Exhibit 10.1    [**] Certain information has been omitted from this exhibit because it is both (i) not material and  (ii) would be competitively harmful if publicly disclosed.    SEVENTH AMENDMENT TO LOAN AND SECURITY AGREEMENT  This Seventh Amendment (this “Amendment”) to the Loan Agreement (as defined  herein) is entered into as of March 27, 2025 (the “Seventh Amendment Date”), by and among  OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115  South Union Street, Suite 300, Alexandria, VA 22314 (“Oxford”), as collateral agent (in such  capacity, “Collateral Agent”), the Lenders party hereto from time to time including OXFORD  FINANCE CREDIT FUND II, LP, by its manager Oxford Finance Advisors, LLC (“Credit  Fund II”), OXFORD FINANCE CREDIT FUND III, LP, by its manager Oxford Finance  Advisors, LLC (“Credit Fund III”), OXFORD FINANCE FUNDING IX, LLC (“Funding  IX”), OXFORD FINANCE FUNDING XIII, LLC (“Funding XIII”), and OXFORD FINANCE  FUNDING 2023-1, LLC (“Funding 2023-1”; together with Credit Fund II, Credit Fund III,  Funding IX, and Funding XIII, each a “Lender” and collectively, the “Lenders”), LEXICON  PHARMACEUTICALS, INC. (“Parent”) and LEXICON PHARMACEUTICALS (NEW  JERSEY), INC. (“Lex-NJ”), each a Delaware corporation with offices located at 2445  Technology Forest Blvd., 11th Floor, The Woodlands, TX 77381 (Parent and Lex-NJ,  individually and collectively, jointly and severally, “Borrower”).    WHEREAS, Collateral Agent, Borrower and Lenders party thereto from time to time  have entered into that certain Loan and Security Agreement, dated as of March 17, 2022 (as  amended, supplemented or otherwise modified from time to time, the “Loan Agreement”)  pursuant to which Lenders have provided to Borrower certain loans in accordance with the terms  and conditions thereof;   WHEREAS, on or about the date hereof, Parent is entering or has entered into that certain  Exclusive License Agreement with NOVO NORDISK A/S., a corporation organized and  existing under the laws of Denmark (“Novo Nordisk”) (strictly in the form attached hereto as  Exhibit A and without any amendments thereto, the “Novo License Agreement”);  WHEREAS, Borrower has requested that Collateral Agent and Lenders consent to entry  by Borrower into the Novo License Agreement and the consummation by Borrower of the  transactions set forth therein, to the extent that such consent may be required pursuant to Section  7.1 or Section 7.5 of the Loan Agreement;   WHEREAS, Collateral Agent and Lenders have agreed to provide such consent, but only  to the extent set forth herein, in accordance with the terms and subject to the conditions set forth  herein, and in reliance upon the representations and warranties set forth herein; and  WHEREAS, Borrower, Lenders and Collateral Agent desire to amend certain provisions  of the Loan Agreement as provided herein and subject to the terms and conditions set forth  herein.  NOW, THEREFORE, in consideration of the promises, covenants and agreements  contained herein, and other good and valuable consideration, the receipt and adequacy of which  are hereby acknowledged, Borrower, Lenders and Collateral Agent hereby agree as follows:    2  1. Capitalized terms used herein but not otherwise defined shall have the respective  meanings given to them in the Loan Agreement.    2. Subject to the terms and conditions hereof, Collateral Agent and Lenders hereby consent  to Borrower’s entry into the Novo License Agreement and the consummation of the  transactions set forth therein, to the extent that such consent is required pursuant to  Section 7.1 or Section 7.5 of the Loan Agreement.    3. Section 2.2(b) of the Loan Agreement is hereby amended and restated in its entirety as  follows:    (b) Repayment. Borrower shall make monthly payments of interest only commencing  on the first (1st) Payment Date following the Funding Date of each Term Loan, and  continuing on the Payment Date of each successive month thereafter through and  including the Payment Date immediately preceding the Amortization Date. Commencing  on the Amortization Date, and continuing on the Payment Date of each month thereafter,  Borrower shall make consecutive equal monthly payments of principal (in accordance  with the applicable repayment schedule described in clause (3) below), together with  applicable interest, in arrears, to each Lender, as calculated by Collateral Agent (which  calculations shall be deemed correct absent manifest error) based upon: (1) the amount of  such Lender’s Term Loan, (2) the effective rate of interest, as determined pursuant to  Section 2.3(a), and (3) a repayment amortization schedule equal to (A) twelve (12)  months, if the [**] Event does not occur, or (B) twenty-three (23) months, if the [**]  Event occurs, in the amounts set forth in Schedule 2.2(b) hereto. All unpaid principal and  accrued and unpaid interest with respect to each Term Loan is due and payable in full on  the Maturity Date. Each Term Loan may only be prepaid in accordance with Sections  2.2(c) and 2.2(d).    4. Section 2.2(d) of the Loan Agreement is hereby amended and restated in its entirety as  follows:    (d) Permitted and Certain Required Prepayment of Term Loans.  (i) Borrower shall have the option to prepay all, but not less than all, of the Term  Loans advanced by the Lenders under this Agreement, provided Borrower (i) provides  written notice to Collateral Agent of its election to prepay the Term Loans at least ten  (10) Business Days prior to such prepayment, and (ii) pays to the Lenders on the date of  such prepayment, payable to each Lender in accordance with its respective Pro Rata  Share, an amount equal to the sum of (A) all outstanding principal of the Term Loans  plus accrued and unpaid interest thereon through the prepayment date, (B) the Final  Payment, (C) the applicable Prepayment Fee, plus (D) all other Obligations that are due  and payable, including Lenders’ Expenses that are due and payable hereunder and  interest at the Default Rate with respect to any past due amounts.  (ii) Notwithstanding anything herein to the contrary, Borrower shall on or prior to  the Required Prepayment Date prepay part of Term Loans advanced by the Lenders    3  under this Agreement to each Lender in accordance with its respective Pro Rata Share, by  paying an amount of (A) Forty Five Million Dollars ($45,000,000) which shall be applied  to: (i) prepayment of Forty Two Million Fifty Six Thousand Seventy Four Dollars and  Seventy Seven Cents ($42,056,074.77) of the principal amount of Term Loans  outstanding and (ii) payment of the applicable Final Payment with respect to the  aforementioned principal amount (calculated as Two Million Nine Hundred Forty Three  Thousand Nine Hundred Twenty Five Dollars and Twenty Three Cents ($2,943,925.23)),  (B) all accrued and unpaid interest on such principal amount through the date of the  prepayment, and (C) all other Obligations that are then due and payable, including  Lenders’ Expenses and interest at the Default Rate with respect to any past due amounts;  provided, however, the Prepayment Fee with respect to the portion of the Term Loans  prepaid pursuant to this Section 2.2(d)(ii) shall be deemed waived upon their timely  prepayment in the full amount set forth herein.  For the purposes of clarity, such partial  prepayment shall be applied pro-rata to all outstanding amounts under each Term Loan,  and shall be applied pro-rata within each Term Loan tranche to reduce amortization  payments under Section 2.2(b) on a pro-rata basis.    (iii) Notwithstanding anything herein to the contrary, if the [**] Event does not  occur, Borrower shall on or prior to [**], prepay part of the Term Loans advanced by the  Lenders under this Agreement to each Lender in accordance with its respective Pro Rata  Share, by paying an amount of (A) Three Million Dollars ($3,000,000) which shall be  applied to: (i) prepayment of Two Million Eight Hundred Three Thousand Seven  Hundred Thirty Eight Dollars and Thirty Two Cents ($2,803,738.32) of the principal  amount of Term Loans outstanding and (ii) payment of the applicable Final Payment with  respect to the aforementioned principal amount (calculated as One Hundred Ninety Six  Thousand Two Hundred Sixty One Dollars and Sixty Eight Cents ($196,261.68)), (B) all  accrued and unpaid interest on such principal amount through the date of the prepayment,  and (C) all other Obligations that are then due and payable, including Lenders’ Expenses  and interest at the Default Rate with respect to any past due amounts; provided, however,  that if the [**] Event does not occur and Borrower receives [**], then, within three (3)  Business Days following the receipt of such [**], Borrower shall additionally prepay part  of the Term Loans advanced by the Lenders under this Agreement to each Lender in  accordance with its respective Pro Rata Share, by paying an amount of (A) Five Million  Dollars ($5,000,000) which shall be applied to: (i) prepayment of Four Million Six  Hundred Seventy Two Thousand Eight Hundred Ninety Seven Dollars and Twenty Cents  ($4,672,897.20) of the principal amount of Term Loans outstanding and (ii) payment of  the applicable Final Payment with respect to the aforementioned principal amount  (calculated as Three Hundred Twenty Seven Thousand One Hundred Two Dollars and  Eighty Cents ($327,102.80)), (B) all accrued and unpaid interest on such principal  amount through the date of the prepayment, and (C) all other Obligations that are then  due and payable, including Lenders’ Expenses and interest at the Default Rate with  respect to any past due amounts; provided further that the Prepayment Fee with respect to  the portion of the Term Loans prepaid pursuant to this Section 2.2(d)(iii) shall be deemed  waived upon their timely prepayment in the full amount set forth herein. For the purposes  of clarity, such partial prepayments shall be applied pro-rata to all outstanding amounts    4  under each Term Loan, and shall be applied pro-rata within each Term Loan tranche to  reduce amortization payments under Section 2.2(b) on a pro-rata basis.    5. Section 6.2(a)(v) of the Loan Agreement is hereby amended and restated in its entirety as  follows:    (v)  within ten (10) Business Days following the end of each calendar month, a  Summary Cash Report substantially in the form attached hereto as Exhibit E (the  “Summary Cash Report”), certified by a Responsible Officer and attaching bank  statements for each Collateral Account subject to a Control Agreement in favor of  Collateral Agent for the most recently ended calendar month.    6. Section 6.10 of the Loan Agreement is hereby amended and restated in its entirety as  follows:    6.10 Financial Covenants.    (a) From and after the Seventh Amendment Date, tested monthly, Borrower shall  maintain at all times minimum unrestricted cash, cash equivalents, short-term  investments, and restricted cash in Collateral Accounts subject to Control Agreements  in favor of Collateral Agent, inclusive of the Required Minimum Amount to be  maintained in the Blocked Account, in an amount equal to not less than the greater of  (i) fifty percent (50.00%) of the outstanding principal amount of all Term Loans  advanced to Borrower and (ii) the Required Minimum Amount. Testing shall be  determined by reference to the most recent Summary Cash Report in the form  attached hereto as Exhibit E and related bank statements delivered to Collateral  Agent.    (b) By no later than fifteen (15) Business Days after the Seventh Amendment Date,  Borrower shall establish the Blocked Account and transfer the Required Minimum  Amount into the Blocked Account.    7. Section 8.1 of the Loan Agreement is hereby amended and restated in its entirety as  follows:    8.1 Payment Default. Borrower fails to (a) make any payment of principal or interest  on any Credit Extension on its due date, (b) comply with its obligations under Section  2.2(d)(ii) or Section 2.2(d)(iii) or (c) pay any other Obligations within three (3) Business  Days after such Obligations are due and payable (which three (3) Business Day grace  period shall not apply to payments due on the Maturity Date or the date of acceleration  pursuant to Section 9.1 (a) hereof). During the cure period, the failure to cure the  payment default is not an Event of Default (but no Credit Extension will be made during  the cure period);    8. Section 13.1 of the Loan Agreement is hereby amended by adding the following  definition thereto in alphabetical order:  
 
 
  5    “[**] Event” is the receipt by Borrower, on or after the Seventh Amendment Date and on  or prior to [**], of unrestricted net cash proceeds of not less than [**] from [**], provided  such payment shall be in addition to and not under any payments received by Borrower  pursuant to the Novo License Agreement.    “Blocked Account” is a Collateral Account of Borrower that is subject to a blocked  account control agreement in favor of Collateral Agent, in such form and substance as are  satisfactory to Collateral Agent and from which account no withdrawals may be made  without Collateral Agent’s consent (which consent Collateral Agent may withhold in its  sole discretion) with the exception of withdrawals of interest income earned by the  balance maintained in the blocked account.    “Novo License Agreement” is defined in the Seventh Amendment.    “Required Minimum Amount” is Twenty Nine Million Dollars ($29,000,000.00).    “Required Prepayment Date” is the earlier of (i) the date that is three (3) Business Days  after the receipt by Borrower of the upfront fee set forth in Section 7.1 of the Novo  License Agreement and (ii) the date that is 18 days immediately after the Effective Date  (as defined in the Novo License Agreement), which in either case may be no later than  April 18, 2025.    “Seventh Amendment” is that certain Seventh Amendment to this Agreement entered  into by and among Lenders, Collateral Agent and Borrower on March 27, 2025.    “Seventh Amendment Date” is defined in the Seventh Amendment.    9. Section 13.1 of the Loan Agreement is hereby further amended by amending and  restating the following definitions therein as follows:    “Amortization Date” is May 1, 2027; provided that, if the [**] Event does not occur,  “Amortization Date” shall mean December 1, 2026.    “Maturity Date” is March 1, 2029; provided that, if the [**] Event does not occur,  “Maturity Date” shall mean November 1, 2027.    “Final Payment” is a payment (in addition to and not a substitution for the regular  monthly payments of principal plus accrued interest) due on the earliest to occur of (a)  the Maturity Date, or (b) the acceleration of any Term Loan, or (c) the prepayment of a  Term Loan pursuant to Section 2.2(c) or (d), equal to the original principal amount of  such Term Loan multiplied by the Final Payment Percentage, payable to Lenders in  accordance with their respective Pro Rata Shares. For the avoidance of doubt, the  calculation of any Final Payment shall not include the principal amount prepaid in  accordance with Section 2.2(d)(ii) and Section 2.2(d)(iii) if a Final Payment based on  such principal amount was made at the time of such prepayment.    6    10. Schedule 2.2(b) to the Loan Agreement is hereby amended and restated in its entirety as  set forth on Schedule 2.2(b) attached hereto.    11. Exhibit C to the Loan Agreement is hereby amended and restated as set forth on Exhibit  C hereto.    12. Exhibit E to the Loan Agreement is hereby amended and restated as set forth on Exhibit  E hereto.    13. Limitation of Amendment.    e. The consents and the amendments set forth above are effective for the purposes  set forth herein and shall be limited precisely as written and shall not be deemed  to (a) be a consent to any amendment, waiver or modification of any other term or  condition of any Loan Document, or (b) otherwise prejudice any right or remedy  which Lenders may now have or may have in the future under or in connection  with any Loan Document.    f. This Amendment shall be construed in connection with and as part of the Loan  Documents and all terms, conditions, representations, warranties, covenants and  agreements set forth in the Loan Documents, except as herein amended, are  hereby ratified and confirmed and shall remain in full force and effect.    14. To induce Collateral Agent and Lenders to enter into this Amendment, Borrower hereby  represents and warrants to Collateral Agent and Lenders as follows:     a. Immediately after giving effect to this Amendment, (a) the representations and  warranties contained in the Loan Documents are true, accurate and complete in all  material respects as of the date hereof (except to the extent such representations and  warranties relate to an earlier date, in which case they are true and correct in all  material respects as of such date), and (b) no Event of Default has occurred and is  continuing;    b. Borrower has the power and due authority to execute and deliver this Amendment  and to perform its obligations under the Loan Agreement, as amended by this  Amendment;     c. The organizational documents of Borrower delivered to Collateral Agent on the  Effective Date and subsequently delivered to Collateral Agent, remain true, accurate  and complete and have not been amended, supplemented or restated and are and  continue to be in full force and effect;     d. The execution and delivery by Borrower of this Amendment and the performance by  Borrower of its obligations under the Loan Agreement, as amended by this  Amendment, have been duly authorized;    7    e. The execution and delivery by Borrower of this Amendment and the performance by  Borrower of its obligations under the Loan Agreement, as amended by this  Amendment, do not and will not contravene (i) any material law or regulation binding  on or affecting Borrower, (ii) any material contractual restriction with a Person  binding on Borrower, (iii) any material order, judgment or decree of any court or  other governmental or public body or authority, or subdivision thereof, binding on  Borrower, or (iv) the organizational documents of Borrower;     f. The execution and delivery by Borrower of this Amendment and the performance by  Borrower of its obligations under the Loan Agreement, as amended by this  Amendment, do not require any order, consent, approval, license, authorization or  validation of, or filing, recording or registration with, or exemption by any  governmental or public body or authority, or subdivision thereof, binding on  Borrower, except as already has been obtained or made; and     g. This Amendment has been duly executed and delivered by Borrower and is the  binding obligation of Borrower, enforceable against Borrower in accordance with its  terms, except as such enforceability may be limited by bankruptcy, insolvency,  reorganization, liquidation, moratorium or other similar laws of general application  and equitable principles relating to or affecting creditors’ rights.     15. Except as expressly set forth herein, the Loan Agreement shall continue in full force and  effect without alteration or amendment.  This Amendment and the Loan Documents  represent the entire agreement about this subject matter and supersede prior negotiations  or agreements.    16. The Borrower hereby remises, releases, acquits, satisfies and forever discharges the  Lenders and Collateral Agent, their agents, employees, officers, directors, predecessors,  attorneys and all others acting or purporting to act on behalf of or at the direction of the  Lenders and Collateral Agent (“Releasees”), of and from any and all manner of actions,  causes of action, suit, debts, accounts, covenants, contracts, controversies, agreements,  variances, damages, judgments, claims and demands whatsoever, in law or in equity,  which any of such parties ever had, now has or, to the extent arising from or in  connection with any act, omission or state of facts taken or existing on or prior to the date  hereof, may have after the date hereof against the Releasees, for, upon or by reason of  any matter, cause or thing whatsoever relating to or arising out of the Loan Agreement or  the other Loan Documents on or prior to the date hereof through the date hereof.  Without  limiting the generality of the foregoing, the Borrower waives and affirmatively agrees not  to allege or otherwise pursue any defenses, affirmative defenses, counterclaims, claims,  causes of action, setoffs or other rights they do, shall or may have as of the date hereof,  including the rights to contest: (a) the right of Collateral Agent and each Lender to  exercise its rights and remedies described in the Loan Documents; (b) any provision of  this Amendment or the Loan Documents; or (c) any conduct of the Lenders or other  Releasees relating to or arising out of the Loan Agreement or the other Loan Documents  on or prior to the date hereof.    8    17. This Amendment shall be deemed effective as of the Seventh Amendment Date upon (a)  the due execution and delivery to Collateral Agent of this Amendment by each party  hereto, (b) Collateral Agent’s receipt of the fully executed Novo License Agreement and  (c) payment by Borrower of all Lenders’ Expenses incurred through the date hereof,  which may be debited (or ACH’d) from any of Borrower’s accounts.    18. This Amendment may be executed in any number of counterparts, each of which shall be  deemed an original, and all of which, taken together, shall constitute one and the same  instrument.    19. This Amendment and the rights and obligations of the parties hereto shall be governed by  and construed in accordance with the laws of the State of New York.      [Balance of Page Intentionally Left Blank]  
 
 
    IN WITNESS WHEREOF, the parties hereto have caused this Seventh Amendment to  the Loan Agreement to be executed as of the date first set forth above.  BORROWER:        LEXICON PHARMACEUTICALS,  INC.             By     Name:     Title:           LEXICON PHARMACEUTICALS  (NEW  JERSEY), INC.      By   Name:   Title:         COLLATERAL AGENT:        OXFORD FINANCE LLC            By     Name:     Title:         LENDERS:      OXFORD FINANCE FUNDING I, LLC  OXFORD FINANCE FUNDING IX, LLC  OXFORD FINANCE FUNDING XIII, LLC  OXFORD FINANCE FUNDING 2023-1, LLC, as Lender  By: Oxford Finance LLC, as its Servicer      By   Name:   Title:                         OXFORD FINANCE CREDIT FUNDING TRUST II By:  Oxford Credit Fund II LP, as its Servicer  By: Oxford Finance Advisors, LLC, as its Manager      By   Name:   Title:         OXFORD FINANCE CREDIT FUND III LP  By: Oxford Finance Credit Fund III LP, as its Collateral  Manager  By: Oxford Finance Advisors, LLC, as its Manager      By   Name:   Title:       OXFORD FINANCE CREDIT FUND III 2024-A LP, as  Lender  By: Oxford Finance Advisors, LLC, as its Servicer      By   Name:   Title:       Exhibit A    Novo License Agreement    [**]        Exhibit C      EXHIBIT C    Compliance Certificate    TO: OXFORD FINANCE LLC, as Collateral Agent  and Lender OXFORD FINANCE FUNDING I,  LLC, as Lender   OXFORD FINANCE FUNDING IX, LLC, as  Lender   OXFORD FINANCE FUNDING XIII, LLC, as  Lender   OXFORD FINANCE FUNDING 2023-1,  LLC, as Lender   OXFORD FINANCE CREDIT FUNDING  TRUST II, as Lender   OXFORD FINANCE CREDIT FUND III LP,  as Lender   OXFORD FINANCE CREDIT FUND III  2024-A LP, as Lender    FROM: LEXICON PHARMACEUTICALS, INC.,  for itself and on behalf of each Borrower      The undersigned authorized officer (“Officer”) of LEXICON PHARMACEUTICALS, INC. (for itself and on behalf  of each Borrower party to the Loan Agreement (as defined below), “Borrower”), hereby certifies that in accordance  with the terms and conditions of the Loan and Security Agreement by and among Borrower, Collateral Agent, and the  Lenders from time to time party thereto (the “Loan Agreement;” capitalized terms used but not otherwise defined  herein shall have the meanings given them in the Loan Agreement),  (a) Borrower is in complete compliance for the period ending _______________ with all required  covenants except as noted below;  (b) There are no Events of Default, except as noted below;  (c) Except as noted below, all representations and warranties of Borrower stated in the Loan Documents  are true and correct in all material respects on this date and for the period described in (a), above; provided, however,  that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified  or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly  referring to a specific date shall be true, accurate and complete in all material respects as of such date.  (d) Borrower, and each of Borrower’s Subsidiaries, has timely filed all required tax returns and reports,  Borrower, and each of Borrower’s Subsidiaries, has timely paid all foreign, federal, state, and local taxes, assessments,  deposits and contributions owed by Borrower, or Subsidiary, except as otherwise permitted pursuant to the terms of  Section 5.8 of the Loan Agreement;  (e) No Liens have been levied or claims made against Borrower or any of its Subsidiaries relating to  unpaid employee payroll or benefits of which Borrower has not previously provided written notification to Collateral  Agent and the Lenders.  
 
 
    Attached are the required documents, if any, supporting our certification(s).  The Officer, on behalf of Borrower,  further certifies that the attached financial statements are prepared in accordance with Generally Accepted Accounting  Principles (GAAP) and are consistently applied from one period to the next except as explained in an accompanying  letter or footnotes and except, in the case of unaudited financial statements, for the absence of footnotes and subject  to year-end audit adjustments as to the interim financial statements.    Please indicate compliance status since the last Compliance Certificate by circling Yes, No, or N/A under  “Complies” column.    Reporting Covenant Requirement Actual Complies  1) Financial statements Quarterly within 45 days  Yes No N/A  2)  Annual (CPA Audited)  statements Within 90 days after FYE  Yes No N/A  3)  Annual Financial  Projections/Budget (prepared on  a monthly basis)  Annually (within 45 days of FYE),  and when revised  Yes No N/A  4) A/R & A/P agings If applicable  Yes No N/A  5) 8-K, 10-K and 10-Q Filings If applicable, within 5 days of  filing  Yes No N/A  6) Compliance Certificate Quarterly within 45 days  Yes No N/A  7) Summary Cash Report Monthly within 10 Business Days  Yes No  N/A  8) IP Report When required  Yes No N/A  9)  Total amount of Borrower’s cash  and cash equivalents at the last  day of the measurement period   $________ Yes No N/A  10)  Total amount of Borrower’s  Subsidiaries’ cash and cash  equivalents at the last day of the  measurement period   $________ Yes No N/A  11)   Total amount of cash and other  assets maintained at Lion as of  the last day of the measurement  period  Total amount not to exceed  $10,000 at any time per Section  7.12 of the Loan Agreement  $_________ Yes No N/A  12)   Total amount of Investments  made by Borrower in Lion during  the current fiscal year as of the  last day of the measurement  period   Total amount not to exceed  $10,000 in any fiscal year per  Permitted Investments (k)(ii) of the  Loan Agreement  $_________ Yes No N/A    Deposit and Securities Accounts  (Please list all accounts; attach separate sheet if additional space needed)     Institution Name Account Number New Account? Account Control Agreement in  place?  1)   Yes No Yes No  2)   Yes No Yes No      3)   Yes No Yes No  4)   Yes No Yes No    Financial Covenants*     Covenant Requirement Actual Compliance  1) Minimum Cash in Blocked  Account See Section 6.10(a)            Yes No         *Borrower shall always comply with the most restrictive unrestricted cash covenant as is required by any term of  this Agreement.    Other Matters    1) Have there been any changes in management since the last Compliance Certificate? Yes No       2) Have there been any transfers/sales/disposals/retirement of Collateral or IP prohibited by  the Loan Agreement? Yes No       3) Have there been any new or pending claims or causes of action against Borrower that  involve more than Five Hundred Thousand Dollars ($500,000.00)? Yes No       4)  Have there been any material amendments of or other material changes to the  capitalization table of Borrower and to the Operating Documents of Borrower or any of  its Subsidiaries?  If yes, provide copies of any such amendments or changes with this  Compliance Certificate.  Yes No        Exceptions    Please explain any exceptions with respect to the certification above: (If no exceptions exist, state “No exceptions.”   Attach separate sheet if additional space needed.)        LEXICON PHARMACEUTICALS, INC.,  for itself and on behalf of each Borrower    By                      Name:                    Title:                      Date:                     LENDER USE ONLY     Received by:                   Date:             Verified by:                     Date:             Compliance Status: Yes  No       Exhibit E      Summary Cash Report                                   1. Most recent month-end date for which this Summary Cash Report applies:                                                 2. Total unrestricted cash, cash equivalents, and short-term investments balance as of the date indicated above:               $                                   3. Blocked Account restricted cash as of the date indicated above:                 $                                   4. Pursuant to section 6.2(a)(v)(i), have all bank statements underlying this Summary Cash Report been attached        and delivered on time? Indicate yes or no.                  Yes:       No:                 
 
 
    Schedule 2.2(b)    [**]