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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIVAX SA SPONSORED ADS 00370M103   36,621,233 328,884 SH   SOLE   328,884 0 0
ADAGIO MED HLDGS INC COM 00534B100   11,012,382 9,876,576 SH   SOLE   9,876,576 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109   2,116,700 152,500 SH   SOLE   152,500 0 0
ADMA BIOLOGICS INC COM 000899104   4,209,769 467,233 SH   SOLE   467,233 0 0
AGOMAB THERAPEUTICS NV SPONSORED ADS 00860C102   6,294,000 600,000 SH   SOLE   600,000 0 0
ALTO NEUROSCIENCE INC COM SHS 02157Q109   45,182,395 2,009,893 SH   SOLE   2,009,893 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   115,159,860 8,284,882 SH   SOLE   8,284,882 0 0
ANTERIS TECHNOLOGIES GLOBAL COM 03675P102   19,011,392 3,425,476 SH   SOLE   3,425,476 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   3,256,860 80,956 SH   SOLE   80,956 0 0
APOGEE THERAPEUTICS INC COM 03770N101   129,654,121 1,540,384 SH   SOLE   1,540,384 0 0
ARTIVION INC COM 228903100   59,957,560 1,637,290 SH   SOLE   1,637,290 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   350,281,925 1,531,421 SH   SOLE   1,531,421 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306   2,085,228 139,667 SH   SOLE   139,667 0 0
AXOGEN INC COM 05463X106   23,101,947 697,312 SH   SOLE   697,312 0 0
AXSOME THERAPEUTICS INC. COM 05464T104   25,344,549 149,950 SH   SOLE   149,950 0 0
BELITE BIO INC SPONSORED ADS 07782B104   24,231,532 151,979 SH   SOLE   151,979 0 0
BETA BIONICS INC COM 08659B102   8,446,299 842,944 SH   SOLE   842,944 0 0
BILLIONTOONE INC CL A 090168105   7,247,639 91,812 SH   SOLE   91,812 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   70,771,994 7,434,033 SH   SOLE   7,434,033 0 0
BRIGHT MINDS BIOSCIENCES INC COM NEW 10919W405   27,549,386 377,544 SH   SOLE   377,544 0 0
CELCUITY INC COM 15102K100   356,938,608 3,127,200 SH   SOLE   3,127,200 0 0
CELCUITY INC NOTE 2.750% 8/0 15102KAA8   15,875,774 6,500,000 PRN   SOLE   6,500,000 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   208,883,627 5,258,903 SH   SOLE   5,258,903 0 0
COGENT BIOSCIENCES INC COM 19240Q201   4,660,446 121,082 SH   SOLE   121,082 0 0
CONNECT BIOPHARMA HLDGS LTD SHS G23549101   2,076,864 792,696 SH   SOLE   792,696 0 0
CONTINEUM THERAPEUTICS INC CL A 21217B100   16,398,032 1,255,592 SH   SOLE   1,255,592 0 0
CORCEPT THERAPEUTICS INC COM 218352102   2,015,500 50,000 SH   SOLE   50,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   33,538,412 2,292,441 SH   SOLE   2,292,441 0 0
CRESCENT BIOPHARMA INC. COM G2545C104   3,801,525 206,942 SH   SOLE   206,942 0 0
CUMBERLAND PHARMACEUTICALS I COM 230770109   640,179 196,978 SH   SOLE   196,978 0 0
CYTOMX THERAPEUTICS INC. COM 23284F105   47,464,473 10,098,824 SH   SOLE   10,098,824 0 0
DAMORA THERAPEUTICS INC COM NEW 36322Q206   31,675,700 1,223,000 SH   SOLE   1,223,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   37,644,331 1,755,799 SH   SOLE   1,755,799 0 0
DBV TECHNOLOGIES S A SPONSORED ADS 23306J309   20,146,128 964,391 SH   SOLE   964,391 0 0
DYNE THERAPEUTICS INC COM 26818M108   84,646,051 4,668,839 SH   SOLE   4,668,839 0 0
EDESA BIOTECH INC COM NEW 27966L306   2,945,740 563,239 SH   SOLE   563,239 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   139,355,181 4,423,974 SH   SOLE   4,423,974 0 0
ENGENE HOLDINGS INC COM 29286M105   39,685,316 5,827,506 SH   SOLE   5,827,506 0 0
ENSYSCE BIOSCIENCES INC COM NEW 293602504   46,670 86,666 SH   SOLE   86,666 0 0
EVOLUS INC COM 30052C107   5,289,003 1,286,862 SH   SOLE   1,286,862 0 0
EVOMMUNE INC COM SHS 30054Y107   10,307,567 448,350 SH   SOLE   448,350 0 0
EXAGEN INC COM 30068X103   344,679 114,893 SH   SOLE   114,893 0 0
GUARDANT HEALTH INC COM 40131M109   27,711,000 300,000 SH   SOLE   300,000 0 0
IMMATICS N.V SHS N44445109   102,173,207 10,383,456 SH   SOLE   10,383,456 0 0
IMMUNOVANT INC COM 45258J102   39,678,994 1,597,383 SH   SOLE   1,597,383 0 0
INHIBIKASE THERAPEUTICS INC COM NEW 45719W205   3,889,200 2,315,000 SH   SOLE   2,315,000 0 0
INHIBRX BIOSCIENCES INC COM 45720N103   96,993,192 1,442,707 SH   SOLE   1,442,707 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   39,377,305 85,419 SH   SOLE   85,419 0 0
INVIVYD INC COM 00534A102   27,117,094 20,859,303 SH   SOLE   20,859,303 0 0
IONIS PHARMACEUTICALS INC COM 462222100   37,845,360 504,000 SH   SOLE   504,000 0 0
IRHYTHM HOLDINGS INC COM 450056106   12,395,169 105,026 SH   SOLE   105,026 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   32,138,500 170,000 SH   SOLE   170,000 0 0
LEONABIO INC COM 04746L203   19,113,830 1,859,322 SH   SOLE   1,859,322 0 0
MEDLINE INC COM CL A 58507V107   1,246,000 28,000 SH   SOLE   28,000 0 0
MEIRAGTX HLDGS PLC COM G59665102   89,312,864 10,326,103 SH   SOLE   10,326,103 0 0
MODERNA INC COM 60770K107   50,800,000 1,000,000 SH Put SOLE   1,000,000 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108   48,865,538 12,594,211 SH   SOLE   12,594,211 0 0
NEUMORA THERAPEUTICS INC. COM 640979100   9,952,989 5,104,097 SH   SOLE   5,104,097 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   8,569,687 65,050 SH   SOLE   65,050 0 0
NURIX THERAPEUTICS INC COM 67080M103   57,518,594 3,710,877 SH   SOLE   3,710,877 0 0
NUVALENT INC COM 670703107   161,922,737 1,580,505 SH   SOLE   1,580,505 0 0
OCULAR THERAPEUTIX INC COM 67576A100   4,235,000 500,000 SH Call SOLE   500,000 0 0
OCULIS HOLDING AG ORDINARY SHARES H5870P102   13,130,860 493,827 SH   SOLE   493,827 0 0
OMADA HEALTH INC COM 68170A108   9,884,168 786,330 SH   SOLE   786,330 0 0
OPUS GENETICS INC COM 67577R102   8,353,081 1,835,842 SH   SOLE   1,835,842 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   21,411,101 5,037,906 SH   SOLE   5,037,906 0 0
ORUKA THERAPEUTICS INC COM 687604108   68,449,324 1,395,501 SH   SOLE   1,395,501 0 0
OUTSET MED INC COM NEW 690145206   3,199,998 833,333 SH   SOLE   833,333 0 0
PALATIN TECHNOLOGIES INC COM NEW 696077601   1,079,082 61,945 SH   SOLE   61,945 0 0
PALISADE BIO INC COM 696389402   15,624,261 8,928,149 SH   SOLE   8,928,149 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   10,276,750 925,000 SH   SOLE   925,000 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   655,974,329 2,035,986 SH   SOLE   2,035,986 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   129,734,647 1,230,879 SH   SOLE   1,230,879 0 0
RAPPORT THERAPEUTICS INC COM 75383L102   21,087,051 673,923 SH   SOLE   673,923 0 0
RELAY THERAPEUTICS INC COM 75943R102   97,023,853 9,751,141 SH   SOLE   9,751,141 0 0
REPLIGEN CORP COM 759916109   33,053,341 280,541 SH   SOLE   280,541 0 0
REVOLUTION MEDICINES INC COM 76155X100   25,148,850 258,600 SH   SOLE   258,600 0 0
REVOLUTION MEDICINES INC *W EXP 12/17/202 76155X118   447,500 250,000 SH   SOLE   250,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   206,448,951 2,373,795 SH   SOLE   2,373,795 0 0
ROIVANT SCIENCES LTD SHS G76279101   229,507,270 8,285,461 SH   SOLE   8,285,461 0 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202   24,633,576 6,431,743 SH   SOLE   6,431,743 0 0
SIONNA THERAPEUTICS INC COM 829401108   26,396,820 658,439 SH   SOLE   658,439 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   85,727,851 11,906,646 SH   SOLE   11,906,646 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   190,825,869 3,783,225 SH   SOLE   3,783,225 0 0
SURROZEN INC COM NEW 86889P208   6,682,218 229,393 SH   SOLE   229,393 0 0
SURROZEN INC *W EXP 08/01/203 86889P117   2,667 166,666 SH   SOLE   166,666 0 0
SUTRO BIOPHARMA INC COM SHS 869367201   17,818,297 715,307 SH   SOLE   715,307 0 0
TANGO THERAPEUTICS INC COM 87583X109   16,906,561 808,153 SH   SOLE   808,153 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605   23,150,034 1,447,782 SH   SOLE   1,447,782 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   123,075,190 4,142,551 SH   SOLE   4,142,551 0 0
TWIST BIOSCIENCE CORP COM 90184D100   7,128,000 150,000 SH   SOLE   150,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   22,901,415 1,170,829 SH   SOLE   1,170,829 0 0
X4 PHARMACEUTICALS INC COM NEW 98420X202   27,826,486 6,737,648 SH   SOLE   6,737,648 0 0
ZYMEWORKS INC COM 98985Y108   87,892,353 3,510,078 SH   SOLE   3,510,078 0 0