EXHIBIT 32.1

CERTIFICATION
PURSUANT TO 18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

     In connection with the Annual Report on Form 10-K of Iomai Corporation (the “Company”) for the year ended December 31, 2007 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), each of the undersigned to his knowledge hereby certifies, pursuant to 18 U.S.C. Section 1350, that:

	(i)		The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
	(ii)		The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

		/s/ Stanley C. Erck
		Stanley C. Erck
		Chief Executive Officer
		/s/ Russell P. Wilson
		Russell P. Wilson
		Chief Financial Officer

Dated: March 26, 2008