EXHIBIT 8.1
| LIST OF SUBSIDIARIES | |||||
| Name | Jurisdiction | Percentage of ownership | |||
| iOx Therapeutics Limited1 | United Kingdom | 100% | |||
| SalvaRx Limited | British Virgin Islands | 100% | |||
| Tarus Therapeutics Limited1, 2 | British Virgin Islands | 100% | |||
| Saugatuck Therapeutics Limited3 | British Virgin Islands | 70% | |||
| Portage Development Services, Inc. | U.S.A. | 100% | |||
| SalvaRx LLC1 | U.S.A. | 100% | |||
| Saugatuck Rx LLC4 | U.S.A. | 100% | |||
| Tarus Therapeutics LLC | U.S.A. | 100% | |||
| Stimunity S. A.5 | France | 48.9% | |||
| 1 Wholly-owned subsidiary of SalvaRx Limited | |||||
| 2 Formerly Intensity Holdings Limited | |||||
| 3 A subsidiary of SalvaRx Limited | |||||
| 4 Wholly-owned subsidiary of Saugatuck Therapeutics Limited | |||||
| 5 Ownership held through iOx Therapeutics Limited | |||||