
| Issuer: | Centene Corporation | 
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| Distribution: | SEC Registered Offering | 
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| Security Description: | 2.50% Senior Notes due 2031 | 
| Aggregate Principal Amount: | $2,200,000,000 | 
| Gross Proceeds: | $2,200,000,000 | 
| Maturity: | March 1, 2031 | 
| Coupon: | 2.50% | 
| Yield to Maturity: | 2.50% | 
| Offering Price: | 100.00% of principal amount | 
| Interest Payment Dates: | March 1 and September 1, commencing September 1, 2021 | 
| Record Dates: | February 15 and August 15 | 
| Optional Redemption: |  | 
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| Make-Whole Call: | Prior to December 1, 2030 (3 months prior to the maturity date), at greater of par and make-whole at discount rate equal to the Treasury Rate plus 50 basis
                points, plus accrued and unpaid interest | 
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| Par Call: | On or after December 1, 2030 (3 months prior to the maturity date), at par, plus accrued and unpaid interest | 
| Change of Control: | Putable at 101% of aggregate principal amount plus accrued and unpaid interest | 
| Trade Date: | February 10, 2021 | 
| Expected Settlement Date:* | (T+4); February 17, 2021 | 
| Use of Proceeds: | The Issuer intends to use the net proceeds from the offering, together with cash on hand, to fund the purchase price of its offer (the “Tender Offer”) to
                purchase for cash any and all of the $2,200,000,000 outstanding aggregate principal amount of its 4.75% Senior Notes due 2025 (the “4.75% 2025 Notes”) and to redeem any 4.75% 2025 Notes that remain outstanding following the Tender Offer
                (the “2025 Notes Redemption”), including all premiums, accrued interest and expenses related to the Tender Offer and the 2025 Notes Redemption. Pending the application of the net proceeds of the offering for the foregoing purposes, net
                proceeds may be temporarily used for general corporate purposes. | 
| CUSIP / ISIN: | 15135BAX9 / US15135BAX91 | 
| Issue Ratings (Moody’s/S&P/Fitch):** | Ba1 / BBB- / BB+ | 
| Denominations/ Multiple: | Denominations of $2,000 and integral multiples of $1,000 in excess thereof | 
| Joint Active Bookrunning Managers: | BofA Securities, Inc. Barclays Capital Inc. | 
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| Joint Bookrunning Managers: | J.P. Morgan Securities LLC Truist Securities, Inc. Wells Fargo Securities, LLC | 
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| Co-Managers: | Fifth Third Securities, Inc. Regions Securities LLC U.S. Bancorp Investments, Inc. MUFG Securities Americas Inc. BMO Capital Markets Corp. PNC Capital Markets LLC CIBC World Markets Corp. Stifel, Nicolaus & Company, Incorporated |