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Exhibit 21.1

The following is a list of subsidiaries of Edwards Lifesciences Corporation, omitting subsidiaries which, considered in the aggregate as a single subsidiary, would not constitute a significant subsidiary as of December 31, 2025:

Legal Entity

State of Incorporation/ Formation

Country of Incorporation/ Formation

Edwards Lifesciences LLC

Delaware

U.S.

Edwards Lifesciences Holding, Inc.

Delaware

U.S.

Edwards Lifesciences (U.S.) Inc.

Delaware

U.S.

Edwards Lifesciences SAS

France

Edwards Lifesciences (Japan) LLC

Japan

Edwards Lifesciences Services GmbH

Germany

Edwards Lifesciences Limited

U.K.