X0609 4 2026-05-13 0 0001104506 INSMED Inc INSM 0001182633 SHAROKY MELVIN MD false 700 US HIGHWAY 202/206 BRIDGEWATER NJ 08807 1 0 0 0 0 Common Stock 2026-05-13 4 A 0 3305 A 246081 D Common Stock 6847 I By spouse Common Stock 5000 I By Padonia, LLC Common Stock 819 I By Melvin Sharoky C/F Adler J. Wink UTMA/FL Common Stock 5423 I By Melvin Sharoky C/F Nolan M. Wink UTMA/FL Common Stock 5007 I By Melvin Sharoky C/F Sophie C. Wink UTMA/FL Common Stock 3724 I By Melvin Sharoky C/F Tulia L. Sharoky UTMA/FL Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock. The RSUs vest in full on the first anniversary of the grant date (the Vesting Date), provided that the director (a) remains a member of the Board of Directors of the issuer until the earlier of (i) such Vesting Date and (ii) the Company's Annual Shareholder Meeting in the year of such Vesting Date, and (b) attends at least 75% of the meetings of the Board of Directors which take place between the grant date and the first anniversary of the grant date. Each RSU was granted on May 13, 2026, for no consideration. The Reporting Person is the managing member of Padonia, LLC. The Reporting Person is the custodian of Melvin Sharoky C/F Adler J. Wink UTMA/FL. The Reporting Person is the custodian of Melvin Sharoky C/F Nolan M. Wink UTMA/FL. The Reporting Person is the custodian of Melvin Sharoky C/F Sophie C. Wink UTMA/FL. The Reporting Person is the custodian of Melvin Sharoky C/F Tulia L. Sharoky UTMA/FL. /s/ Melvin Sharoky, M.D, by Michael A. Smith as Attorney-in-fact 2026-05-15