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Exhibit 21.1

Subsidiaries

Set forth below is a list of subsidiaries of the Registrant as of December 31, 2025. Certain foreign subsidiaries have been omitted from the list below in accordance with Item 601(b)(21)(ii) of Regulation S-K.

Name			Jurisdiction of Incorporation
Madrigal Pharmaceuticals B.V.			Netherlands
Madrigal Pharmaceuticals GmbH			Switzerland
Madrigal Pharmaceuticals Deutschland GmbH			Germany