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Exhibit 32.1

Certification Pursuant to 18 U.S.C. Sec. 1350

_______________________________________________

In connection with the filing by Service Properties Trust (the “Company”) of the Quarterly Report on Form 10-Q for the period ended September 30, 2025 (the “Report”), each of the undersigned hereby certifies, to the best of his knowledge:

1.The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2.The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

						/s/ Christopher J. Bilotto
						Christopher J. Bilotto
						President and Chief Executive Officer
						/s/ Brian E. Donley
						Brian E. Donley
						Chief Financial Officer and Treasurer
Date: November 5, 2025