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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13D/A 0001091823 XXXXXXXX LIVE 21 Common Stock 11/19/2025 false 0001356090 46122T102 PRECIGEN, INC. 20374 Seneca Meadows Parkway Germantown MD 20876 Third Security, LLC 5406337900 1881 Grove Avenue Attention: April D. Jones Radford VA 24141 John Owen Gwathmey, Esq. 8046971239 Troutman Pepper Locke Building 1001 Haxall Point Richmond VA 23219 David I. Meyers, Esq. 8046971239 Troutman Pepper Locke Building 1001 Haxall Point Richmond VA 23219 Troutman Pepper Locke, LLP 8046971239 Troutman Pepper Locke Building 1001 Haxall Point Richmond VA 23219 0001091823 N RANDAL J. KIRK b PF N X1 141519399.00 0.00 141519399.00 0.00 141519399.00 N 38.1 IN The indicated amount of Common Stock beneficially owned by Mr. Kirk assumes the full conversion of (i) 906,512 Options to Purchase Common Stock, which are fully vested and exercisable at the discretion of Mr. Kirk, and (ii) 16,666,667 Warrants to Purchase Common Stock, which are fully vested and exercisable at the discretion of Mr. Kirk. Y R.J. KIRK DECLARATION OF TRUST b PF N X1 98831434.00 0.00 98831434.00 0.00 98831434.00 N 26.6 OO OO - trust; The indicated amount of Common Stock beneficially owned by RJ DOT assumes the full conversion of 16,666,667 Warrants to Purchase Common Stock, which are fully vested and exercisable at the discretion of Mr. Kirk. Y THIRD SECURITY, LLC b WC N VA 24487991.00 0.00 24487991.00 0.00 24487991.00 N 6.6 OO OO - limited liability company Common Stock PRECIGEN, INC. 20374 Seneca Meadows Parkway Germantown MD 20876 This Amendment No. 21 (the "Amendment") amends and supplements the Statement on Schedule 13D, dated March 27, 2014 and filed on April 7, 2014, as amended by Amendment No. 1 dated December 31, 2014 and filed on January 5, 2015, by Amendment No. 2 dated May 31, 2016 and filed June 2, 2016, by Amendment No. 3 dated July 24, 2017 and filed July 26, 2017, by Amendment No. 4 dated October 16, 2017 and filed October 23, 2017, by Amendment No. 5 dated December 29, 2017 and filed on January 2, 2018, by Amendment No. 6 dated January 19, 2018 and filed January 22, 2018, by Amendment No. 7 dated July 3, 2018 and filed July 6, 2018, by Amendment No. 8 dated May 13, 2019 and filed May 15, 2019, by Amendment No. 9 dated May 24, 2019 and filed on May 24, 2019, by Amendment No. 10 dated June 6, 2019 and filed on June 10, 2019, by Amendment No. 11 dated January 1, 2020 and filed on January 6, 2020, by Amendment No. 12 dated January 31, 2020 and filed on February 4, 2020, by Amendment No. 13 dated August 11, 2020 and filed on August 13, 2020, by Amendment No. 14 dated December 17, 2020 and filed on December 21, 2020, by Amendment No. 15 dated October 6, 2022 and filed on October 7, 2022, by Amendment No. 16 dated January 27, 2023 and filed on January 31, 2023, by Amendment No. 17 dated May 2, 2024 and filed on May 3, 2024, by Amendment No. 18 dated August 9, 2024 and filed on August 13, 2024, by Amendment No. 19 dated and filed on December 30, 2024, and by Amendment No. 20 dated September 17, 2025 and filed on September 19, 2025 (the "Original Schedule 13D"), relating to the Common Stock, no par value per share (the "Common Stock"), of Precigen, Inc., formerly known as Intrexon Corporation, a Virginia corporation (the "Company"). Mr. Randal J. Kirk ("Mr. Kirk"), the R.J. Kirk Declaration of Trust, a revocable trust established by Mr. Kirk ("RJ DOT"), and Third Security, LLC, a Virginia limited liability company that is controlled by Mr. Kirk ("Third Security" and, together with Mr. Kirk, the RJ DOT, and Third Security, the "Reporting Persons") are filing this Amendment to disclose the sale of an aggregate of 2,966,293 shares of Common Stock by Kapital Joe, LLC, a Virginia limited liability company under the common control of Mr. Kirk ("Kapital Joe"), in open market transactions between November 19, 2025 and November 21, 2025, inclusive. See Original Schedule 13D See Original Schedule 13D See Original Schedule 13D See Original Schedule 13D See Original Schedule 13D See Original Schedule 13D Item 4 of the Original Schedule 13D is hereby amended and supplemented as follows: The information set forth in Items 3 and 6 is incorporated herein by reference. Kapital Joe sold a total of 2,966,293 shares of Common Stock in open market transactions between November 19, 2025 and November 21, 2025, inclusive, for aggregate net proceeds of approximately $12,290,420. The responses to Items 11 and 13 of the cover pages, as well as the applicable comments thereto, to this Amendment No. 21 are incorporated herein. The percentage ownership is calculated based on 353,824,449 shares of Common Stock issued and outstanding as of October 31, 2025, as disclosed in the Company's Quarterly Report on Form 10Q for the period ended September 30, 2025 and filed on November 13, 2025 increased by (i) 16,666,667 shares of Common Stock issuable to Mr. Kirk upon exercise of Warrants to Purchase Common Stock, which are exercisable within sixty (60) days; and (ii) 906,512 shares of Common Stock issuable to Mr. Kirk upon exercise of Options to Purchase Common Stock, which are exercisable within sixty (60) days. The responses to Items 7, 8, 9 and 10 of the cover pages to this Amendment No. 21 are incorporated herein. On September 30, 3025, Sunset 2020, LLC, a Delaware LLC controlled by Mr. Kirk, sold 1,809,667 shares of Common Stock in open market transactions. The shares were sold at a weighted average price of $3.41, for cumulative gross proceeds of approximately $6,168,742. Except as disclosed in the Original 13D and this Amendment No. 21, the Reporting Persons have not engaged in any other transactions within the previous sixty (60) days. Not applicable Not applicable Item 6 of the Original Schedule 13D is hereby amended and supplemented to include the responses in Item 4 above. Exhibit 1 Joint Filing Agreement, dated as of November 21, 2025, by and among Randal J. Kirk, R.J. Kirk Declaration of Trust, and Third Security, LLC. RANDAL J. KIRK /s/ Randal J. Kirk Randal J. Kirk 11/21/2025 R.J. KIRK DECLARATION OF TRUST /s/ Randal J. Kirk Randal J. Kirk Trustee 11/21/2025 THIRD SECURITY, LLC /s/ Randal J. Kirk Randal J. Kirk Managing Member 11/21/2025