Exhibit 3.1
AMENDMENT TO
SECOND AMENDED AND RESTATED BY-LAWS
OF
AMICUS THERAPEUTICS, INC.
ARTICLE VI
MISCELLANEOUS MANAGEMENT PROVISIONS
6.5. Exclusive Jurisdiction of Delaware Courts or the United States Federal District Courts. Unless the
Company consents in writing to the selection of an alternative forum, the Court of Chancery of the State of Delaware (or, if such court does not have jurisdiction thereof, another state court or a federal district court located within the State
of Delaware) shall be the sole and exclusive forum for (i) any derivative action or proceeding brought on behalf of the Company, (ii) any action asserting a claim of, or a claim based on, a breach of a fiduciary duty owed by any current or former
director, officer or other employee of the Company to the Company or the Company’s stockholders, (iii) any action asserting a claim arising pursuant to any provision of the DGCL or the Certificate of Incorporation or these by-laws (including the
interpretation, validity or enforceability thereof), or (iv) any action asserting a claim governed by the internal affairs doctrine. Unless the Company consents in writing to the selection of an alternative forum, the federal district courts of
the United States of America shall be the sole and exclusive forum for resolving any complaint asserting a cause of action arising under the Securities Act of 1933, as amended. Any person or entity purchasing or otherwise acquiring any interest
in shares of capital stock of the Company shall be deemed to have notice of and consented to the provisions of this Section 6.5.