Exhibit 32.1
CERTIFICATION PURSUANT TO 
18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO 
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
I, Jennifer K. Simpson, hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:
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			 (1)  | 
			
			 the Annual Report on Form 10-K of Panbela Therapeutics, Inc for the year ended December 31, 2022 (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and  | 
		
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			 (2)  | 
			
			 the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of Panbela Therapeutics, Inc  | 
		
Dated: March 16, 2023
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			 /s/ Jennifer K. Simpson  | 
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			 Jennifer K. Simpson  | 
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			 President and Chief Executive Officer  | 
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			 (Principal Executive Officer)  |