August 12, 2025
VIA EDGAR
U.S. Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
| Re: | Plus Therapeutics, Inc. |
Registration Statement on Form S-1 filed on August 12, 2025
File No. 333-289526
Request for Acceleration of Effective Date
Ladies and Gentlemen:
Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended, Plus Therapeutics, Inc. hereby requests for acceleration of the effective date of the above-referenced registration statement, as amended, so that it becomes effective as of 5:30 p.m. Eastern Time on Thursday, August 14, 2025, or as soon thereafter as possible.
[Signature Page to Follow]
| Very truly yours,
| ||
| Plus Therapeutics, Inc.
| ||
| By: | /s/ Andrew Sims | |
| Name: Andrew Sims | ||
| Title: Chief Financial Officer | ||
cc: Aaron M. Schleicher, Sullivan & Worcester LLP
[Signature Page to Acceleration Request]