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Filed pursuant to Rule 433

Registration Statement No. 333-278506

Sanofi

Pricing Term Sheet for the 2028 Fixed Rate Notes

U.S.$400,000,000 3.800% Notes due 2028 (the “2028 Fixed Rate Notes”)

 

Issuer    Sanofi
Format    SEC-registered global notes
Title    3.800% Notes due 2028 (the “2028 Fixed Rate Notes”)
Principal    U.S.$400,000,000
Issue Price    99.994% plus accrued interest, if any, from November 3, 2025
Pricing Date    October 27, 2025
Expected Settlement Date    November 3, 2025 (T+5)
Maturity Date    November 3, 2028
Day Count    30/360
Day Count Convention    Following unadjusted
Optional Redemption    Make-whole call at Treasury Rate plus 5 bps before October 3, 2028
   Par call at 100% principal amount on or after October 3, 2028
Tax Redemption    Applicable
Ranking    Unsecured and unsubordinated
Interest Rate    3.800% per annum
Benchmark Treasury    3.500% due October 15, 2028
Benchmark Treasury Price    99-31 3/4
Benchmark Treasury Yield    3.502%
Spread to Benchmark Treasury    +30bps
Yield to Maturity    3.802%
Date Interest Starts Accruing    November 3, 2025
Interest Payment Dates    Each November 3 and May 3, commencing May 3, 2026
Regular record dates for interest    Each October 19 and April 18
Trustee    Deutsche Bank Trust Company Americas
Listing    None
Denominations    U.S.$2,000 and increments of U.S.$1,000 above that amount
Expected Ratings of the Notes*    Moody’s: Aa3/Stable
   Standard & Poor’s: AA/Stable
   Scope Ratings: AA/Stable
CUSIP/ISIN    801060 AG9 / US801060AG91


Global Coordinators and Joint Book- Running Managers    Barclays Capital Inc., BNP Paribas Securities Corp., BofA Securities, Inc.
Joint Book-Running Managers    J.P. Morgan Securities LLC, Morgan Stanley & Co. LLC, MUFG Securities Americas Inc., Natixis Securities Americas LLC

 

*

A securities rating is not a recommendation to buy, sell or hold securities and may be subject to revision or withdrawal at any time.

It is expected that delivery of the notes will be made against payment on November 3, 2025 (such settlement being referred to as “T+5”). Under Rule 15c6-1 under the Securities Exchange Act of 1934, trades in the secondary market are required to settle in one business day, unless the parties to any such trade expressly agree otherwise. Accordingly, purchasers who wish to trade notes prior to one business day before delivery of the notes hereunder will be required, by virtue of the fact that the notes initially settle in T+5, to specify an alternate settlement arrangement at the time of any such trade to prevent a failed settlement. Purchasers of the notes who wish to trade the notes prior their date of delivery hereunder should consult their advisors.

The issuer has filed a registration statement (including a prospectus) with the SEC for the offering to which this communication relates. Before you invest, you should read the prospectus in that registration statement and other documents the issuer has filed with the SEC for more complete information about the issuer and this offering. You may obtain these documents for free by visiting EDGAR on the SEC Web site at www.sec.gov. Alternatively, copies may be obtained from Barclays Capital Inc. toll-free at 1-888-603-5847, BNP Paribas Securities Corp. toll-free at 1-800-854-5674 and BofA Securities, Inc. toll-free at 1-800-294-1322.

ANY DISCLAIMERS OR OTHER NOTICES THAT MAY APPEAR BELOW ARE NOT APPLICABLE TO THIS COMMUNICATION AND SHOULD BE DISREGARDED. SUCH DISCLAIMERS OR OTHER NOTICES WERE AUTOMATICALLY GENERATED AS A RESULT OF THIS COMMUNICATION BEING SENT VIA BLOOMBERG OR ANOTHER EMAIL SYSTEM.