Exhibit 21
Pharmaceutical Product Development, Inc. and Subsidiaries
The subsidiaries of Pharmaceutical Product Development, Inc., as of February 15, 2011, are as follows:
| Name of Subsidiary |
Jurisdiction of Incorporation | |||
| 1. |
Applied Bioscience International, LLC | Delaware | ||
| 2. |
PPD Global Central Labs, LLC | Kentucky | ||
| 3. |
PPD Aeronautics, LLC | North Carolina | ||
| 4. |
APBI Finance Corporation | Delaware | ||
| 5. |
PPD GP, LLC | Delaware | ||
| 6. |
PPD Holdings, LLC | Delaware | ||
| 7. |
PPD UK Holdings Ltd | United Kingdom | ||
| 8. |
PPD Development, LP | Texas | ||
| 9. |
ATP, LLC | North Carolina | ||
| 10. |
Pharmaco Investments, Inc. | Delaware | ||
| 11. |
PPD International Holdings, Inc. | Delaware | ||
| 12. |
PPD France SNC | France | ||
| 13. |
PPD Scandinavia AB | Sweden | ||
| 14. |
Pharmaceutical Product Development Spain SL | Spain | ||
| 15. |
PPD do Brasil-Suporte a Pesquisa Clinica Ltda. | Brazil | ||
| 16. |
PPD Argentina, S.A. | Argentina | ||
| 17. |
PPD International Holdings, Inc. y Compania Limitada | Chile | ||
| 18. |
Pharmaceutical Product Development South Africa (Pty) Ltd | South Africa | ||
| 19. |
PPD Canada, Ltd. | Canada | ||
| 20. |
PPD Australia Pty Ltd | Australia | ||
| 21. |
PPD International Holdings GmbH | Germany | ||
| 22. |
PPD Germany GmbH | Germany | ||
| 23. |
PPD Poland Sp. Z o.o. | Poland | ||
| 24. |
PPD Czech Republic s.r.o. | Czech Republic | ||
| 25. |
PPD Germany GmbH & Co KG | Germany | ||
| 26. |
PPD Hungary Research & Development Limited | Hungary | ||
| 27. |
PPD Italy S.r.l. | Italy | ||
| 28. |
PPD Mexico, S.A. de C.V. | Mexico | ||
| 29. |
PPD Development (Thailand) Co., Ltd | Thailand | ||
| 30. |
PPD Japan K.K. | Japan | ||
| 31. |
PPD Global, Ltd | United Kingdom | ||
| 32. |
Clinical Technology Centre (International) Ltd | United Kingdom | ||
| 33. |
Cambridge Applied Nutrition Toxicology & Biosciences Ltd | United Kingdom | ||
| 34. |
Clinical Science Research International Ltd | United Kingdom | ||
| 35. |
Leicester Clinical Research Centre Ltd | United Kingdom | ||
| 36. |
Chelmsford Clinical Trials Unit Ltd | United Kingdom | ||
| 37. |
Gabbay Ltd | United Kingdom | ||
| 38. |
Data Analysis & Research (DAR) Ltd | Scotland | ||
| 39. |
PPD Global Central Labs BVBA | Belgium | ||
| 40. |
PPD Development (S) Pte Limited | Singapore | ||
| 41. |
PPD Development (HK) Limited | Hong Kong | ||
| 42. |
PPD (Netherlands) BV | Netherlands | ||
| 43. |
PPD Pharmaceutical Development India Private Limited | India |
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| 44. |
River Ventures, LLC | North Carolina | ||
| 45. |
PPD Slovak Republic s.r.o. | Slovak Republic | ||
| 46. |
PPD Peru S.A.C. | Peru | ||
| 47. |
PPD Vaccines and Biologics, LLC | Pennsylvania | ||
| 48. |
PPD Pharmaceutical Development (Beijing) Co., Ltd | China | ||
| 49. |
Greenbird Limited | Cyprus | ||
| 50. |
PPD Development Ireland Ltd | Ireland | ||
| 51. |
Limited Liability Company PPD Development (Smolensk) | Russia | ||
| 52. |
PPD Global Central Labs (S) Pte. Ltd. | Singapore | ||
| 53. |
Limited Liability Company Contract Research Organization Innopharm – Ukraine | Ukraine | ||
| 54. |
PPD Dermatology, LLC | Delaware | ||
| 55. |
AbC.R.O., Inc. | Virginia | ||
| 56. |
PPD BULGARIA EOOD | Bulgaria | ||
| 57. |
BioDuro LLC | Delaware | ||
| 58. |
BioDuro (Mauritius) | Mauritius | ||
| 59. |
BIODURO (BAONUO) BEIJING TECHNOLOGY CO., LTD. | Beijing, China | ||
| 60. |
Excel Pharmastudies, Inc. | Cayman | ||
| 61. |
Excel Pharmastudies Inc. | Beijing, China | ||
| 62. |
EXCEL PHARMASTUDIES TAIZHOU BIOMETRICS, INC. | China | ||
| 63. |
EXCEL PHARMASTUDIES TAIZHOU VACCINE, INC. | China | ||
| 64. |
Excel Pharmastudies (US), Inc. | California | ||
| 65. |
PPD CT Investments LLP | United Kingdom | ||
| 66. |
PPD Romania SRL | Romania | ||
| 67. |
AbC.R.O. d.o.o. | Croatia | ||
| 68. |
AbC.R.O. Poland Sp. Z o.o. | Poland | ||
| 69. |
Limited Liability Company ABC.R.O. (ooo ABC.R.O.) | Russia | ||
| 70. |
X-Chem, Inc. | Delaware | ||
| 71. |
PPD Colombia S.A.S. | Colombia | ||
| 72. |
PPD (Guatemala), S.A. | Guatemala | ||
| 73. |
BioDuro Biologics Pte. Ltd. | Singapore |
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Subsidiaries 1, 2, 47 and 54 are wholly-owned subsidiaries of Pharmaceutical Product Development, Inc.
Subsidiaries 5 and 6 are wholly-owned subsidiaries of Subsidiary 1.
Subsidiary 8 is owned 99.9% by Subsidiary 6 and 0.1% by Subsidiary 5.
Subsidiaries 3, 4, 9, 10, 11, and 44 are wholly-owned subsidiaries of Subsidiary 8.
Subsidiaries 13, 18, 19, 20, 21, 27, 30 and 55 are wholly-owned subsidiaries of Subsidiary 11.
Subsidiary 12 is owned 99.999% by Subsidiary 11 and 0.01% by Subsidiary 1.
Subsidiary 14 is owned 99.231 % by Subsidiary 11 and 0.769% by Subsidiary 8.
Subsidiary 15 is owned 99.99% by Subsidiary 11 and 0.01% by Pharmaceutical Product Development, Inc.
Subsidiary 16 is owned 95% by Subsidiary 11 and 5% by Subsidiary 1.
Subsidiary 17 is owned 99% by Subsidiary 11 and 1% by Subsidiary 1.
Subsidiaries 22 and 23 are wholly-owned subsidiaries of Subsidiary 21.
Subsidiary 24 is owned 97.78% by Subsidiary 21 and 2.22% by Subsidiary 11.
Subsidiary 25 is a wholly- owned subsidiary of Subsidiary 21.
Subsidiary 26 is owned 96.67% by Subsidiary 21 and 3.33% by Subsidiary 11.
Subsidiary 28 is owned 99.99% by Subsidiary 11 and 0.01% by Subsidiary 8.
Subsidiary 29 is owned 99.99% by Subsidiary 11 and 1 share is held by each of Subsidiary 7 and Subsidiary 40.
Subsidiaries 31, 35, 36, 37, 38, 40, 42, 50, 52, 56, 57 and 60 are wholly-owned subsidiaries of Subsidiary 7.
Subsidiary 32 is owned 99% by Subsidiary 31 and 1% by Subsidiary 7.
Subsidiary 33 is owned 50% by Subsidiary 7 and 50% by Subsidiary 31.
Subsidiary 34 is a wholly-owned subsidiary of Subsidiary 31.
Subsidiary 39 is 99.9% owned by Subsidiary 7 and 0.1% by Subsidiary 31.
Subsidiary 41 is 50% owned by Subsidiary 40 and 50% by Subsidiary 1.
Subsidiary 43 is owned 99.99% by Subsidiary 7 and .01% by Subsidiary 31.
Subsidiary 45 is owned 85% by Subsidiary 7 and 15% by Subsidiary 31.
Subsidiary 46 is owned 99.99% by Subsidiary 11 and .01% by Subsidiary 1.
Subsidiary 48 is a wholly-owned subsidiary of Subsidiary 40.
Subsidiary 49 is owned 99.95% by Subsidiary 7 and 0.05% by Subsidiary 42.
Subsidiary 51 is a wholly-owned subsidiary of Subsidiary 49.
Subsidiary 53 is a wholly-owned subsidiary of Subsidiary 51.
Subsidiary 7 is 99.6% owned by Subsidiary 11 and 0.4% by Subsidiary 55.
Subsidiary 58 is a wholly-owned subsidiary of Subsidiary 57.
Subsidiary 59 is a wholly-owned subsidiary of Subsidiary 58.
Subsidiary 61 and 64 are wholly-owned subsidiaries of Subsidiary 60.
Subsidiary 62 is 50% owned by Subsidiary 61 and 50% by an unrelated third party.
Subsidiary 63 is 33.33% owned by Subsidiary 61, 16.67% by Subsidiary 62 and 50% by an unrelated third party.
Subsidiary 65 is 80% owned by Subsidiary 4 and 20% by Subsidiary 11.
Subsidiary 66 is 99.3% owned by Subsidiary 55 and 0.7% by Subsidiary 56.
Subsidiaries 67 and 68 are wholly-owned subsidiaries of Subsidiary 55.
Subsidiary 69 is 75% owned by Subsidiary 56 and 25% by Subsidiary 55.
Subsidiary 70 is owned 60% by Pharmaceutical Product Development, Inc. and 40% owned by an unrelated third party.
Subsidiary 71 is a wholly-owned subsidiary of Subsidiary 7.
Subsidiary 72 is 99% owned by Subsidiary 11 and 1% by Subsidiary 1.
Subsidiary 73 is 75% owned by Subsidiary 40 and 25% by an unrelated third party.
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