X0708 D LIVE 0001062822 LEXICON PHARMACEUTICALS, INC. 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 281-863-3000 DELAWARE Lexicon Genetics Inc./TX LEXICON PHARMACEUTICALS, INC./DE LEXICON PHARMACEUTICALS, INC./DE LEXICON GENETICS INC/TX Corporation true Raymond Debbane 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Director Phillipe J. Amouyal 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Director Samuel Barker 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Director Ivan H. Cheung 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Director Scott Coiante 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Executive Officer Brian T. Crum 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Executive Officer Lisa DeFrancesco 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Executive Officer Mike Exton 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Executive Officer Director Rachel Martens 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Executive Officer Suma Gopinathan 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Executive Officer Craig B. Granowitz 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Executive Officer Rachel Martens 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Executive Officer Wendy E. McDermott 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Executive Officer Christopher Sobecki 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Director Diane E. Sullivan 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Director Judith L. Swain 2445 Technology Forest Blvd., 11th Floor The Woodlands TX TEXAS 77381 Director Pharmaceuticals Decline to Disclose 06b false 2026-02-02 false true true false 0 59150000 55668255 3481745 Total Offering Amount includes gross proceeds from the private placement of common stock and the issuance of convertible preferred securities, including a partially exercised option to purchase additional convertible preferred securities. false 1 0 0 0 false Lexicon Pharmaceuticals, Inc. /s/ Brian T. Crum Brian T. Crum Senior Vice President and General Counsel 2026-02-17