<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0609</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-04-02</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001829802</issuerCik>
        <issuerName>Sensei Biotherapeutics, Inc.</issuerName>
        <issuerTradingSymbol>SNSE</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001273087</rptOwnerCik>
            <rptOwnerName>MILLENNIUM MANAGEMENT LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>399 PARK AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001783647</rptOwnerCik>
            <rptOwnerName>ICS OPPORTUNITIES II LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>C/O MILLENNIUM MANAGEMENT LLC</rptOwnerStreet1>
            <rptOwnerStreet2>399 PARK AVENUE</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
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            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
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            <rptOwnerName>MILLENNIUM GROUP MANAGEMENT LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
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            <rptOwnerStreet1>399 PARK AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
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            <isOfficer>0</isOfficer>
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            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001017456</rptOwnerCik>
            <rptOwnerName>ENGLANDER ISRAEL A</rptOwnerName>
        </reportingOwnerId>
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            <rptOwnerStreet1>C/O MILLENNIUM MANAGEMENT LLC</rptOwnerStreet1>
            <rptOwnerStreet2>399 PARK AVENUE</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
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            <isOfficer>0</isOfficer>
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            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

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                    <value>See Footnote</value>
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            <transactionAmounts>
                <transactionShares>
                    <value>300</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>32.2467</value>
                    <footnoteId id="F18"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>133986</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2026-04-07</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness></transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>1108</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>33.3800</value>
                    <footnoteId id="F19"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>133986</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Represents volume-weighted average price (&quot;VWAP&quot;) of purchases of 26 shares of common stock (&quot;Common Stock&quot;), par value $0.0001 per share, of Sensei Biotherapeutics, Inc. (the &quot;Company&quot;) on April 2, 2026 at prices ranging from $32.90 to $33.62. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting persons will provide full information regarding the number of shares purchased or sold by the reporting person at each separate price within each range represented by a VWAP disclosed herein.</footnote>
        <footnote id="F2">In each case, the number of shares of the Company's Common Stock disclosed in column 5 is the number of shares of the Company's Common Stock beneficially owned by Millennium Management LLC at the conclusion of the transactions on the date disclosed in the corresponding entry in column 2.</footnote>
        <footnote id="F3">The transactions in the Company's Common Stock reported herein were made by ICS Opportunities II LLC or other trading entities, in each case subject to voting control and investment discretion by Millennium Management LLC, Millennium Group Management LLC (the managing member of Millennium Management LLC) and Israel A. Englander (the sole voting trustee of the managing member of Millennium Group Management LLC). Each reporting person disclaims beneficial ownership of the shares of the Company's Common Stock disclosed herein except to the extent of such reporting person's pecuniary interest therein, if any.</footnote>
        <footnote id="F4">Represents VWAP of purchases of 1,276 shares of the Company's Common Stock on April 2, 2026 at prices ranging from $33.97 to $34.90.</footnote>
        <footnote id="F5">Represents VWAP of purchases of 701 shares of the Company's Common Stock on April 2, 2026 at prices ranging from $35.4481 to $35.91.</footnote>
        <footnote id="F6">Represents VWAP of sales of 3,099 shares of the Company's Common Stock on April 2, 2026 at prices ranging from $30.1332 to $31.1212.</footnote>
        <footnote id="F7">Represents VWAP of sales of 1,265 shares of the Company's Common Stock on April 2, 2026 at prices ranging from $31.21 to $32.15.</footnote>
        <footnote id="F8">Represents VWAP of sales of 1,794 shares of the Company's Common Stock on April 2, 2026 at prices ranging from $32.22 to $33.1251.</footnote>
        <footnote id="F9">Represents VWAP of sales of 374 shares of the Company's Common Stock on April 2, 2026 at prices ranging from $33.23 to $33.45.</footnote>
        <footnote id="F10">Represents VWAP of sales of 1,134 shares of the Company's Common Stock on April 2, 2026 at prices ranging from $34.40 to $35.25.</footnote>
        <footnote id="F11">Represents purchases of 1,104 shares of the Company's Common Stock on April 6, 2026 at $31.02 per share.</footnote>
        <footnote id="F12">Represents VWAP of sales of 1,214 shares of the Company's Common Stock on April 6, 2026 at prices ranging from $30.64 to $31.345.</footnote>
        <footnote id="F13">Represents VWAP of sales of 45 shares of the Company's Common Stock on April 6, 2026 at prices ranging from $31.80 to $32.17.</footnote>
        <footnote id="F14">Represents VWAP of purchases of 1,108 shares of the Company's Common Stock on April 7, 2026 at $33.38 per share.</footnote>
        <footnote id="F15">Represents VWAP of sales of 2,115 shares of the Company's Common Stock on April 7, 2026 at prices ranging from $28.5071 to $29.3167.</footnote>
        <footnote id="F16">Represents VWAP of sales of 205 shares of the Company's Common Stock on April 7, 2026 at prices ranging from $29.695 to $30.50.</footnote>
        <footnote id="F17">Represents VWAP of sales of 4,423 shares of the Company's Common Stock on April 7, 2026 at prices ranging from $30.9852 to $31.813.</footnote>
        <footnote id="F18">Represents VWAP of sales of 300 shares of the Company's Common Stock on April 7, 2026 at prices ranging from $32.0625 to $32.615.</footnote>
        <footnote id="F19">Represents sales of 1,108 shares of the Company's Common Stock on April 7, 2026 at $33.38 per share.</footnote>
    </footnotes>

    <remarks>Assuming, without conceding, the application of Section 16(b) of the Securities Exchange Act of 1934, the reporting persons have disgorged to the Company all amounts that could be deemed profit realized by them from the transactions in the Company's Common Stock reported on this Form 4 and the other two statements on Form 4 filed by Millennium Management LLC on the same date.</remarks>

    <ownerSignature>
        <signatureName>MILLENNIUM MANAGEMENT LLC: By: /s/ Gil Raviv, Global General Counsel</signatureName>
        <signatureDate>2026-05-14</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>ICS OPPORTUNITIES II LLC, By: Millennium Management LLC, its Investment Manager: By: /s/ Gil Raviv, Global General Counsel</signatureName>
        <signatureDate>2026-05-14</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>MILLENNIUM GROUP MANAGEMENT LLC: By: /s/ Gil Raviv, Global General Counsel</signatureName>
        <signatureDate>2026-05-14</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Israel A. Englander</signatureName>
        <signatureDate>2026-05-14</signatureDate>
    </ownerSignature>
</ownershipDocument>