preliminary Prospectus Supplement dated February 25, 2026 to the Prospectus dated March 19, 2024
Registration Statement No. 333-278067
AstraZeneca Finance LLC
$650,000,000 4.000% Notes due 2031
$600,000,000 4.300% Notes due 2033
$750,000,000 4.600% Notes due 2036
Final Term Sheet
| Issuer: | AstraZeneca Finance LLC |
| Guarantor: | AstraZeneca PLC |
| Trade Date: | February 25, 2026 |
| Settlement Date: | March 2, 2026 (T+3) |
| Expected Ratings: | Moody’s: A1; S&P: A+ |
$650,000,000 4.000% Notes due 2031:
| Security Type: | Senior Notes |
| Aggregate Principal Amount: | $650,000,000 |
| Maturity Date: | March 2, 2031 |
| Coupon: | 4.000% |
| Benchmark Treasury: | 3.750% due January 31, 2031 |
| Benchmark Treasury Price and Yield: | 100-18+, 3.620% |
| Spread to Benchmark Treasury: | +42 basis points |
| Yield to Maturity: | 4.040% |
| Price to Public: | 99.821% of the Aggregate Principal Amount |
| Interest Payment Dates: | March 2 and September 2, commencing September 2, 2026 |
| Gross Proceeds to Issuer: | $648,836,500 |
| Underwriting Discount: | 0.225% of the Aggregate Principal Amount |
| Net Proceeds to Issuer (before expenses): | $647,374,000 |
| Redemption Provisions: | |
| Optional Redemption: | At the option of the Issuer, from time to time, in whole or in part, as follows: (i) prior to February 2, 2031, at a redemption price equal to the greater of (1) (a) the sum of the present values of the remaining scheduled payments of principal and interest on the Notes to be redeemed discounted to the redemption date (assuming such Notes matured on February 2, 2031) on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the treasury rate plus 10 basis points less (b) interest accrued to the date of redemption, and (2) 100% of the principal amount of the Notes to be redeemed, plus, in either case, accrued and unpaid interest on the Notes to be redeemed to the redemption date and (ii) on or after February 2, 2031, at a redemption price equal to 100% of the principal amount of the Notes to be redeemed, plus accrued interest thereon to but excluding the date of redemption. |
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| Optional Tax Redemption: | In the event of certain tax law changes and other limited circumstances relating to tax matters, in whole but not in part, at a price equal to 100% of the principal amount of the Notes to be redeemed plus accrued interest thereon to but excluding the redemption date. |
| CUSIP: | 04636N AQ6 |
| ISIN: | US04636NAQ60 |
$600,000,000 4.300% Notes due 2033:
| Security Type: | Senior Notes |
| Aggregate Principal Amount: | $600,000,000 |
| Maturity Date: | March 2, 2033 |
| Coupon: | 4.300% |
| Benchmark Treasury: | 4.000% due January 31, 2033 |
| Benchmark Treasury Price and Yield: | 101-04, 3.813% |
| Spread to Benchmark Treasury: | +52 basis points |
| Yield to Maturity: | 4.333% |
| Price to Public: | 99.803% of the Aggregate Principal Amount |
| Interest Payment Dates: | March 2 and September 2, commencing September 2, 2026 |
| Gross Proceeds to Issuer: | $598,818,000 |
| Underwriting Discount: | 0.275% of the Aggregate Principal Amount |
| Net Proceeds to Issuer (before expenses): | $597,168,000 |
| Redemption Provisions: | |
| Optional Redemption: | At the option of the Issuer, from time to time, in whole or in part, as follows: (i) prior to January 2, 2033, at a redemption price equal to the greater of (1) (a) the sum of the present values of the remaining scheduled payments of principal and interest on the Notes to be redeemed discounted to the redemption date (assuming such Notes matured on January 2, 2033) on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the treasury rate plus 10 basis points less (b) interest accrued to the date of redemption, and (2) 100% of the principal amount of the Notes to be redeemed, plus, in either case, accrued and unpaid interest on the Notes to be redeemed to the redemption date and (ii) on or after January 2, 2033, at a redemption price equal to 100% of the principal amount of the Notes to be redeemed, plus accrued interest thereon to but excluding the date of redemption. |
| Optional Tax Redemption: | In the event of certain tax law changes and other limited circumstances relating to tax matters, in whole but not in part, at a price equal to 100% of the principal amount of the Notes to be redeemed plus accrued interest thereon to but excluding the redemption date. |
| CUSIP: | 04636N AR4 |
| ISIN: |
US04636NAR44 |
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$750,000,000 4.600% Notes due 2036:
| Security Type: | Senior Notes |
| Aggregate Principal Amount: | $750,000,000 |
| Maturity Date: | March 2, 2036 |
| Coupon: | 4.600% |
| Benchmark Treasury: | 4.125% due February 15, 2036 |
| Benchmark Treasury Price and Yield: | 100-19+, 4.050% |
| Spread to Benchmark Treasury: | +60 basis points |
| Yield to Maturity: | 4.650% |
| Price to Public: | 99.604% of the Aggregate Principal Amount |
| Interest Payment Dates: | March 2 and September 2, commencing September 2, 2026 |
| Gross Proceeds to Issuer: | $747,030,000 |
| Underwriting Discount: | 0.325% of the Aggregate Principal Amount |
| Net Proceeds to Issuer (before expenses): | $744,592,500 |
| Redemption Provisions: | |
| Optional Redemption: | At the option of the Issuer, from time to time, in whole or in part, as follows: (i) prior to December 2, 2035, at a redemption price equal to the greater of (1) (a) the sum of the present values of the remaining scheduled payments of principal and interest on the Notes to be redeemed discounted to the redemption date (assuming such Notes matured on December 2, 2035) on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the treasury rate plus 10 basis points less (b) interest accrued to the date of redemption, and (2) 100% of the principal amount of the Notes to be redeemed, plus, in either case, accrued and unpaid interest on the Notes to be redeemed to the redemption date and (ii) on or after December 2, 2035, at a redemption price equal to 100% of the principal amount of the Notes to be redeemed, plus accrued interest thereon to but excluding the date of redemption. |
| Optional Tax Redemption: | In the event of certain tax law changes and other limited circumstances relating to tax matters, in whole but not in part, at a price equal to 100% of the principal amount of the Notes to be redeemed plus accrued interest thereon to but excluding the redemption date. |
| CUSIP: | 04636N AS2 |
| ISIN: | US04636NAS27 |
| Joint Book-Running Managers: |
BofA Securities, Inc. Deutsche Bank Securities Inc. HSBC Securities (USA) Inc. Mizuho Securities USA LLC Santander US Capital Markets LLC
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Co-Managers:
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Barclays Capital Inc. BNP Paribas Securities Corp. Citigroup Global Markets Inc. Goldman Sachs & Co. LLC J.P. Morgan Securities LLC Morgan Stanley & Co. LLC SEB Securities, Inc. SG Americas Securities, LLC Independence Point Securities LLC R. Seelaus & Co., LLC |
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No PRIIPs or UK PRIIPs key information document (KID) has been prepared as the Notes are not available to retail in the EEA or the UK.
Note: A securities rating is not a recommendation to buy, sell or hold securities and may be subject to revision or withdrawal at any time.
The Issuer has filed a registration statement (including a prospectus supplement and accompanying prospectus) with the SEC for the offering to which this communication relates. Before you invest, you should read the prospectus in that registration statement, the preliminary prospectus supplement and other documents incorporated by reference therein that the issuer has filed with the SEC for more complete information about the issuer and this offering. You may get these documents for free by visiting EDGAR on the SEC Website at www.sec.gov. Alternatively, the issuer, any underwriter or any dealer participating in the offering will arrange to send you the prospectus if you request it from BofA Securities, Inc. by telephone at +1-800-294-1322; Deutsche Bank Securities Inc. toll-free at +1-800-503-4611; HSBC Securities (USA) Inc., by telephone at + 1 866-811-8049; or Mizuho Securities USA LLC, by telephone at +1 866-271-7403.
It is expected that delivery of the notes will be made against payment on or about the Settlement Date, which will be the third business day following the Trade Date of the notes (such settlement being referred to as “T+3”). Trades in the secondary market are required to settle in one business day, unless the parties to any such trade expressly agree otherwise. Accordingly, purchasers who wish to trade notes prior to the delivery of the notes hereunder may be required, by virtue of the fact that the notes will initially settle in T+3, to specify an alternate settlement arrangement at the time of any such trade to prevent a failed settlement. Purchasers of the notes who wish to trade the notes prior to their date of delivery hereunder should consult their advisors.
Any disclaimer or other notice that may appear below is not applicable to this communication and should be disregarded. Such disclaimer or notice was automatically generated as a result of this communication being sent by Bloomberg or another email system.
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