Table 1 – Newly Registered Securities

Security Type

Security Class Title

Fee Calculation Rule

Amount Registered⁽¹⁾

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Equity

Common Stock, $0.001 par value per share, reserved for issuance under the 2016 Equity Incentive Plan

457(c) and 457(h)

1,236,871⁽²⁾

$71.34⁽⁴⁾

$88,238,377.14

$92.70 per $1,000,000

$8,180

Equity

Common Stock, $0.001 par value per share, reserved for issuance under the 2016 Employee Stock Purchase Plan

457(c) and 457(h)

247,374⁽³⁾

$60.64⁽⁵⁾

$15,000,759.36

$92.70 per $1,000,000

$1,391

Total Offering Amounts

$9,571

Total Fee Offsets

–

Net Fee Due

$9,571

(1)

Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement shall also cover any additional shares of the Registrant’s common stock that become issuable under the 2016 Equity Incentive Plan (the “2016 Plan”) and the 2016 Employee Stock Purchase Plan (the “2016 ESPP”) by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of the Registrant’s outstanding shares of common stock.

(2)

Reflects an automatic annual increase to the number of shares of the Registrant’s common stock reserved for issuance pursuant to future awards under the 2016 Plan, which annual increase is provided for in the 2016 Plan.

(3)

Reflects an automatic annual increase to the number of shares of the Registrant’s common stock reserved for issuance under the 2016 ESPP, which annual increase is provided for in the 2016 ESPP.

(4)

Estimated in accordance with Rules 457(c) and 457(h) of the Securities Act solely for purposes of calculating the registration fee on the basis of $71.34, the average of the high and low prices of the Registrant’s common stock, as reported on the Nasdaq Global Market on February 11, 2022.

(5)

Estimated in accordance with Rules 457(c) and 457(h) of the Securities Act solely for purposes of calculating the registration fee on the basis of 85% of $71.34, the average of the high and low prices of the Registrant’s common stock, as reported on the Nasdaq Global Market on February 11, 2022. Pursuant to the 2016 ESPP, the purchase price of the shares of common stock reserved for issuance thereunder will be 85% of the lower of the fair market value of the common stock on (i) the first trading day of the offering period or (ii) the end of each purchase period within the offering period.

Table 2 – Fee Offset Claims and Sources

Registrant or Filer Name

Form or Filing Type

File Number

Initial Filing Date

Filing Date

Fee Offset Claimed

Security Type Associated with Fee Offset Claimed

Unsold Securities Associated with Fee Offset Claimed

Unsold Aggregate Offering Amount Associated with Fee Offset Claimed

Fee Paid with Fee Offset Source

Rule 457(p)

Fee Offset Claims

Fee Offset Sources