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      <liveTestFlag>LIVE</liveTestFlag>
      <filer>
        <issuerCredentials>
          <cik>0001133818</cik>
          <ccc>XXXXXXXX</ccc>
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      <issuerName>BIO-PATH HOLDINGS, INC.</issuerName>
      <jurisdictionOrganization>WY</jurisdictionOrganization>
      <yearIncorporation>2000</yearIncorporation>
      <cik>0001133818</cik>
      <sicCode>2834</sicCode>
      <irsNum>87-0652870</irsNum>
      <fullTimeEmployees>1</fullTimeEmployees>
      <partTimeEmployees>0</partTimeEmployees>
    </employeesInfo>
    <issuerInfo>
      <street1>4710 BELLAIRE BOULEVARD</street1>
      <street2>SUITE 210</street2>
      <city>BELLAIRE</city>
      <stateOrCountry>TX</stateOrCountry>
      <zipCode>77401</zipCode>
      <phoneNumber>630-708-0750</phoneNumber>
      <connectionName>Capital Markets Law Group, LLP</connectionName>
      <industryGroup>Other</industryGroup>
      <cashEquivalents>0.00</cashEquivalents>
      <investmentSecurities>0.00</investmentSecurities>
      <accountsReceivable>0.00</accountsReceivable>
      <propertyPlantEquipment>0.00</propertyPlantEquipment>
      <totalAssets>678000.00</totalAssets>
      <accountsPayable>7914000.00</accountsPayable>
      <longTermDebt>14000.00</longTermDebt>
      <totalLiabilities>8899000.00</totalLiabilities>
      <totalStockholderEquity>-8221000.00</totalStockholderEquity>
      <totalLiabilitiesAndEquity>678000.00</totalLiabilitiesAndEquity>
      <totalRevenues>0.00</totalRevenues>
      <costAndExpensesApplToRevenues>0.00</costAndExpensesApplToRevenues>
      <depreciationAndAmortization>0.00</depreciationAndAmortization>
      <netIncome>-8674000.00</netIncome>
      <earningsPerShareBasic>-1.10</earningsPerShareBasic>
      <earningsPerShareDiluted>-1.10</earningsPerShareDiluted>
    </issuerInfo>
    <commonEquity>
      <commonEquityClassName>Common Shares</commonEquityClassName>
      <outstandingCommonEquity>9342151</outstandingCommonEquity>
      <commonCusipEquity>09057N409</commonCusipEquity>
      <publiclyTradedCommonEquity>OTC Pink</publiclyTradedCommonEquity>
    </commonEquity>
    <preferredEquity>
      <preferredEquityClassName>Series S</preferredEquityClassName>
      <outstandingPreferredEquity>51</outstandingPreferredEquity>
      <preferredCusipEquity>000000000</preferredCusipEquity>
      <publiclyTradedPreferredEquity>N/A</publiclyTradedPreferredEquity>
    </preferredEquity>
    <debtSecurities>
      <debtSecuritiesClassName>N/A</debtSecuritiesClassName>
      <outstandingDebtSecurities>0</outstandingDebtSecurities>
      <cusipDebtSecurities>000000000</cusipDebtSecurities>
      <publiclyTradedDebtSecurities>N/A</publiclyTradedDebtSecurities>
    </debtSecurities>
    <issuerEligibility>
      <certifyIfTrue>true</certifyIfTrue>
    </issuerEligibility>
    <applicationRule262>
      <certifyIfNotDisqualified>true</certifyIfNotDisqualified>
    </applicationRule262>
    <summaryInfo>
      <indicateTier1Tier2Offering>Tier1</indicateTier1Tier2Offering>
      <financialStatementAuditStatus>Unaudited</financialStatementAuditStatus>
      <securitiesOfferedTypes>Equity (common or preferred stock)</securitiesOfferedTypes>
      <offerDelayedContinuousFlag>Y</offerDelayedContinuousFlag>
      <offeringYearFlag>N</offeringYearFlag>
      <offeringAfterQualifFlag>N</offeringAfterQualifFlag>
      <offeringBestEffortsFlag>Y</offeringBestEffortsFlag>
      <solicitationProposedOfferingFlag>N</solicitationProposedOfferingFlag>
      <resaleSecuritiesAffiliatesFlag>N</resaleSecuritiesAffiliatesFlag>
      <securitiesOffered>20000000</securitiesOffered>
      <outstandingSecurities>9342151</outstandingSecurities>
      <pricePerSecurity>0.0300</pricePerSecurity>
      <issuerAggregateOffering>600000.00</issuerAggregateOffering>
      <securityHolderAggegate>0.00</securityHolderAggegate>
      <qualificationOfferingAggregate>0.00</qualificationOfferingAggregate>
      <concurrentOfferingAggregate>0.00</concurrentOfferingAggregate>
      <totalAggregateOffering>600000.00</totalAggregateOffering>
      <legalServiceProviderName>Capital Markets Law Group, LLP</legalServiceProviderName>
      <legalFees>15000.00</legalFees>
      <blueSkyServiceProviderName>Various State Filing Fees</blueSkyServiceProviderName>
      <blueSkyFees>5000.00</blueSkyFees>
    </summaryInfo>
    <juridictionSecuritiesOffered>
      <jurisdictionsOfSecOfferedNone>true</jurisdictionsOfSecOfferedNone>
      <issueJuridicationSecuritiesOffering>FL</issueJuridicationSecuritiesOffering>
      <issueJuridicationSecuritiesOffering>NY</issueJuridicationSecuritiesOffering>
      <issueJuridicationSecuritiesOffering>VA</issueJuridicationSecuritiesOffering>
    </juridictionSecuritiesOffered>
    <securitiesIssued>
      <securitiesIssuerName>Bio-Path Holdings, Inc.</securitiesIssuerName>
      <securitiesIssuerTitle>Common Stock and Series S Preferred Stock</securitiesIssuerTitle>
      <securitiesIssuedTotalAmount>3574000</securitiesIssuedTotalAmount>
      <securitiesPrincipalHolderAmount>0</securitiesPrincipalHolderAmount>
      <securitiesIssuedAggregateAmount>The aggregate consideration for the common stock securities issued was $110,000. This consists of $104,000 in extinguished principal and interest of outstanding debt, and $6,000 representing the fair market value of professional services rendered to the Company. The aggregate consideration for the Series S Preferred stock was $3.</securitiesIssuedAggregateAmount>
    </securitiesIssued>
    <unregisteredSecuritiesAct>
      <securitiesActExcemption>Section 4(a)(2) of the Securities Act of 1933 for transactions by an issuer not involving any public offering.</securitiesActExcemption>
    </unregisteredSecuritiesAct>
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