February 18, 2025

Britt Vitalone
Chief Financial Officer
McKesson Corporation
6555 State Hwy 161
Irving, TX 75039

        Re: McKesson Corporation
            Form 10-K for Fiscal Year Ended March 31, 2024
            File No. 001-13252
Dear Britt Vitalone:

       We have reviewed your filing and have the following comment.

       Please respond to this letter within ten business days by providing the
requested
information or advise us as soon as possible when you will respond. If you do
not believe a
comment applies to your facts and circumstances, please tell us why in your
response.

       After reviewing your response to this letter, we may have additional
comments.

Form 10-K for Fiscal Year Ended March 31, 2024
Management's Discussion and Analysis of Financial Condition and Results of
Operations
Financial Condition, Liquidity, and Capital Resources
Operating Activities, page 48

1.     Your disclosure here and in the Form 10-Q for the interim period ended
December 31,
       2024 appears to show how reported operating cash was derived for each
period as
       already presented in the statement of cash flows. Please note citing
items reported in
       the statement of cash flows may not provide a sufficient basis to
understand how cash
       was affected and changed by them. For example, you refer to changes in
accounts
       receivable, which represents uncollected revenue, and accounts payable,
which
       represents unpaid amounts to others. Operating cash decreased in the
current annual
       and noted interim period relative to the corresponding prior year
period, yet the cited
       lower amount of litigation payments in the current period suggests
operating cash
       should have increased. Also, you refer to noncash items and
accruals/charges that do
       not appear to change cash. Your analysis should be of the factors that
caused the
       reported amount of operating cash to vary from period to period.
Regarding analysis,
       refer to the introductory paragraph of Item 303(b) of Regulation S-K,
introductory
       paragraph of section IV.B and all of section B.1 of Release No. 33-8350
for guidance.
 February 18, 2025
Page 2

       Additionally, refer to section III.D of Release No. 33-6835 (501.04 of
the staff   s
       Codification of Financial Reporting) regarding quantification of factors
affecting
       operating cash flows, as well as results discussed elsewhere. Please
revise your
       disclosure as appropriate.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence
of action by the staff.

       Please contact Abe Friedman at 202-551-8298 or Doug Jones at
202-551-3309 if you
have questions regarding comments on the financial statements and related
matters.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of Trade &
Services