<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0502</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001095274</cik>
        <entityName>FIRST NATIONAL BANCSHARES INC /SC/</entityName>
        <issuerAddress>
            <street1>215 N. PINE STREET</street1>
            <street2></street2>
            <city>SPARTANBURG</city>
            <stateOrCountry>SC</stateOrCountry>
            <zipCode>29302</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>8649489001</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>SOUTH CAROLINA</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>J</firstName>
                <middleName>Barry</middleName>
                <lastName>Mason</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>President and Chief Executive Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kitty</firstName>
                <middleName>B</middleName>
                <lastName>Payne</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Executive Vice President and Chief Financial Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>C</firstName>
                <middleName>Dan</middleName>
                <lastName>Adams</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mellnee</firstName>
                <middleName></middleName>
                <lastName>Buchheit</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Martha</firstName>
                <middleName></middleName>
                <lastName>Chapman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>W.</firstName>
                <middleName>Russel</middleName>
                <lastName>Floyd, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>C.</firstName>
                <middleName>Tyrone</middleName>
                <lastName>Gilmore, Sr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Benjamin</firstName>
                <middleName></middleName>
                <lastName>Hines</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>I.S.</firstName>
                <middleName>Leevy</middleName>
                <lastName>Johnson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Norman</firstName>
                <middleName></middleName>
                <lastName>Pulliam</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Joel</firstName>
                <middleName></middleName>
                <lastName>Smith</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName>E.</middleName>
                <lastName>Staton</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <middleName></middleName>
                <lastName>Stern</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Peter</firstName>
                <middleName></middleName>
                <lastName>Weisman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Donald</firstName>
                <middleName>B.</middleName>
                <lastName>Wildman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Coleman</firstName>
                <middleName>L.</middleName>
                <lastName>Young, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>215 N. Pine Street</street1>
                <street2></street2>
                <city>Spartanburg</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29302</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Commercial Banking</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-08-24</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>50000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Howe Barnes Hoefer &amp; Arnett, Inc.</recipientName>
                <recipientCRDNumber>2240</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>222 South Riverside Plaza</street1>
                    <street2>7th Floor</street2>
                    <city>Chicago</city>
                    <stateOrCountry>IL</stateOrCountry>
                    <zipCode>60606</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>DC</state>
                    <state>FL</state>
                    <state>GA</state>
                    <state>IL</state>
                    <state>MD</state>
                    <state>NY</state>
                    <state>NC</state>
                    <state>PA</state>
                    <state>SC</state>
                    <state>TN</state>
                    <state>VA</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>35000000</totalOfferingAmount>
            <totalAmountSold>550500</totalAmountSold>
            <totalRemaining>34449500</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>true</hasNonAccreditedInvestors>
            <numberNonAccreditedInvestors>0</numberNonAccreditedInvestors>
            <totalNumberAlreadyInvested>14</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>483000</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Fee depends on investor classification and amount of shares sold.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>750000</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse>Maximum estimated bonus payments to Chief Executive Officer.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>FIRST NATIONAL BANCSHARES INC /SC/</issuerName>
                <signatureName>/s/ J. Barry Mason</signatureName>
                <nameOfSigner>J. Barry Mason</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2009-09-02</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>