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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13D 0002106704 XXXXXXXX LIVE Common Stock 01/15/2026 false 0001098972 00847G804 AGENUS INC 3 FORBES ROAD LEXINGTON MA 02421 Ravi Yadavar 609-730-1900 73 Route 31, North Pennington NJ 08534 0002106704 N ZYNEXT VENTURES USA LLC b WC N DE 0.00 2133333.00 0.00 2133333.00 2133333.00 N 5.9 OO Limited liability company Y ZYNEXT VENTURES PTE LTD b AF N U0 0.00 2133333.00 0.00 2133333.00 2133333.00 N 5.9 HC OO Private limited company; parent of Zynext Ventures USA LLC. Y ZYDUS LIFESCIENCES LTD b AF N K7 0.00 2133333.00 0.00 2133333.00 2133333.00 N 5.9 HC OO Public limited company; parent of Zynext Ventures Pte. Ltd. Common Stock AGENUS INC 3 FORBES ROAD LEXINGTON MA 02421 This Schedule 13D is being filed by Zynext Ventures USA LLC, Zynext Ventures Pte Ltd., and Zydus Lifesciences Ltd. (collectively "Zydus", and each a "Reporting Person"). Zynext Ventures USA LLC is wholly owned by Zynext Ventures Pte Ltd., which is wholly owned by Zydus Lifesciences Ltd. Zydus Lifesciences Ltd. is an Indian public limited company, with shares listed on multiple stock exchanges in India. The agreement among the Reporting Persons to file this Schedule 13D jointly in accordance with Rule 13D-1(k) of the Securities Exchange Act of 1934, as amended, is attached as Exhibit 7 hereto. The address of the principal business office of Zynext Ventures USA LLC is 73 Route 31 North, Pennington, NJ 08534. The principal business of Zydus is pharmaceuticals and investments in biotechnology companies. Within the past five years, Zydus has not been convicted in a criminal proceeding (excluding traffic violations and similar misdemeanors). During the last five years, Zydus has not been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree of final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws. Not applicable. The shares of Common Stock purchased by Zynext Ventures USA LLC pursuant to the Securities Purchase Agreement were purchased using the working capital of the Zynext Ventures USA LLC for an aggregate purchase price of approximately $16.0 million or $7.50 per share. The acquisition of securities of the issuer is part of a strategic collaboration between Zydus and the issuer. At Zydus?s option, Zydus may appoint either a board observer or board member to issuer?s board of directors so long as Zydus retains significant ownership of issuer?s stock. The information set forth in rows 11 and 13 of the cover pages to this Schedule 13D is incorporated by reference. The percentages set forth in row 13 are based on an aggregate of 36,141,682 shares of Common Stock outstanding, consisting of (i) 34,008,349 shares of Common Stock outstanding as of November 7, 2025, as disclosed by the Issuer in its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the "SEC") on November 10, 2025, and (ii) 2,133,333 shares of Common Stock issued to Zydus. The information set forth in rows 7 through 10 of the cover pages to this Schedule 13D is incorporated by reference. On January 15, 2026, Zynext Ventures USA LLC (and thus, indirectly, Zynext Ventures Pte Ltd and Zydus Lifesciences Ltd) acquired 2,133,333 shares of Common Stock, at a purchase price of $7.50 per share, pursuant to the transactions contemplated by the Securities Purchase Agreement. Except for the transactions described in this Item 5(c), none of the Reporting Persons has affected any transaction in shares of Common Stock during the past 60 days. Not applicable. Not applicable. On June 3, 2025, the issuer entered into three agreements with the Zynext Ventures USA LLC and its affiliates: 1) the Securities Purchase Agreement to purchase the common stock reported on this Schedule 13D, 2) an Asset Purchase Agreement, pursuant to which Zydus?s affiliate agreed to purchase certain manufacturing operations, real estate, equipment, and certain contracts from the issuer in exchange for cash, and 3) a License Agreement, pursuant to which the issuer granted Zydus Lifesciences Ltd an exclusive license to develop, manufacture and commercialize botensilimab and balstilimab in India and Sri Lanka in exchange for a royalty on net sales. On January 15, 2026, the transactions contemplated by these agreements were closed. At Zydus?s option, Zydus may appoint either a board observer or board member to issuer?s board of directors so long as Zydus retains significant ownership of issuer?s stock. As part of the Securities Purchase Agreement, the issuer has agreed to prepare and file a registration statement to register the resale of the shares of Common Stock purchased pursuant to the Securities Purchase Agreement within 60 calendar days after the date of the Closing and to use commercially reasonable efforts to have the registration statement declared effective within (a) 75 calendar days after the closing date, or (b) if the SEC notifies the Issuer that it will review the registration statement, 120 days following the closing date. The foregoing descriptions do not purport to be complete and are qualified in their entirety by reference to the full text of the agreements, incorporated by reference as exhibits hereto. Exhibit 7 Joint Filing Agreement Exhibit 8 Securities Purchase Agreement (incorporated by reference to Exhibit 10.3 to the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 11, 2025) Exhibit 9 Asset Purchase Agreement (incorporated by reference to Exhibit 10.1 to the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 11, 2025) Exhibit 10 License Agreement (incorporated by reference to Exhibit 10.2 to the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 11, 2025) (20,000-character limit, line endings allowed, no formatting permitted) ZYNEXT VENTURES USA LLC Ravi Yadavar Board of Managers 01/22/2026 ZYNEXT VENTURES PTE LTD Tan Sock Kheng Director 01/22/2026 ZYDUS LIFESCIENCES LTD Mukund Thakkar Sr. Vice President, Legal 01/22/2026 Not applicable.