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Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

I, Leslie C.G. Campbell, and I, Douglas Krulik, each certify to the best of our knowledge, based upon a review of the Annual Report on Form 10-K for the year ended March 31, 2025 (the “Report”) of PetMed Express, Inc. (the “Registrant”), that:

(1)the Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

(2)the information contained in the Report, fairly presents, in all material respects, the financial condition and results of operations of the Registrant.

			Date: October 14, 2025
			By:			/s/ Leslie C.G. Campbell
			Leslie C.G. Campbell
			Interim Chief Executive Officer and President (principal executive officer)
			By:			/s/ Douglas Krulik
			Douglas Krulik
			Chief Accounting Officer and Interim Principal Financial Officer and Treasurer (principal financial and accounting officer)