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SCHEDULE 13D/A 0001144204-08-009710 0001188834 XXXXXXXX LIVE 11 Common Stock, par value $0.01 per share 04/02/2025 false 0000944809 68375N103 OPKO HEALTH, INC. 4400 BISCAYNE BLVD. MIAMI FL 33137 Camielle Green (305) 575-4100 OPKO Health, Inc. 4400 Biscayne Boulevard Miami FL 33137 0001188834 N HSIAO JANE PH D PF OO N X1 35677284.00 0.00 35677284.00 0.00 35677284.00 N 4.5 IN (1) Includes (i) 27,999,880 shares of Common Stock held individually by Dr. Hsiao; (ii) 5,127,404 shares of Common Stock held by Hsu Gamma Investment, L.P. ("Hsu Gamma"), which is controlled by Dr. Hsiao as general partner; and (iii) options to acquire 2,550,000 shares of Common Stock, which are exercisable within 60 days. (2) Calculated based on (i) 793,051,553 shares outstanding as of April 3, 2025, as communicated by the Issuer to the Reporting Person; and (ii) options to acquire 2,550,000 shares of Common Stock, which are exercisable within 60 days. Y Hsu Gamma Investments, LP a AF OO N FL 5127404.00 0.00 5127404.00 0.00 5127404.00 N 0.7 PN (1) Calculated based on 793,051,553 shares outstanding as of April 3, 2025, as communicated by the Issuer to the Reporting Person. Common Stock, par value $0.01 per share OPKO HEALTH, INC. 4400 BISCAYNE BLVD. MIAMI FL 33137 This Amendment No. 11 (the "Amendment") amends and supplements the statement on Schedule 13D filed on February 14, 2008, as amended by Amendment No. 1 to the Schedule 13D filed on August 21, 2008, as amended by Amendment No. 2 to the Schedule 13D filed on October 1, 2009, as amended by Amendment No. 3 to the Schedule 13D filed on March 22, 2013, as amended by Amendment No. 4 to the Schedule 13D filed on September 16, 2013, as amended by Amendment No. 5 to the Schedule 13D filed on December 18, 2015, as amended by Amendment No. 6 to the Schedule 13D filed on November 20, 2018, as amended by Amendment No. 7 to the Schedule 13D filed on November 1, 2019, as amended by Amendment No. 8 to the Schedule 13D filed on March 20, 2020, as amended by Amendment No. 9 to the Schedule 13D filed on August 19, 2022, as amended by Amendment No. 10 to the Schedule 13D filed on January 24, 2024 (together, the "Original Schedule 13D"), by Jane Hsiao, Ph.D. ("Dr. Hsiao"), The Chiin Hsiung Hsiao Family Trust A, The Chiin Hsiung Hsiao Family Trust B, and Hsu Gamma Investment, L.P. ("Hsu Gamma"). This Amendment is filed with respect to the common stock, par value $0.01 per share ("Common Stock"), of OPKO Health, Inc., a Delaware corporation (the "Issuer") This Amendment is being filed solely as a result of a change in the Issuer's number of outstanding shares of Common Stock. Dr. Hsiao may be deemed to beneficially own 35,677,284 shares of Common Stock, which consist of (i) 5,127,404 shares of Common Stock held by Hsu Gamma, and (ii) 30,549,880 shares of Common Stock held individually. The 30,549,880 shares of Common Stock individually held by Dr. Hsiao include (i) 27,999,880 shares of Common Stock held individually; and (ii) options to purchase 2,550,000 shares of Common Stock, exercisable within 60 days of the date hereof. The 35,677,284 shares of Common Stock beneficially owned by Dr. Hsiao constitute approximately 4.48% of the Issuer's outstanding shares of Common Stock, based upon 793,051,553 shares outstanding as of April 3, 2025, as communicated by the Issuer to the Reporting Person. Dr. Hsiao has sole voting and dispositive power over 35,677,284 shares of Common Stock. Hsu Gamma beneficially owns 5,127,404 shares of Common Stock, which constitutes approximately 0.65% of the Issuer's outstanding shares of Common Stock, based upon 793,051,553 shares outstanding as of April 3, 2025, as communicated by the Issuer to the Reporting person. Dr. Hsiao is the general partner of Hsu Gamma and holds sole voting and dispositive power with respect to the 5,127,404 shares of Common Stock held by Hsu Gamma. Dr. Hsiao may be deemed to beneficially own 35,677,284 shares of Common Stock, which consist of (i) 5,127,404 shares of Common Stock held by Hsu Gamma, and (ii) 30,549,880 shares of Common Stock held individually. The 30,549,880 shares of Common Stock individually held by Dr. Hsiao include (i) 27,999,880 shares of Common Stock held individually; and (ii) options to purchase 2,550,000 shares of Common Stock, exercisable within 60 days of the date hereof. The 35,677,284 shares of Common Stock beneficially owned by Dr. Hsiao constitute approximately 4.48% of the Issuer's outstanding shares of Common Stock, based upon 793,051,553 shares outstanding as of April 3, 2025, as communicated by the Issuer to the Reporting Person. Dr. Hsiao has sole voting and dispositive power over 35,677,284 shares of Common Stock. Hsu Gamma beneficially owns 5,127,404 shares of Common Stock, which constitutes approximately 0.65% of the Issuer's outstanding shares of Common Stock, based upon 793,051,553 shares outstanding as of April 3, 2025, as communicated by the Issuer to the Reporting person. Dr. Hsiao is the general partner of Hsu Gamma and holds sole voting and dispositive power with respect to the 5,127,404 shares of Common Stock held by Hsu Gamma. In the last 60 days prior to the filing of this Amendment No. 11, Hsu Gamma and Dr. Hsiao have not effected any transactions in the shares of Common Stock. Except as described herein, no other person is known by any Reporting Person to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, any shares of the Issuer beneficially owned by them. On or about April 2, 2025, Dr. Hsiao ceased to beneficially own more than 5% of the Common Stock. HSIAO JANE PH D /s/ Jane H. Hsiao, Ph.D. Jane H. Hsiao, Ph.D., Individually 04/03/2025 Hsu Gamma Investments, LP /s/ Jane H. Hsiao, Ph.D. Jane H. Hsiao, Ph.D., General Partner 04/03/2025