X0202 SCHEDULE 13D/A 0000902664-25-004014 0001478982 XXXXXXXX LIVE 3 Common Stock, par value $0.000001 per share 03/17/2026 false 0001116463 68554V108 ORASURE TECHNOLOGIES INC

220 E First St Bethlehem PA 18015

Rishi Bajaj 949-326-9612 Altai Capital Management, L.P. PO Box 15203 Irvine CA 92623-9998 Ele Klein 212-756-2000 McDermott Will & Schulte LLP 919 Third Avenue New York NY 10022 0001478982 N Altai Capital Management, L.P. b AF N DE 0.00 3613836.00 0.00 3613836.00 3613836.00 N 5.2 IA PN 0001619440 N Altai Capital Management, LLC b AF N DE 0.00 3613836.00 0.00 3613836.00 3613836.00 N 5.2 HC OO 0001619438 N Rishi Bajaj b AF N X1 0.00 3613836.00 0.00 3613836.00 3613836.00 N 5.2 IN HC Common Stock, par value $0.000001 per share ORASURE TECHNOLOGIES INC 220 E First St Bethlehem PA 18015 This Amendment No. 3 ("Amendment No. 3") amends the statement on Schedule 13D filed with the SEC on September 9, 2025 (as amended from time to time, the "Schedule 13D") with respect to the shares of Common Stock of the Issuer held for the account of Osprey and the Separately Managed Accounts. This Amendment No. 3 amends Items 4, 5 and 7 as set forth below. Capitalized terms used herein and not otherwise defined in this Amendment No. 3 have the meanings set forth in the Schedule 13D. Item 4 is hereby amended and supplemented as follows: On March 17, 2026, Investment Manager issued a press release containing an open letter (the "March 17 Letter") to the Board outlining its case for change at the Issuer and reiterating its intention to solicit proxies from the stockholders to elect Rishi Bajaj and John Bertrand at the Annual Meeting. The foregoing description of the March 17 Letter does not purport to be complete and is qualified in its entirety by reference to the full text of the March 17 Letter, which is filed as Exhibit 99.3 and is incorporated herein by reference. Item 5(a) is hereby amended and restated in its entirety as follows: The responses of the Reporting Persons to rows (11) through (13) of the cover pages of this Schedule 13D are incorporated herein by reference. All percentages set forth herein are based upon a total of 69,126,173 shares of Common Stock outstanding as of February 28, 2026, as reported in the Issuer's annual report on Form 10-K for the fiscal year ended December 31, 2025, filed with the SEC on March 9, 2026. For purposes of disclosing the number of shares of Common Stock beneficially owned by each of the Reporting Persons, Investment Manager, IMGP, and Mr. Bajaj may be deemed to own beneficially (as that term is defined in Rule 13d-3 under the Act) all shares of Common Stock that are owned beneficially and directly by the Reporting Persons. Each of Investment Manager, IMGP and Mr. Bajaj disclaims beneficial ownership of such shares of Common Stock for all other purposes. Item 5(b) is hereby amended and restated in its entirety as follows: The responses of the Reporting Persons to rows (7) through (10) of the cover pages of this Schedule 13D are incorporated herein by reference. Item 5(c) is hereby amended and restated in its entirety as follows: Information concerning transactions in the shares of Common Stock effected by the Reporting Persons during the past sixty days is set forth in Schedule A hereto and is incorporated herein by reference. Item 5(d) is hereby amended and restated in its entirety as follows: No persons other than the Reporting Persons, Osprey and the Separately Managed Accounts are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the shares of Common Stock covered by this Schedule 13D that may be deemed to be beneficially owned by the Reporting Persons. Item 5(e) is hereby amended and restated in its entirety as follows: Not applicable. Item 7 is hereby amended and supplemented as follows: Exhibit 99.3: March 17 Letter Altai Capital Management, L.P. /s/ Rishi Bajaj 03/17/2026 Altai Capital Management, LLC /s/ Rishi Bajaj 03/17/2026 Rishi Bajaj /s/ Rishi Bajaj 03/17/2026