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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   10,882,542 5,360,858 SH   SOLE   5,360,858 0 0
ADAGIO MED HLDGS INC COM 00534B100   7,898,997 9,812,419 SH   SOLE   9,812,419 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109   6,917,122 930,972 SH   SOLE   930,972 0 0
ADMA BIOLOGICS INC COM 000899104   27,244,943 1,373,233 SH   SOLE   1,373,233 0 0
AKERO THERAPEUTICS INC COM 00973Y108   32,099,021 792,960 SH   SOLE   792,960 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   53,336,143 9,275,851 SH   SOLE   9,275,851 0 0
AMICUS THERAPEUTICS INC COM 03152W109   175,150,540 21,464,527 SH   SOLE   21,464,527 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   27,875,192 7,874,348 SH   SOLE   7,874,348 0 0
ANTERIS TECHNOLOGIES GLOBAL COM 03675P102   7,789,600 2,140,000 SH   SOLE   2,140,000 0 0
APOGEE THERAPEUTICS INC COM 03770N101   41,946,575 1,122,767 SH   SOLE   1,122,767 0 0
APPLIED THERAPEUTICS INC COM 03828A101   420,454 860,000 SH   SOLE   860,000 0 0
APYX MEDICAL CORPORATION COM 03837C106   205,500 150,000 SH   SOLE   150,000 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104   10,808,903 3,727,208 SH   SOLE   3,727,208 0 0
ARCELLX INC COMMON STOCK 03940C100   191,976,957 2,926,478 SH   SOLE   2,926,478 0 0
ARGENX SE SPONSORED ADR 04016X101   35,221,886 59,510 SH   SOLE   59,510 0 0
ARTIVION INC COM 228903100   68,669,220 2,793,703 SH   SOLE   2,793,703 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   34,632,142 6,485,420 SH   SOLE   6,485,420 0 0
ATHIRA PHARMA INC COM 04746L104   1,539,304 5,402,964 SH   SOLE   5,402,964 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306   4,165,200 520,000 SH   SOLE   520,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104   41,416,129 355,107 SH   SOLE   355,107 0 0
BETA BIONICS INC COM 08659B102   19,505,762 1,593,608 SH   SOLE   1,593,608 0 0
BIODESIX INC COM 09075X108   1,358,675 2,173,880 SH   SOLE   2,173,880 0 0
BOSTON SCIENTIFIC CORP COM 101137107   13,114,400 130,000 SH   SOLE   130,000 0 0
BRIGHT MINDS BIOSCIENCES INC COM NEW 10919W405   16,038,489 444,649 SH   SOLE   444,649 0 0
CARGO THERAPEUTICS INC COM 14179K101   9,894,515 2,431,085 SH   SOLE   2,431,085 0 0
CELCUITY INC COM 15102K100   23,882,641 2,362,279 SH   SOLE   2,362,279 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   43,720,880 3,040,395 SH   SOLE   3,040,395 0 0
CONTINEUM THERAPEUTICS INC CL A 21217B100   10,059,918 1,441,249 SH   SOLE   1,441,249 0 0
CULLINAN THERAPEUTICS INC COM 230031106   606,357 80,100 SH   SOLE   80,100 0 0
DELCATH SYS INC COM NEW 24661P807   5,886,632 462,422 SH   SOLE   462,422 0 0
DEXCOM INC COM 252131107   12,155,620 178,000 SH   SOLE   178,000 0 0
DISC MEDICINE INC COM 254604101   7,446,000 150,000 SH   SOLE   150,000 0 0
DYNE THERAPEUTICS INC COM 26818M108   24,198,195 2,313,403 SH   SOLE   2,313,403 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   144,041,216 6,547,328 SH   SOLE   6,547,328 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   11,000,000 500,000 SH Call SOLE   500,000 0 0
ENSYSCE BIOSCIENCES INC COM NEW 293602504   221,865 86,666 SH   SOLE   86,666 0 0
EVOLUS INC COM 30052C107   49,673,578 4,129,142 SH   SOLE   4,129,142 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209   8,332,025 1,537,274 SH   SOLE   1,537,274 0 0
HELIX ACQUISITION CORP II CL A ORD SHS G4444H101   4,497,400 398,000 SH   SOLE   398,000 0 0
IMMATICS N.V SHS N44445109   42,319,387 9,383,456 SH   SOLE   9,383,456 0 0
IMMUNOVANT INC COM 45258J102   48,605,190 2,844,072 SH   SOLE   2,844,072 0 0
INHIBIKASE THERAPEUTICS INC COM NEW 45719W205   12,975,750 5,925,000 SH   SOLE   5,925,000 0 0
INHIBRX BIOSCIENCES INC COM 45720N103   14,885,723 1,064,026 SH   SOLE   1,064,026 0 0
INSMED INC COM PAR $.01 457669307   38,854,497 509,300 SH   SOLE   509,300 0 0
INSULET CORP COM 45784P101   18,802,088 71,597 SH   SOLE   71,597 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   103,736,347 786,358 SH   SOLE   786,358 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   20,117,372 40,619 SH   SOLE   40,619 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   42,330,254 12,711,788 SH   SOLE   12,711,788 0 0
JANUX THERAPEUTICS INC COM 47103J105   26,201,124 970,412 SH   SOLE   970,412 0 0
KALA BIO INC COM NEW 483119202   1,590,705 277,610 SH   SOLE   277,610 0 0
KESTRA MED TECHNOLOGIES LTD SHS G52441105   4,984,000 200,000 SH   SOLE   200,000 0 0
LEXEO THERAPEUTICS INC COM 52886X107   485,227 139,835 SH   SOLE   139,835 0 0
LYRA THERAPEUTICS INC COM 55234L105   1,607,453 12,757,562 SH   SOLE   12,757,562 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   15,402,195 46,500 SH   SOLE   46,500 0 0
MEIRAGTX HLDGS PLC COM G59665102   85,254,892 12,581,103 SH   SOLE   12,581,103 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107   1,973,162 876,961 SH   SOLE   876,961 0 0
MERUS N V COM N5749R100   29,062,514 690,485 SH   SOLE   690,485 0 0
NANOBIOTIX SPONSORED ADS 63009J107   376,090 105,053 SH   SOLE   105,053 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108   10,843,615 12,594,211 SH   SOLE   12,594,211 0 0
NEUROCRINE BIOSCIENCES COM 64125C109   11,065,530 100,050 SH   SOLE   100,050 0 0
NURIX THERAPEUTICS INC COM 67080M103   3,534,930 297,553 SH   SOLE   297,553 0 0
NUVALENT INC COM 670703107   115,881,011 1,633,968 SH   SOLE   1,633,968 0 0
OCULAR THERAPEUTIX INC COM 67576A100   6,712,631 915,775 SH   SOLE   915,775 0 0
ONKURE THERAPEUTICS INC COM CL A 68277Q105   4,319,088 1,004,439 SH   SOLE   1,004,439 0 0
OPUS GENETICS INC COM 67577R102   4,246,285 4,325,000 SH   SOLE   4,325,000 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   19,656,140 4,592,556 SH   SOLE   4,592,556 0 0
OUTSET MED INC COM NEW 690145206   9,216,662 833,333 SH   SOLE   833,333 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   37,146,456 980,894 SH   SOLE   980,894 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   52,773,866 1,091,271 SH   SOLE   1,091,271 0 0
RAPT THERAPEUTICS INC COM 75382E109   5,391,115 4,418,947 SH   SOLE   4,418,947 0 0
REPLIGEN CORP COM 759916109   16,515,879 129,801 SH   SOLE   129,801 0 0
REVOLUTION MEDICINES INC *W EXP 12/17/202 76155X118   9,500 250,000 SH   SOLE   250,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   134,991,132 2,548,445 SH   SOLE   2,548,445 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   938,642 140,726 SH   SOLE   140,726 0 0
SCPHARMACEUTICALS INC COM 810648105   1,315,000 500,000 SH   SOLE   500,000 0 0
SIONNA THERAPEUTICS INC COM 829401108   13,086,516 1,251,101 SH   SOLE   1,251,101 0 0
SOLENO THERAPEUTICS INC COM 834203309   107,646,713 1,506,602 SH   SOLE   1,506,602 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   44,054,590 11,906,646 SH   SOLE   11,906,646 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   37,324,644 2,313,272 SH   SOLE   2,313,272 0 0
SURROZEN INC *W EXP 08/01/203 86889P117   5,000 166,666 SH   SOLE   166,666 0 0
TRAWS PHARMA INC COM NEW 68232V884   970,096 421,781 SH   SOLE   421,781 0 0
VAXCYTE INC COM 92243G108   26,679,970 706,567 SH   SOLE   706,567 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   416,706,457 6,563,340 SH   SOLE   6,563,340 0 0
VIKING THERAPEUTICS INC COM 92686J106   12,292,471 509,005 SH   SOLE   509,005 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   8,892,244 659,662 SH   SOLE   659,662 0 0
XENON PHARMACEUTICALS INC COM 98420N105   10,914,620 325,324 SH   SOLE   325,324 0 0
ZYMEWORKS INC COM 98985Y108   22,208,244 1,864,672 SH   SOLE   1,864,672 0 0