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EXHIBIT 21

SUBSIDIARIES OF EXACT SCIENCES CORPORATION

Registrant’s consolidated subsidiaries are shown below, together with the state or jurisdiction of organization of each subsidiary and the percentage of voting securities that Registrant owns in each subsidiary.

Name of Subsidiary						Jurisdiction of Incorporation or Organization						Percent of Outstanding Voting Securities Owned as of December 31, 2024
Genomic Health, Inc.						Delaware						100			%
Exact Sciences Laboratories, LLC						Delaware						100			%
Exact Sciences Thrive, LLC						Delaware						100			%