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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13D/A 0001224962 XXXXXXXX LIVE 6 Common Stock, $0.001 par value 08/12/2025 false 0001327273 55234L105 Lyra Therapeutics, Inc. 480 Arsenal Way Watertown MA 02472 Alexander Rakitin (646) 205-5345 51 Astor Place, 10th Floor New York NY 10003 0001224962 N Perceptive Advisors LLC b AF N DE 0 255750 0 255750 255750 N 15.55 IA 0001164426 N Joseph Edelman b AF N X1 0 255750 0 255750 255750 N 15.55 IN 0001249675 N Perceptive Life Sciences Master Fund, Ltd. b WC N E9 0 229982 0 229982 229982 N 13.99 CO 0001797811 N Perceptive LS (A), LLC b WC N E9 0 25768 0 25768 25768 N 1.57 CO Common Stock, $0.001 par value Lyra Therapeutics, Inc. 480 Arsenal Way Watertown MA 02472 The information set forth in rows 11 and 13 of the cover pages to this Schedule 13D is incorporated by reference. The percentage set forth in row 13 is based on 1,644,454 outstanding shares of Common Stock as of August 8, 2025 as reported by the Issuer in its Form 10-Q filed with the Securities and Exchange Commission on August 12, 2025. The information set forth in rows 7 through 10 of the cover pages to this Schedule 13D is incorporated by reference. Perceptive Advisors LLC /s/ Joseph Edelman Joseph Edelman, Managing Member 08/14/2025 Joseph Edelman /s/ Joseph Edelman Joseph Edelman 08/14/2025 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman Joseph Edelman, Managing Member 08/14/2025 Perceptive LS (A), LLC Perceptive LS GP, LLC Joseph Edelman, Member 08/14/2025 /s/ Joseph Edelman Joseph Edelman, Member 08/14/2025