Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of Seattle Genetics, Inc. of our report dated February 7, 2019 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in Seattle Genetics, Inc.’s Annual Report on Form 10-K for the year ended December 31, 2018.

/s/ PricewaterhouseCoopers LLP

Seattle, Washington

June 27, 2019