| Name | Jurisdiction | |||||||
| Avadel Pharmaceuticals plc (the Registrant): | Ireland | |||||||
1) Avadel US Holdings, Inc. (f/k/a Flamel US Holdings, Inc.) | United States (Delaware) | |||||||
| A. Avadel Management, LLC | United States (Delaware) | |||||||
| B. Avadel CNS Pharmaceuticals, LLC | United States (Delaware) | |||||||
2) Flamel Ireland Ltd. (d/b/a Avadel Ireland) | Ireland | |||||||
| 3) Avadel Investment Company, Ltd. | Cayman Islands | |||||||
| 4) Avadel France Holding SAS | France | |||||||
| A. Avadel Research SAS | France | |||||||
| 5) Avadel Finance Ireland Designated Activity Company | Ireland | |||||||
| A. Avadel Finance Cayman Ltd. | Cayman Islands | |||||||